DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and mrp-3

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1360	Identity:	444/1360 - (32%)
Similarity:	706/1360 - (51%)	Gaps:	142/1360 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRK-- 72
            |.|:|..:|..:..:...|:..|.::||...|:::..::.:...|...:...|..:..:.|.|
Worm   194 PEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWLKQTEKAREKQV 258

  Fly    73 ------------------------------GDSGR---KPSVLRVIGRVFGWRLIMSGITIAALE 104
                                          .|..|   :|||:..:.::..|. |:.|..|..|.
Worm   259 KLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWE-ILGGSFIKFLS 322

  Fly   105 LGTRATVPLLLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAV 169
            ...:...|..|..||. |.|..|....|....||.|........|..:.|.:.|..:..|::..:
Worm   323 DLLQFANPTFLNYLIL-FIETPNAPLINGIGLAVGLFLAGQIKSLFMNTYFIAMTRVGAKIQTML 386

  Fly   170 SSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGM 234
            |.|:|.|:|.||.|:....|.|::||:||.|::||..........|..|.:::|....|.:.||:
Worm   387 SCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLLSQTIGV 451

  Fly   235 ASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIG 299
            |.:.||.:::..:|:...:|.:|.:.:|:.....|:|:|::||:::||:|:|:..||....:.|.
Worm   452 AVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETAMEETIE 516

  Fly   300 QMRRSEMSSIRQMNLLRGILLSFEITLGRIA-IFVSLLGFVL-----GGGELTAERAFCVTAFYN 358
            ::|..|:..|:|..||:    :|...|...| :||:|..|.:     ....||...||...:.:|
Worm   517 RVRDKELKMIKQSALLK----TFADCLNVGAPVFVALSSFTVFVLIDPKNVLTPNIAFVSLSLFN 577

  Fly   359 ILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEAN--VIDMSERRDEKAEEEQHLLKEVEKRS 421
            :||..: ......::|..:|:||.:|:..|:..:|.:  .||                ||:....
Worm   578 LLRGPL-MMAAELVAQTVQLVVSNKRVRTFLCEKEVDTAAID----------------KEIRGEL 625

  Fly   422 YPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGEL 486
            |        ...|||.:....|...: ..:|:::.......:||.|:|.||||||||:.|.|||:
Worm   626 Y--------TNTVEIHSGSFAWDSAE-ARILSDIEFLAGSKELVTVVGSVGSGKSSLLLAALGEM 681

  Fly   487 PPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTI 550
            ....|.|.|.|..:|.||:||:.|.|::.|:|....::...|:.|::.|||:.|| :|..||.|.
Worm   682 EKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKEDLKQLPDGDDTE 746

  Fly   551 VGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILV 613
            :||:|.:|||||:|||.||||||:..|||.|||||||||.|||:|:||..:  .|.|.....|||
Worm   747 IGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPNGMLSHTTRILV 811

  Fly   614 THQLQFLEDADLIVIMDKGHVSACGTYEEML----------KSGQDFAQLLVESTQNSGGGD--- 665
            |:...||:::..|::|..|.:..||||.|:|          :...::||....|.:.|||.:
Worm   812 TNCTSFLQESGKIIVMKDGRIKHCGTYNELLTDVEAREYLQEVDNEYAQAQESSGEESGGEENSD 876

  Fly   666 ----EIITSPNLSRQS--SALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKK 724
                .|.:...:||.|  |.:|.|.|.      .|:|||:  ||.|:.::|..:.|::...:|..
Worm   877 ILPGSIASGSRMSRLSRLSKISRKKSK------SSIVEKK--KPDALITKEEAAIGRVNPGVYLL 933

  Fly   725 YFGAGCGVLVFVVLIMLCIGTQI-LASGGDYFLSYWVKNTASSSTLDIYYFTAINVGL------- 781
            ||.| .|::.:|:...:.:...: .|.|...:|:.|     |.:.:||.:...::||.
Worm   934 YFKA-MGIVTYVLPYAIAVVLNVSFALGRSLWLTAW-----SDANIDINHPDTMSVGARLGVYAG 992

  Fly   782 -----VICALLRTLLFFNITM------HSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDL 835
                 ||      .|||::.:      .:|..||..:...:.|..|.:|...|.|||:||.|.|:
Worm   993 FGITEVI------FLFFSLVLLLIGGVAASKNLHKPLLHNVLRNPLSYFDITPIGRIINRLAKDM 1051

  Fly   836 GQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEA 900
            ..||..:.:.....:...:.:...:.::..|.|.::.....:.:.:::...:.:|::|.::|:.:
Worm  1052 EVVDLRLSSSFRFLVMALINMVQTVLIVSYTTPLFIAIIIPVFIIYFFVLKYSIKSTRQLQRIAS 1116

  Fly   901 VARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAY 965
            :.|||::|:||.||.|:.|:||.......:.:.|.:.:.|....|.....:|.....|:|.....
Worm  1117 LTRSPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYSQMANRWLSIRLELLGNIV 1181

  Fly   966 VIS-VILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEG 1029
            :.| .||..........||.:||:::.:|.:|.|:...:||..|:|..:.||||:.||.....|.
Worm  1182 IFSAAILAIIGKESGITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSKTKSEA 1246

  Fly  1030 DFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSL 1094
            ::... ....|.:||..|.:..:|.|.||..:.:  .|||.:|..|.|.:|||:.||||||||||
Worm  1247 EWRLD-NNNLPSNWPTGGAVNIEDYSCRYRDELD--LVLKQISLNILPGQKVGVCGRTGAGKSSL 1308

  Fly  1095 INALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWK 1158
            ..||||: ...||.|.||...|:.|||||||.|::|||||.|||:.|:|:|:||..|:.|.:||.
Worm  1309 ALALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWL 1373

  Fly  1159 ALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDA 1223
            |||:.:||..:..||..|:|.::|||.|||||||||:||.||:||::::||:|||||.:|.:||.
Worm  1374 ALENSNLKAHVELLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDT 1438

  Fly  1224 LIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGM 1283
            ::|||||.||.|.|::||||||:||:|.|:::|||||.:||.|.|.||| .::...|:|:
Worm  1439 MVQATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELL-KNRNSQFYGL 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	441/1348 (33%)
		ABC_membrane	112..364	CDD:294371	77/257 (30%)
		ABCC_MRP_domain1	434..632	CDD:213217	90/200 (45%)
		ABC_membrane	736..955	CDD:294371	52/237 (22%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	123/221 (56%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	444/1360 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810