Protein Alignment CG31793 and pgp-11

DIOPT Version :9

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_001364583.1
• Gene: pgp-11 / 183971
• WormBaseID: WBGene00004005
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 1303
• Identity: 297/1303 - (22%)
• Similarity: 535/1303 - (41%)
• Gaps: 258/1303 - (19%)

  Fly   100 IAALELGTRATVPLLLAGLISE-FSEHGNGHSYNAQIYAVL-------------LIACILASVLL 150
            |.||..||...|.||:.|.|:: :..:||....:..:|:||             |:..::..|.:
 Worm    51 ICALLGGTIQPVVLLIGGWITDLYLTNGNTAGNDEFLYSVLTLIYAGLGFGVIILVLALIQGVCI 115

  Fly   151 THPYMMGMMHLAMKMRVAVSSAIYRK-ALRLSRTSLGGTT--TGQVVNLLSNDLNRFDRC--LIH 210
                ..|...:...:|.....|:.|: |..|.:.|.|..|  ..:.:.::|:.|.  ::|  |:.
 Worm   116 ----QRGTSRILDSIRKEFLGAVLRQDANWLDKHSSGSITCQLNENIEVISDGLG--NKCCMLVR 174

  Fly   211 FHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTA---------- 265
            ...::...   :||..|:..|:...:|....:....|.|.|.::.|:::..:..:
 Worm   175 GFAMFTSS---IIACAFINWQLTFITFTMGPVSAFVLHLLTKVNEVSNEELMSLSAQSHAIIEES 236

  Fly   266 ---LRTDQRVRMMNEIISGI-----QVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSF 322
               :||.|.....|.:|:.:     ::.|.|.....:......:....:..|..::|..|..|.|
 Worm   237 ILNVRTVQSCNGQNFMITKLNQVNEKIKKFYNKSTFWAGFFDGLALFVIYFITGISLFFGCRLYF 301

  Fly   323 EITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFP--SGMSQFAELLVSMRRI 385
            ...:|:            .|..:......|||.::      :....|  |.:.|.|
 Worm   302 NQEIGK------------AGDVILIVNTICVTGYF------LGLLGPHMSSLQQAA--------- 339

  Fly   386 TNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDL 450
            |:|::                      |.|.:|  |.|...|||.    |||....|...|..|:
 Worm   340 TSFLL----------------------LYKTIE--SAPKSEGKEG----EIKISSTRGNIEFRDV 376

  Fly   451 ----------VLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGK------- 498
                      ||..:::.:..||.||::|..|.|||:.|..:........|.:.:.||
 Worm   377 RFKYFTRDNEVLQGLSLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEGEILIDGKNIDMLDA 441

  Fly   499 ------YSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGA 556
                  .....|||.||:.::.:||..|..:|::..:|..........:|.| :|..|.:|..|.
 Worm   442 KSLRQQIGIVQQEPKLFDGTIMENIKLGRNVDEETIKTAADIANASSFIEKLENGYETRLGPGGV 506

  Fly   557 SLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLE 621
            .|||||:.|||:|||:.....:.|||:..||:|:| ..|:.::.:......:..|::.|:|..|:
 Worm   507 QLSGGQKQRICIARALVTSPSILLLDEATSALDSH-NEHIVNKALTKASEGRTTIIIAHRLSSLK 570

  Fly   622 DADLIVIMDKGHVSACGTYEEMLKSGQDFAQL-----LVESTQNSGGGDEIITSPNLSRQSSALS 681
            ..|.|.::|:|.....||::|::..|..:|:|     :.:|::.....:|:..:..:.::...:.
 Worm   571 SVDRIYVLDQGKTKEIGTHDELILLGGIYARLAKSQEVEQSSKKDWEREELRRAEKMKKKGRTVE 635

  Fly   682 TKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIM------ 740
            ....|  |:.|:.  .:.....|.::..|.:.....|:|....|.......|:.::.::
 Worm   636 IIEPN--STILQE--HEHNFVGSVITENEEQKISFSGISKLFNYLPKHRKTLILIIALLIPRAIE 696

