DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc10

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001334325.1	Gene:	Abcc10 / 224814	MGIID:	2386976	Length:	1526	Species:	Mus musculus

Alignment Length:	1353	Identity:	438/1353 - (32%)
Similarity:	673/1353 - (49%)	Gaps:	172/1353 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSSLMFCFALPILFKG-RKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKGDSGRKPS 80
            ||...:.:..|:|.:| |.:..||.|..:.......|.|...|...|::..             .
Mouse   222 LSRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPAFLARVFQAHWKEGA-------------Q 273

  Fly    81 VLRVIGRVFGWRLIMSG-ITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIYAVLLIACI 144
            :.|.:.|.||...:..| :.:....||...  ||||:.|:. |.|.|.....:..:|.:.|....
Mouse   274 LWRALYRAFGCCYLALGLLKMVGTMLGFSG--PLLLSLLVG-FLEEGQEPLSHGLLYVLGLAGGT 335

  Fly   145 LASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLI 209
            :.|.:|.:.|...:..:.::.||||.|.:|||||:|..:.   ..||:|:|||..|..|......
Mouse   336 VISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSR---PPTGEVLNLLGTDSERLLNFAG 397

  Fly   210 HFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRM 274
            .||..|..||:|.|..|.||:|:|||...|:.:.:|.:|:...::........:.....|.||::
Mouse   398 SFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHKDARVKL 462

  Fly   275 MNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFV 339
            |.|::|||:|||.:.||:..|..:...|..|:..:|.:..|....:.....|..:......:.:|
Mouse   463 MTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICITIFITYV 527

  Fly   340 LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRD 404
            |.|.:|||.:.|...|...:|...::. ||..::...|..||:.||..|        :|:.....
Mouse   528 LMGHQLTATKVFTALALVRMLILPLNN-FPWVINGLLESKVSLDRIQRF--------LDLPSYSP 583

  Fly   405 EKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARW---GQEQHDLVLNNVNMSLRRGQLVA 466
            |              ..|......||.|.:|:......|   |..|...:   .::.:::|.||.
Mouse   584 E--------------AYYSPDPPAEPSTALELHEALFSWDPIGASQKTFI---SHLQVKKGMLVG 631

  Fly   467 VIGPVGSGKSSLIQAILGELPPESGSV---QVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRY 528
            ::|.||.|||||:.||.|||....|.|   ::|..:..|:||||:..|::|||||||...|.|.|
Mouse   632 IVGKVGCGKSSLLAAITGELHRLCGWVAVSELSKGFGLATQEPWIQCATIRDNILFGKTFDAQLY 696

  Fly   529 RTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHV 592
            |.||:.|||..||.:| .||.|.|||:|.:|||||||||.||||||:...:|||||||:|||..|
Mouse   697 REVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADV 761

  Fly   593 GRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVES 657
            ..||...|:.|.|.....:|.||:.::||.||::::|:.|.:...|...|:|.        ||::
Mouse   762 ANHLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEILP--------LVQA 818

  Fly   658 TQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEK----EKPKPSAVSSQESRSGGQIG 718
            .            |....:...::|...:.|...||...|:    |:.....:..:||:|.|.:.
Mouse   819 V------------PTAWAEKEQVATSGQSPSVCDLERTTEEELEVEQSTCGCLVQEESKSEGAVA 871

  Fly   719 LSMYKKYF---GAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVK------------------- 761
            |.:|:.|:   |:|....:.|.|:::    |...:|.|::|::|:.
Mouse   872 LHVYRAYWRAMGSGLAAAILVSLLLM----QATRNGADWWLAHWLSQLKAGRNGSREDPASCSPG 932

  Fly   762 ---------------------------NTASSSTLDIYYFTAINVGLV----ICALLRTLLFFNI 795
                                       ..||:.|.|::::..:...:.    :|.|||.:||...
Mouse   933 STALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNSLCTLLRAVLFAAG 997

  Fly   796 TMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGII 860
            .:.::..||:.:...|....:.|:.:.||||:||||::|:..||:.:|.::...:...:.|.|::
Mouse   998 ALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLL 1062

  Fly   861 CVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGA 925
            .||....||.|:....:...:|..:.:|..:.|:::||.::..||:|||.:.||.|||.:||.||
Mouse  1063 AVLGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGA 1127

  Fly   926 QQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYV-----ISVILHNFFNPPLHNAGQI 985
            ......:.....:|:....:...:|.:.....|.|...|.|     |:::.|   ...|.|.|.:
Mouse  1128 TYRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQH---QQGLANPGLV 1189

  Fly   986 GLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEK--QPPKSWPKEGK 1048
            ||.::.||.:||::...:....:.|..|.||||:.||....|:...:.|.:.  |...||..:|.
Mouse  1190 GLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEPHSQPLQSPHQQRISWLTQGS 1254

  Fly  1049 LVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR-LSYNDGAILIDS 1112
            :..:|:.|.|.|  ..|..|.|::|.::|.||:|||||||:|||||...||| |..|.|.:|:|:
Mouse  1255 VEFQDVVLVYRP--GLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDN 1317

  Fly  1113 LDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKE---------- 1167
            :||:.:.|.:|||::::|||||.|||||:|.||||...:.|..||:|||..||.|
Mouse  1318 VDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGESQA 1382

  Fly  1168 -EISE-------------LPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVD 1218
             :.|:             |..||...:.|.|.|.|:|||||:|||||:|.:.:||.:|||||:||
Mouse  1383 CQRSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVD 1447

  Fly  1219 PQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYEL 1271
            .:||.|:|.||..:|.:.||||||||||||::||:|||:.||.|||..||..|
Mouse  1448 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSAL 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	438/1353 (32%)
		ABC_membrane	112..364	CDD:294371	77/251 (31%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/204 (46%)
		ABC_membrane	736..955	CDD:294371	61/268 (23%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	119/245 (49%)
Abcc10	NP_001334325.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740