Protein Alignment CG31793 and Abcc8

DIOPT Version :9

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: XP_036008753.1
• Gene: Abcc8 / 20927
• MGIID: 1352629
• Length: 1597
• Species: Mus musculus
• Alignment Length: 1476
• Identity: 438/1476 - (29%)
• Similarity: 712/1476 - (48%)
• Gaps: 297/1476 - (20%)

  Fly    28 ILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKG----------DSGRKPSVL 82
            |.||..::...|.||         ..||..|.|.:.:.::    ||          .:.|||..|
Mouse   196 IFFKTPREVKPPEDL---------QDLGVRFLQPFVNLLS----KGTYWWMNAFIKTAHRKPIDL 247

  Fly    83 RVIGRV-----------------------------------------FGWRLIMSG-ITIAALEL 105
            |.||::                                         ||.||::|. ..|.|..|
Mouse   248 RAIGKLPIAMRALTNYQRLCAAFDAQARKDTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLL 312

  Fly   106 GTRATVPLLLAGLISEFSEHGNGHSY-------------------NAQIYAVLL-IACILASVLL 150
            |...  ||.:.|::....:  ..|.:                   ||.:.|||| :|.:|....|
Mouse   313 GFAG--PLCIFGIVDHLGK--ENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFL 373

  Fly   151 THPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT--SLGGTTTGQVVNLLSNDLNRFDRCLIHFHF 213
            ...|.:. :...:.:|.|:.:.||.|.:.||.:  |:|..|.||:.||::.|.|:    |:.|.|
Mouse   374 QASYYVA-IETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQ----LMWFFF 433

  Fly   214 ----LWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRM 274
                ||..|:::::....||..:|:::..|.::::|..|:|.:::...|:.:..|...:::|::.
Mouse   434 LCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQ 498

  Fly   275 MNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFV 339
            .||::.||:::|:|.||..|...:...||.||:|:|...:...|.:.....:...|:.::.:|.|
Mouse   499 TNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHV 563

  Fly   340 --LGGGELTAERAFCVTAFYNILRRTVSKFF--PSGMSQFAELLVSMRRITNFM----MREE--- 393
              ....:.:...||...:.::||   |:..|  .|.:....:.|||:::::.|:    :|||
Mouse   564 SFFKESDFSPSVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCA 625

  Fly   394 --------------ANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWG 444
                          |..:.:..|:....||.:.||..:: |..|...|...:..|:|......|.
Mouse   626 PREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQ-RLTPSMDGDADNFCVQIIGGFFTWT 689

  Fly   445 QEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSV---------------- 493
            .:... .|:|:.:.:.||||..::|.||.|||||:.|.|||:...||:|
Mouse   690 PDGIP-TLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRY 753

  Fly   494 -----------------QVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDL 541
                             :..|..:||||:|||.||:|.:||.|..|.:||||:.|::.|:|:.|:
Mouse   754 CLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDI 818

  Fly   542 ELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFD----ECM 601
            ::| |||.|.:||||.:||||||.||.:|||:|:..:|..||||.||:|.|:..||..    |.:
Mouse   819 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELL 883

  Fly   602 RGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGGDE 666
            |.  .|:.|:||||:||:|..||.|:.|..|.:...||.::..:|.   .||...
Mouse   884 RD--DKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE---CQLFEH---------- 933

  Fly   667 IITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPS-----AVSSQ---------------ES 711
              ....::||...|..          |:::|::.|:||     |:||:               ||
Mouse   934 --WKTLMNRQDQELEK----------ETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAES 986

  Fly   712 RSGGQIGLSMYK----------KYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW------- 759
            .....:...:::          ||. :..|||:..:|:...:...::....||:|:.|
Mouse   987 EEDDNLSSVLHQRAKIPWRACTKYL-SSAGVLLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVL 1050

  Fly   760 ---VKNTASSS--TLD--IY--YFTAI-NVGLVICALLRTLLFFNIT-----MHSSTELHNTMFQ 809
               .:|.:.|.  .||  :|  .||.: ::|:.:|      |..::|     :..:..||.::..
Mouse  1051 SPAARNCSLSQECALDQSVYAMVFTVLCSLGIALC------LVTSVTVEWTGLKVAKRLHRSLLN 1109

  Fly   810 GLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVT-----NPW 869
            .:....:.||.|.|.|.|||||::|...:|:.:|:. |:|    |:.:.::||..:|     .|.
Mouse  1110 RIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-LEC----LSRSTLLCVSALTVISYVTPV 1169

  Fly   870 YLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAM----GAQQTLI 930
            :|:....:.:..|:.:.::...|||:::|:...:.|:.|||:.|:.||.||||.    ..||.|:
Mouse  1170 FLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLL 1234

  Fly   931 GQYDNYQDLHSSGYYTFVSTSR----------------AFGYYLDLFCVAYVISVILHNFFNPPL 979
                .|.|.::.......:.:|                ..|..:.|...|..||..||...
Mouse  1235 ----EYTDSNNIASLFLTAANRWLEVRMPGPAAVLPQEYIGACVVLIAAATSISNSLHREL---- 1291

  Fly   980 HNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWP 1044
             :||.:||.:|.||.::..:.|.:|..|::|..:.:|:|:......:.|......|....||:||
Mouse  1292 -SAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWP 1355

  Fly  1045 KEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAI 1108
            .:||:..::||:||  |::...|||.::..|.|.:|:||.||||:||||...|.||: ...:|.|
Mouse  1356 DQGKIQIQNLSVRY--DSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRI 1418

  Fly  1109 LIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELP 1173
            :||.:|...:.||.|||::|||.|:|||||||:|:||||.::..|..||:|||...||..:..||
Mouse  1419 IIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALP 1483

  Fly  1174 SGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTV 1238
            .||.:||:|||.|||.|||||.|||||.:|:..|.:||||||::|..|:.::|..:...|.|.||
Mouse  1484 GGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTV 1548

  Fly  1239 LTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMV 1284
            :|||||::||:.:|.|:|:..|.::||..|.:|| :.|..||...|
Mouse  1549 VTIAHRVHTILSADLVMVLKRGAILEFDKPEKLL-SQKDSVFASFV 1593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	433/1463 (30%)
		ABC_membrane	112..364	CDD:294371	69/279 (25%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/235 (40%)
		ABC_membrane	736..955	CDD:294371	61/265 (23%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	110/221 (50%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	428/1439 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810