  Fly   741 LC---IGTQ-----ILASGGDYFLSYWVKNTASSSTLDIYYFTAINVGLV-ICALLRTLLFFNIT 796
            ||   ||..     :..|..||..  |...|.:..||....|..::..|: :|..|...:...:.
 Worm   697 LCSYGIGMSFAFKTLQRSKDDYMT--WNYITLAQQTLAGITFWILHTSLMYLCGWLANEVMNEVK 759

  Fly   797 MHSSTELHNTMFQGLSRTALYFFH--TNPS---GRILNRFANDLGQVDEVMPAVMLDCIQIFLTL 856
            ....:|:       |::...||.:  |:||   .||::...|
 Worm   760 QEMLSEV-------LNKPIPYFDNPETSPSACVSRIISHAHN----------------------- 794

  Fly   857 TGIICVLCVTN-----PWYLINT-FAMMLAF-YYWR-----------------DFYLKTSRDVKR 897
                |..|:.:     .|::..| |:::||| :.|.                 .|.....|....
 Worm   795 ----CYACLDHRAIRFVWFIAGTIFSLLLAFPFVWELGVLGLGITILLTIFSLHFVSVAHRAHSE 855

  Fly   898 LEAVARSPMYSHFSATLV-GLPTIRAMGAQQTLIGQYDNYQDLHSSGYYT----FVST------- 950
            ...:.:|   ..|:..:| .:..|:.:..:.....::..|  |.:|..|.    |||:
 Worm   856 KSVMDKS---GEFAVEIVEHIRAIKLLAVEGYFENKFSEY--LKTSEIYENKIGFVSSLNFAITQ 915

  Fly   951 SRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSA----ELEN 1011
            |..|...:.||.|..::  |.|..::|     .::.||...|    .|..||:...:    |:..
 Worm   916 SYVFACDMLLFFVGTLL--IYHGRYSP-----DKVFLAFNGA----QMSAWGVMYFSPWFPEIVR 969

  Fly  1012 AMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQ 1076
            ...|..::..:.|   :...||.:....|:.   .||:...|::..| |.|....|.:|.|..|.
 Worm   970 GSASANQIFSFFD---KNRTNSTSGLSKPEI---NGKVEVSDVTFAY-PSTPHRNVCEGFSLNIP 1027

  Fly  1077 PMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGT 1140
            ....:.:||.:|.|||::|:.|.|. |...|.|.:|..|.:.|.::.||:.||::.||||||:.|
 Worm  1028 KGHSIALVGASGCGKSTIISMLERFYSAKAGRISVDDNDIDGIDVNHLRNNISVVGQEPVLFNAT 1092

  Fly  1141 MRYNLD-PFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRE 1204
            :|.|:. ..::...:::.||.:..:....|...|.|..:|:.|||.:.|.||:|.:.:||||:|:
 Worm  1093 IRENITIGIDEVSVEEVQKACKAANAAGFIESFPLGYDTIVGEGGASLSGGQKQRIAIARAIIRK 1157

  Fly  1205 NRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPY 1269
            .:||::||||:.:|.|::.::|..:|:.....|.:.:||||:|:...|.:..:..|.|.|:|:..
 Worm  1158 PKILLLDEATSALDTQSEEIVQKALRSATTGRTSIIVAHRLSTVQHCDTIYYISRGAVAEYGTHA 1222

  Fly  1270 ELL 1272
            ||:
 Worm  1223 ELV 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	297/1303 (23%)
		ABC_membrane	112..364	CDD:294371	50/288 (17%)
		ABCC_MRP_domain1	434..632	CDD:213217	63/221 (29%)
		ABC_membrane	736..955	CDD:294371	48/274 (18%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	77/222 (35%)
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	297/1303 (23%)
		MdlB	46..607	CDD:224055	140/620 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000