DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and haf-7

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_506645.1	Gene:	haf-7 / 190115	WormBaseID:	WBGene00001817	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	841	Identity:	189/841 - (22%)
Similarity:	347/841 - (41%)	Gaps:	174/841 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 WLFNAS-------VRDNILFGLPMDKQRYRTVLKRCALERDLELLHGDGTIVGERGASLSGGQRA 564
            |:||..       :.|......|:|      .:..| |.|.:.||  ...|:..||.
Worm    32 WVFNLDDVFKTFHINDYNYMISPLD------FVGLC-LFRQVSLL--VALIIVRRGK-------- 79

  Fly   565 RICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLV-------ILVTHQLQFLED 622
                |..:.:...:|.|...|..:...|...:||| ..|||....|       :.:|..|.|...
Worm    80 ----AERLKKYMTIYDLFGILGYMIAVVKLLVFDE-TSGFLKSPGVFMSVGSAVFLTFSLPFAIR 139

  Fly   623 ADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNG 687
            ..|:     |.......||.:.::.:..|...||:...|..|.....:|..:..|::.|: |::.
Worm   140 KTLL-----GKKKEGAEYERLTENTETAANTNVENGTASTNGTASTATPTAATSSTSRSS-STDE 198

  Fly   688 SSSSLESMVEKEKPKPSAVSSQESRSGGQIGL-SMYKKYFGAGCGVLVFVVLIMLCIGTQILASG 751
            ..:...|..||||..|......:.     :.| |:..|:|.|.. ||:||..|:..|...:.:.
Worm   199 EDNDAVSKEEKEKRLPLLTHLWQI-----VKLCSVQWKWFSAAY-VLLFVDCILNLIEPALYSQ- 256

  Fly   752 GDYFLSYWVKNTASSSTLDIYYFTAINVGLVICALLRTLLFFNITMH-------------SSTEL 803
                        ..|:.:.:..|..:...   |.:|..:.|...|::             ::..:
Worm   257 ------------MMSTAIRMKSFDVLKRA---CIVLAAVQFTEATVNTVRYICMQYAERLTARNI 306

  Fly   804 HNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNP 868
            ..::|:.:....:.||..|.:|::::|...|...:...:|        :::..|       |.|.
Worm   307 RVSLFRAILHQDISFFDDNKTGQLMSRITKDSESISNSLP--------VYIETT-------VNNS 356

  Fly   869 WYLINTFAMMLAFYY-WR----------------DFY----LKTSRDVKRLEAVARSPMYSHFSA 912
            :.|..:..:|  ||| |:                .||    .|.|.......||:...:....||
Worm   357 FMLFGSAPIM--FYYSWQLAISTFVTFPIILLTTKFYGLIVEKLSEKENDATAVSNETVEEVLSA 419

  Fly   913 TLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLF---------CVAYVI- 967
                :.|:|:..|::....:|....|    .::...:.:..||.:.:.|         .:.|:.
Worm   420 ----IRTVRSFAAEKIENMRYTRDTD----AWFKISTKTVVFGTFFNYFWATMWNIEDVIIYLYG 476

  Fly   968 ------------SVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVL 1020
                        :::.:.|::..||:|    |....:|            .:::...:.|..:|:
Worm   477 GYLTLNGRMEPDALLTYIFYHWRLHSA----LNAFSSL------------FSDVMKTIGSSRKVI 525

  Fly  1021 EYKDLDPEGDFNSPAEKQPPKSWPK-EGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIV 1084
            ...:..||.|:....|.      |: .|.::.:|:...| |...:..||..::.:|.|.:.:.:|
Worm   526 HIMNRQPELDYEFGTET------PEIVGNIIFEDVEFAY-PTRKNANVLNKINLSIDPGKTIALV 583

  Fly  1085 GRTGAGKSSLINALFRLSY--NDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYN-LD 1146
            |.:|.|||:|: :|.:..|  ..|.||||.....:|......:.|:::.|||.|||||:|.| |.
Worm   584 GPSGNGKSTLV-SLIQQFYTPQSGRILIDGTPIQNIDHLHYHTNIALVAQEPTLFSGTVRENILY 647

  Fly  1147 PFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMD 1211
            ..|...|:.:.:..|..::.|.:|::..|..:...|.|...|.||:|.:.:|||::|:.|:|::|
Worm   648 GLENGTDEDMMRVAEMANVHEFVSKMEKGYDTKCGEKGVQMSGGQKQRIAIARALIRDPRVLILD 712

  Fly  1212 EATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELL 1272
            |||:.:|.:::|::|..:....::.|||.|||||:|:..:|::.|::.|:|.|.|:..||:
Worm   713 EATSALDSESEAMVQEALNRCARERTVLVIAHRLSTVRSADRIAVIEKGNVTEMGNHEELM 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	189/841 (22%)
		ABC_membrane	112..364	CDD:294371
		ABCC_MRP_domain1	434..632	CDD:213217	30/138 (22%)
		ABC_membrane	736..955	CDD:294371	39/252 (15%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	75/223 (34%)
haf-7	NP_506645.1	3a01208	17..784	CDD:273363	189/841 (22%)
		ABC_membrane	238..494	CDD:279056	46/296 (16%)
		ABC_MTABC3_MDL1_MDL2	549..787	CDD:213216	76/227 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000