DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and pgp-7

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001361833.1	Gene:	pgp-7 / 188697	WormBaseID:	WBGene00004001	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1143	Identity:	267/1143 - (23%)
Similarity:	472/1143 - (41%)	Gaps:	195/1143 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 YNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYR-------KALRLSRTSLGGT 188
            |...:|.|:|...:......|   ...:.|..||  ....:..||       :.||.........
Worm    95 YERGMYQVVLYFFLCGCAYFT---FASIQHAIMK--YVGDNTTYRVRKQYISRLLRKDAEYFDNV 154

  Fly   189 TTGQVVNLLSNDLNRF-----DRCLIHFHFL--------------WLGPLELLIASYFLYEQIGM 234
            :||.:..:|:::|.||     ::..:.|..|              |      .:|||.::..:|:
Worm   155 STGHLSTVLNDNLERFREVFNEKIALIFALLTDFVVGTALAFYTDW------RLASYGIFFSLGI 213

  Fly   235 ASFYGI----SILVLYLPLQTYLSRVTSKLRLQT--ALRTDQRVRMMNEIISGIQVIKMYTWERP 293
            | |.|.    .::.......|:.:...| :..||  |.:|...:...|      ..|:.||.|..
Worm   214 A-FSGFINSAGVMKTTGKQNTHYANAGS-IAFQTLGAYKTVCSLNGQN------TEIERYTEELK 270

  Fly   294 FGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYN 358
            .|:..| :.|:.|.||.     ||....|..:|..:.::|. ...:..|   :.|.|..|..|:.
Worm   271 AGEKYG-IHRALMYSIS-----RGFTYFFCNSLNTVILYVG-ANMIYSG---SLEPAVVVRIFHY 325

  Fly   359 IL--RRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSER-RDEKAEEEQHLLKEVEKR 420
            ::  ...:|:..|. :|:.|..:.|...|...:::|: |||:..|. .|.:.|...::..:..|.
Worm   326 MMFGAFCLSEALPH-ISRLAGAISSTAPIAEMLIKED-NVIEKDETDYDVEVEVNGNISFKNVKF 388

  Fly   421 SYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGE 485
            |||.    .||.                 .||..::..::.|:.:|::|..|||||:::|.:|..
Worm   389 SYPT----RPDA-----------------QVLKGISFDVQNGECIALVGASGSGKSTVVQLLLHY 432

  Fly   486 LPPESGSVQVSGK-------------YSYASQEPWLFNASVRDNILFGLPMDK--QRYRTVLKRC 535
            ...:||::.:.|.             ....||||.|||.::.:||.||.|...  :.|..:.|..
Worm   433 YNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYGALRKAN 497

  Fly   536 ALERDLELLHGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDT---HVGRHLF 597
            |.:.......|..|||||||..|||||:.||.:||.:.|...:.|||:..||:|.   .|.:...
Worm   498 AYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQVVQKAL 562

  Fly   598 DECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEML-KSG--QDFAQL-LVEST 658
            :...:|    :..|:|.|:|..:.:|..|::|.||.:...|.::|:: |.|  .|..|. |:||.
Worm   563 ENASQG----RTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQLLESH 623

  Fly   659 QNSGGGDEI--ITSPNLSRQSSALSTKSSNGSSSS--------LESMVE---KEKPKPSAVSS-- 708
            .:.   :|:  :.:..||::.|.|.:.:...|:|:        :|.:::   ||..|.|.:..
Worm   624 DDH---EELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGAKKSNLREIV 685

  Fly   709 QESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQ--ILASGGD--YFLSYWVKNTASSSTL 769
            ::.|..   ...::...||:....:.:.:|..|.:.|.  ....|.|  |:...|..:
Worm   686 KQCRPD---YCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLWALS------- 740

  Fly   770 DIYYFTAINVGLVI-CALLRTLLFFNITMHSSTELHNTMFQG-LSRTALYFFHTNPSG-RILNRF 831
              :.|.|:...|.: |   :...|..::...||.|....|.. ||....::...|.|. |:.||.
Worm   741 --FMFLAVFRPLTLYC---QYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNRL 800

  Fly   832 ANDLGQ----VDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTS 892
            ..|...    ||:.:..|::..:.|.:.:| ...:.|......::..|.::....|..|...:||
Worm   801 NTDSSNVKAAVDDRLGCVIMTVVAISIAIT-TASLYCWKMTLEVLIFFPLLYLAEYCYDAATETS 864

  Fly   893 --RDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQY-DNYQDLHSSGYYTFVSTSRAF 954
              .|....|...|:.:     ..|..:.|:||:..:..::... ::.|.:|.|.:...:....|.
Worm   865 IQEDTIAFENSNRTAI-----EALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAAN 924

  Fly   955 GYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSA-----ELENAMT 1014
            |..|..:...|.:|.....:.......|......|.:.|.||.    .|..||     :.:.|:.
Worm   925 GLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTA----NMAGSAAAYLPDYKKAVH 985

  Fly  1015 SVERVLEYKDLDPEGDFNSPA----EKQPPKSWPKEGKLVTKDLSLRYE--PDTNSPCVLKGLSF 1073
            :...:...        |..||    .....|...::|:::.:::...|:  ||.   .:|.|::.
Worm   986 AAGLIFHL--------FTYPATMPFSSSDGKKNIEKGEIIGENVQFHYDQRPDR---MILNGVNL 1039

  Fly  1074 TIQPMEKVGIVGRTGAGKSSLINALFRLSYN-DGAILIDSLDTNDIGLHDLRSKISIIPQEPVLF 1137
            .:.|.:.:.:||.:|.|||::|:.|.|..:. ||.:.|||.:..||.|:.|||.::::.|||.||
Worm  1040 KVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLF 1104

  Fly  1138 SGTMRYNL--DPFEQYPDDKLWKALEDVHLKEEISELP 1173
            :.::|.||  ......|..:|.|||:..:....:.:.|
Worm  1105 NCSIRENLLYGLTRSVPQLELEKALQTANAFNFVFQFP 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	267/1143 (23%)
		ABC_membrane	112..364	CDD:294371	55/266 (21%)
		ABCC_MRP_domain1	434..632	CDD:213217	63/215 (29%)
		ABC_membrane	736..955	CDD:294371	46/232 (20%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	41/132 (31%)
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	146/581 (25%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	77/261 (30%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	62/340 (18%)
		TM helix 1	695..718	CDD:350022	4/22 (18%)
		TM helix 2	733..781	CDD:350022	11/59 (19%)
		TM helix 3	790..835	CDD:350022	11/45 (24%)
		TM helix 4	836..885	CDD:350022	10/53 (19%)
		TM helix 5	897..947	CDD:350022	8/49 (16%)
		TM helix 6	956..989	CDD:350022	8/36 (22%)
		P-loop_NTPase	1019..>1143	CDD:393306	40/127 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000