DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc4

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001028508.2	Gene:	Abcc4 / 239273	MGIID:	2443111	Length:	1325	Species:	Mus musculus

Alignment Length:	1332	Identity:	587/1332 - (44%)
Similarity:	838/1332 - (62%)	Gaps:	69/1332 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVAR 68
            :::.|||.:.|.:.|.:.|.:..|:...|.|:.|:..|::..|.|..:..||:|..:.|:.|:.|
Mouse     6 TEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLR 70

  Fly    69 CRRKGDSGRKPSVLRVIGRVFGWR--LIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHS- 130
            .::  || ||||:.:.|.:.: |:  ||:...|:  :|.|||...||.|..:|..|.::....|
Mouse    71 AKK--DS-RKPSLTKAIIKCY-WKSYLILGIFTL--IEEGTRVVQPLFLGKIIEYFEKYDPDDSV 129

  Fly   131 --YNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQV 193
              :.|..||.:|..|.|...:|.|.|...:....|::|||:...|||||||||.:::|.|||||:
Mouse   130 ALHTAYGYAAVLSMCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQI 194

  Fly   194 VNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTS 258
            |||||||:|:||:..|..||||.|||:.:..:..|:.:||::...|:::||:.||||:.:.::.|
Mouse   195 VNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLFS 259

  Fly   259 KLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFE 323
            .||.:||..||.|:|.|||:|:|:::||||.||:.|..||..:|:.|:|.|...:.|||:.::..
Mouse   260 SLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMASF 324

  Fly   324 ITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNF 388
            ....::.:||:...:||.|.|:||...|.....|..:|.||:.||||.:.:.:|.:||:|||.||
Mouse   325 FIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNF 389

  Fly   389 MMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLN 453
            ::            .||..:.:.|:..:          ||   .:|.::...|.|.:......|.
Mouse   390 LL------------LDELPQRKAHVPSD----------GK---AIVHVQDFTAFWDKALDSPTLQ 429

  Fly   454 NVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNIL 518
            .::...|.|:|:||:||||:|||||:.|:||||||.||.|.|.|:.:|.||:||:|:.:||.|||
Mouse   430 GLSFIARPGELLAVVGPVGAGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNIL 494

  Fly   519 FGLPMDKQRYRTVLKRCALERDLELLH-GDGTIVGERGASLSGGQRARICLARAVYRRADVYLLD 582
            ||...:|:||..|:|.|||::||:||. ||.|::|:|||:|||||:||:.||||||:.||:||||
Mouse   495 FGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLD 559

  Fly   583 DPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSG 647
            |||||||..||:|||..|:...|.:::.||||||||:|:.|..|:|:..|.:...|||.|.||||
Mouse   560 DPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSG 624

  Fly   648 QDFAQLLVESTQNSGGGDEIITSPNL----SRQSSALSTKSSNGSSSSLESMVE--KEKPKPSAV 706
            .||..||.:..:.:    |..|:|..    .|..|..|..|...|..||:....  ::.....||
Mouse   625 VDFGSLLKKENEEA----EPSTAPGTPTLRKRTFSEASIWSQQSSRPSLKDGAPEGQDAENTQAV 685

  Fly   707 SSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW------VKNTAS 765
            ..:||||.|:||...||.||.||......:.|::|.:..|:.....|::||:|      :.||.:
Mouse   686 QPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRN 750

  Fly   766 SS-----TLDIYYFTAINVGL----VICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHT 821
            ::     |||:.::..|..||    |:..:.|:||.|.|.:::|..|||.||:.:.:..:.||..
Mouse   751 ANGNITETLDLSWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFFDR 815

  Fly   822 NPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRD 886
            ||.|||||||:.|:|.:|:::|...||.||..|.:..:|.|.....||.||....:.:.|...|.
Mouse   816 NPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRR 880

  Fly   887 FYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTS 951
            ::|:|||||||||:..|||::||.|::|.||.||||..|::.....:|.:|||||..::.|::||
Mouse   881 YFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTS 945

  Fly   952 RAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSV 1016
            |.|...||..|..:||.|...:.......||||:|||::.||.:.||.||.:|||||:||.|.||
Mouse   946 RWFAVRLDAICAIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISV 1010

  Fly  1017 ERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKV 1081
            |||:||.||:.|..:.  .:|:||..||.||.:|..:::..|..|  .|.|||.|:..|:..|||
Mouse  1011 ERVIEYTDLEKEAPWE--CKKRPPPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTALIKSREKV 1071

  Fly  1082 GIVGRTGAGKSSLINALFRLSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLD 1146
            ||||||||||||||:||||||..:|.|.||.:.|.:|||||||.|:||||||||||:||||.|||
Mouse  1072 GIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD 1136

  Fly  1147 PFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMD 1211
            ||.::.|::||:|||:|.|||.|.:||..:.:.::|.|:|||||||||||||||||:.||||::|
Mouse  1137 PFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIID 1201

  Fly  1212 EATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASK 1276
            ||||||||:||.|||..||.||..|||||||||||||:||||::|:|:|.:.|:..||.|| .:.
Mouse  1202 EATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL-QNP 1265

  Fly  1277 AKVFHGMVMQTGKASFDHLLKVAENT--KQNH 1306
            ..:|:.||.|.||.....|.:.|:..  ::|:
Mouse  1266 ESLFYKMVQQLGKGEAAALTETAKQVYFRRNY 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	577/1295 (45%)
		ABC_membrane	112..364	CDD:294371	103/254 (41%)
		ABCC_MRP_domain1	434..632	CDD:213217	107/198 (54%)
		ABC_membrane	736..955	CDD:294371	89/233 (38%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	140/220 (64%)
Abcc4	NP_001028508.2	PLN03130	12..1284	CDD:215595	582/1311 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..690		7/32 (22%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:O15439	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2403
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I229
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm42331
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.970