DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc9

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_035641.1	Gene:	Abcc9 / 20928	MGIID:	1352630	Length:	1546	Species:	Mus musculus

Alignment Length:	1288	Identity:	404/1288 - (31%)
Similarity:	667/1288 - (51%)	Gaps:	106/1288 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 RKPSVLRVIGRVFGWRLIMSGI--TIAALELGTRATVPLLLAGLISEFSEHGN------------ 127
            |.||:...:.|.||..:::|..  .:|.| ||...  ||.::|::...:|..|
Mouse   281 RTPSIWLAMYRAFGRPILLSSTFRYLADL-LGFAG--PLCISGIVQRVNEKTNTTREMFPETLSS 342

  Fly   128 -GHSYNAQIYAVLL-IACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT--SLGGT 188
             ....||.:.|||| :|.||....|...|.: .:...:.:|.|:.:.||.|.||||.:  |:|..
Mouse   343 KEFLENAHVLAVLLFLALILQRTFLQASYYV-TIETGINLRGALLAMIYNKILRLSTSNLSMGEM 406

  Fly   189 TTGQVVNLLSNDLNRFDRCLIHFHF----LWLGPLELLIASYFLYEQIGMASFYGISILVLYLPL 249
            |.||:.||::.:.|:    |:.|.|    ||..|:::::....||..:|.::..|.:::||..|:
Mouse   407 TLGQINNLVAIETNQ----LMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPI 467

  Fly   250 QTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNL 314
            |.:::...::.:..|...:.:|::..|||:.||:::|:|.||..|.|.:.:.|..|:||::...|
Mouse   468 QYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFAL 532

  Fly   315 LRGILLSFEITLGRIAIFVSLLGFV-LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFA-E 377
            ...:.:.....:...|:..:.:... ..|..|....||...:.::||  ....|..|.:.:|| :
Mouse   533 YTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL--VTPLFLLSTVVRFAVK 595

  Fly   378 LLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEP-----DTLVEIK 437
            .::|::::..|::.:|  :.:.|.|..|.....:...|....:|.|:. .|:|     |:..:.:
Mouse   596 AIISVQKLNEFLLSDE--IGEDSWRAGEGTLPFESCKKHTGVQSKPIN-RKQPGRYHLDSYEQAR 657

  Fly   438 ALRA---------------RWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELP 487
            .||.               .||...  ..|:|:::.:..|||..::|.||.|||||:.|||||:.
Mouse   658 RLRPAETEDIAIKVTNGYFSWGSGL--ATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 720

  Fly   488 PESGSV---------------QVSGKYS--YASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRC 535
            ...|.|               :...:||  ||:|:|||.||:|.:||.||.|.::|||:.|...|
Mouse   721 TLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSPFNRQRYKAVTDAC 785

  Fly   536 ALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDE 599
            :|:.|::|| .||.|.:||||.:||||||.|||:|||:|:..::..||||.||:|.|:..||..|
Mouse   786 SLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 850

  Fly   600 CMRGFL--GKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSG 662
            .:..||  .|:.|:||||:||:|..||.|:.|..|.|...||    ||..|.....|.|..:...
Mouse   851 GILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGT----LKDIQTKDVELYEHWKTLM 911

  Fly   663 GGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKK--- 724
            ...:.....::....:.|..|:...:..|.|:..:.|.........::........:.:..|
Mouse   912 NRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEEDNMSTVMRLRTKMPW 976

  Fly   725 -----YFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTA------SSSTLDIYYFTAI- 777
                 |..:|...|:|:::....:...::.: .||:|:.|....:      :..|..:..|:.:
Mouse   977 KTCWWYLTSGGFFLLFLMIFSKLLKHSVIVA-IDYWLATWTSEYSINHPGKADQTFYVAGFSILC 1040

  Fly   778 NVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVM 842
            ..|:.:| |:.:|....:.:.::..||:.:...:....:.||.|.|.|.|||||:.|...:|:.:
Mouse  1041 GAGIFLC-LVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHI 1104

  Fly   843 PAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMY 907
            |..:....:..|.....|.::....|.:|:....:.:|||:.:.::...|:|::.|:...:.|:.
Mouse  1105 PPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLL 1169

  Fly   908 SHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILH 972
            .|||.|..||.||||...:.....:.....|.::..|....:.:|......|......|::..:.
Mouse  1170 CHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIA 1234

  Fly   973 NFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEK 1037
            :....  .|:|.:||.:..||.:|..:.|.:|..|:||..|.:|::|..:..::.|....:....
Mouse  1235 SISGS--SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPS 1297

  Fly  1038 QPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL- 1101
            |.|:.||:||::...||.:|||  .|...|||.:...|:|.:||||.||||:|||||..|.||:
Mouse  1298 QVPEHWPQEGEIKIHDLCVRYE--NNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMV 1360

  Fly  1102 SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLK 1166
            ...||.|:||.:|.:.:.||.|||::|||.|:|:||||::|:||||..:..||:||:|||...||
Mouse  1361 DIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLK 1425

  Fly  1167 EEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRN 1231
            ..:..||.||.:.::|||.|||||||||.|||||.:|::.||:||||||::|..|:.::|..:..
Mouse  1426 NMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1490

  Fly  1232 KFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMV 1284
            .|.|.||:|||||::||:.:|.|:||..|:::|:.:| |.|.|.:..||...|
Mouse  1491 AFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTP-ESLLAQEDGVFASFV 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	399/1275 (31%)
		ABC_membrane	112..364	CDD:294371	72/272 (26%)
		ABCC_MRP_domain1	434..632	CDD:213217	95/232 (41%)
		ABC_membrane	736..955	CDD:294371	49/225 (22%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	112/221 (51%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	404/1288 (31%)
Abcc9	NP_035641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		2/22 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.800