DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Cftr

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_006236159.1	Gene:	Cftr / 24255	RGDID:	2332	Length:	1530	Species:	Rattus norvegicus

Alignment Length:	1481	Identity:	421/1481 - (28%)
Similarity:	719/1481 - (48%)	Gaps:	243/1481 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKG 73
            :|.|.|..:|.|.|.:..|||.||.:..|:.:|:|:..:...|..|.::..:.|:.|.|
  Rat    58 SPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDREQA------ 116

  Fly    74 DSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIY-A 137
             |.:||.::..:.|.|.||.:..|:.:...|: |:|..|:||..:|:.: :..|....:..|| .
  Rat   117 -SKKKPQLIHALRRCFVWRFVFYGVLLYLGEV-TKAVQPVLLGRIIASY-DPDNTEERSIAIYLG 178

  Fly   138 VLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLN 202
            :.|....:...||.||.:.|:.|:.|:||:|:.|.||:|.|:||...|...:.||:::||||:||
  Rat   179 IGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLN 243

  Fly   203 RFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALR 267
            :||..|...||:|:.||::::....|::.:..::|.|:.:|::.:..|..|.::..|.|.:.|.:
  Rat   244 KFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAK 308

  Fly   268 TDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIF 332
            .::|:.:.:|:|..|..:|.|.||....|:|..:|..|:...|:...:|....|.....|...:|
  Rat   309 INERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGFFVVF 373

  Fly   333 VSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVI 397
            :|:|.:.:..| :...:.|...:|..:||.:|::.||:.:..:.:.|..:|:|.:|:..:|..|:
  Rat   374 LSVLPYTVING-IVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQEYKVL 437

  Fly   398 D--------MSERRDEKAEEE-QHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQH----- 448
            :        :.|......||. |.||::|:..:..                |.....|.|
  Rat   438 EYNLMFTGLVMENVTAFWEEGFQELLEKVQLNNDD----------------RKTSNGENHLSFSH 486

  Fly   449 -----DLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWL 508
                 :.||.|:|:::::|:::|:.|..|:||:||:..|||||....|.::.||:.|::||..|:
  Rat   487 LCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWI 551

  Fly   509 FNASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTIVGERGASLSGGQRARICLARAV 572
            ...::::||:||:..|:.||::|:|.|.|:.|: :....|.|::||.|.:|||||||||.|||||
  Rat   552 MPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAV 616

  Fly   573 YRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSAC 637
            |:.||:||||.|...:|......:|:.|:...:..:..||||.:::.|:.||.|:|:.:|.....
  Rat   617 YKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGSSYFY 681

  Fly   638 GTYEEMLKSGQDFAQLL-----------------VESTQNSGGGDEIITSPNLSRQS-------- 677
            ||:.|:.....||:..|                 :..|......|:..|:.|.::||
  Rat   682 GTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDASTTWNKAKQSFRQTGEFG 746

  Fly   678 -----SALSTKSS--------------NGSSSSLE----SMV------EKEKPK----------- 702
                 |.||:.||              .|.|..|:    |:|      |...|:
  Rat   747 EKRKNSILSSFSSVKKISIVQKTPLSIEGESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFP 811

  Fly   703 --------------PSAVSSQESRSGGQI-------------------GLSM------------- 721
                          ||:|||...|:...|                   .||.
  Rat   812 GRRRQSVLDLMTFTPSSVSSSLQRTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEE 876

  Fly   722 ---------------------YKKYFGAGCG---VLVFVVLIMLCIGTQILAS------------ 750
                                 |.:||....|   ||::.||:.|   .::.||
  Rat   877 DLKECFFDDMVKIPTVTTWNTYLRYFTLHRGLFAVLIWCVLVFL---VEVAASLFVLWLLKNNPV 938

  Fly   751 -GGD-----YFLSYWVKNTASSSTLDIYYFTAINVG----LVICALLRTLLFFNITMHSSTELHN 805
             ||:     ...||.|..|:||    .||...|.||    |:..:|.|.|...:..:.:|..||.
  Rat   939 NGGNNGTKIANTSYVVVITSSS----FYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHR 999

  Fly   806 TMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWY 870
            .|...:....:..|:...:|.|||||:.|:..:|:.:|..:.|.||:...:.|.|.|:....|:.
  Rat  1000 KMLHSILHAPMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYI 1064

  Fly   871 LINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDN 935
            .:.|...:..|...|.::|.||:.:|:||:..|||:::|...:|.||.|:||...|......:..
  Rat  1065 FLATVPGLAVFILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHK 1129

  Fly   936 YQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQ 1000
            ..:||::.::.:::|.|.|...:|:..|.:.|.|...:..... ...|..|:.:|.|:.:...:|
  Rat  1130 ALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTG-EGEGTTGIILTLAMNIMSTLQ 1193

  Fly  1001 WGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQ-----PPK-------------SWPKEG 1047
            |.:..|.:.::.|.||.||.::.|:..|....:...|:     .|.             :||..|
  Rat  1194 WAVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGG 1258

  Fly  1048 KLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLSYNDGAILIDS 1112
            ::|.|||:::|..|.|:  :|:.:||:|.|.::||::||||:|||:|::|..|:....|.|.||.
  Rat  1259 EMVVKDLTVKYVDDGNA--ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDG 1321

  Fly  1113 LDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQ 1177
            :..|.:.|.:.|....:|.|:..:||||.|.||||..::.|:::||..:.|.||..|.:.|..|.
  Rat  1322 VSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLN 1386

  Fly  1178 SIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIA 1242
            ..:.:||...|.|.:||:||||::|.:.:|:::||.:||:||.|..:|:..:|..|..|||:...
  Rat  1387 FTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCE 1451

  Fly  1243 HRLNTIMDSDKVLVMDAGHVVEFGSPYELL-----------TASKAKVFHG 1282
            ||:..::|..:.||::.|:|.::.|...||           ::.|.|:|||
  Rat  1452 HRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRALSSSEKMKLFHG 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	416/1470 (28%)
		ABC_membrane	112..364	CDD:294371	75/252 (30%)
		ABCC_MRP_domain1	434..632	CDD:213217	78/208 (38%)
		ABC_membrane	736..955	CDD:294371	67/240 (28%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	84/220 (38%)
Cftr	XP_006236159.1	CFTR_protein	55..1518	CDD:273530	421/1481 (28%)
		ABC_membrane	139..357	CDD:294371	68/219 (31%)
		ABCC_CFTR1	444..724	CDD:213258	93/295 (32%)
		CFTR_R	693..898	CDD:291094	30/204 (15%)
		ABC_membrane	915..1196	CDD:279056	78/288 (27%)
		P-loop_NTPase	1258..1518	CDD:304359	92/247 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110