DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and mrp-4

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_509658.1	Gene:	mrp-4 / 181202	WormBaseID:	WBGene00003410	Length:	1573	Species:	Caenorhabditis elegans

Alignment Length:	1406	Identity:	472/1406 - (33%)
Similarity:	750/1406 - (53%)	Gaps:	175/1406 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAAS-LGDEFFQGWE------DE 65
            |:|..::..|:.:...:...:...|.|:.|:.:||| :|||.:.:: |..:::..|:      :|
Worm   216 PSPETTSSFLNRITMWWFNSLCSLGVKKPLEVSDLY-SLNEADTSNLLVPKWYNLWDKQSKKFEE 279

  Fly    66 VARCRRKGDSG-----------------------------------RKPSVLRVIGRVFGWRLIM 95
            .|..||.|.:.                                   :.||::..:..:|.|.:
Worm   280 TAARRRIGSNASRTNRRRTSSNDTTPLLNDQSTDDYGSVPAGQSTQKMPSIIWTLFLMFKWDV-- 342

  Fly    96 SGITIAALELGTRATV---PLLLAGLISEFSEHGNGHSYNAQIYA-VLLIACILASVLLTHPYMM 156
              ||...::|.:...:   ||||..|| .|:|......:...:.| .:..:..|:|:||:| |..
Worm   343 --ITAMFVKLLSDVLLFCNPLLLKSLI-RFTEELERPMWQGVVLAFTMFFSAELSSILLSH-YFY 403

  Fly   157 GMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLEL 221
            .|..:..:::..:::|:|||.||||..:....|.|::|||::.|::||.:........|..|.::
Worm   404 LMYRVGTRVQTCLTAAVYRKTLRLSNAARREKTVGEIVNLMAIDVDRFQQITPQTMQYWSNPFQI 468

  Fly   222 LIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIK 286
            .:|.:.|::|:|::.|.|::::||..|:...::.:..|.::......|:|.:|:||:::||:|||
Worm   469 GLALFLLFQQLGVSVFSGVAVMVLLFPINFVITMIIRKWQIAQMYYKDERTKMVNEVLNGIKVIK 533

  Fly   287 MYTWERPFGKLIGQMRRSEMSSIRQMNLLRGI--LLS----FEITLGRIAIFVSLLGFVLGGGEL 345
            :|.||.|..::|..:|..|:..|::...||..  :|:    |.:.|...|.|:    ::.....|
Worm   534 LYAWEPPMEQVIEDLREQELGLIKKAAFLRTFSDMLNTASPFLVALSTFATFI----YIDPKNVL 594

  Fly   346 TAERAFCVTAFYNILRRTVSKFFPSGMSQFAELL-------VSMRRITNFMMREEANVIDMSERR 403
            |.|.||.....:|.||        |.|||.|||:       ||.||:..|::.||.||    |..
Worm   595 TPEIAFVSLTLFNQLR--------SPMSQVAELITQTVQVVVSNRRLKEFLVSEELNV----EAI 647

  Fly   404 DEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLV--LNNVNMSLRRGQLVA 466
            |.:|                    ::.:.::.:|.....|...:|..|  |.|::.|:.|||||.
Worm   648 DHRA--------------------RDNNDVICLKEACLSWESAEHQPVPTLTNISFSVNRGQLVT 692

  Fly   467 VIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTV 531
            ::|.||:||||::||::||:...|||:.:.|:..|..|:||:.|.::|.||.||...|:..|..|
Worm   693 IVGRVGAGKSSMLQALMGEMEKLSGSISMHGRLCYVPQQPWMQNNTLRQNITFGKQFDEYFYSRV 757

  Fly   532 LKRCALERDLELLH-GDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRH 595
            |..|||.|||::|. ||.|.:||:|.:|||||:|||.||||||:..|:||||||:||||.|||..
Worm   758 LDACALYRDLQILPLGDNTEIGEKGINLSGGQKARISLARAVYQNHDIYLLDDPMSAVDAHVGSQ 822

  Fly   596 LFDECM--RGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLV--- 655
            ||...:  .|.|..:..||||::|.|||.:|||::|::|.:...|.|:::::.|. |.|||:
Worm   823 LFGSVIGPEGMLRNKTRILVTNELSFLEKSDLIIVMNEGKIEYSGKYDDLMQQGA-FEQLLIECE 886

  Fly   656 --------------ESTQNSGGG-------------DEIITSPNLSR--QSSALSTKSSNGSSSS 691
                          |..:||..|             |:::.||.:..  .:|.:||.|...:...
Worm   887 KEERERREAEASADEDDENSEPGGIMIGGDSDFEYDDDVMASPIIDHVLGTSHMSTVSGIINRRR 951

  Fly   692 LESMVEKEKPKPSAVSSQ-----------------ESRSGGQIGLSMYKKYFGAGCGVLVFVVLI 739
            :.:...|::.:.|...|.                 |....|::.:..|.||||| .|:.:.|:.:
Worm   952 ISTSTHKQRRRLSTTKSHTHSITSASTQTRQLTGTERVETGRVKMDTYYKYFGA-MGMSIAVLFV 1015

  Fly   740 MLCIGTQILASGGDYFLSYWVKNTASSS-----------TLDIYYFTAINVGLVICALLRTLLFF 793
            :....:.|.:.|.:.:|:.|..:.|:.|           .|.:|.....:..:::...:.:||:.
Worm  1016 LGMTTSTIFSMGRNLWLTDWSNDNAARSGSNTTGQPIAIRLGVYAGLGFSEIILLFIGMLSLLYG 1080

  Fly   794 NITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTG 858
            .::  :|..||..:.:.|.|..:.|:.|.|.||||||...|:..||.::|..:....|..|.:..
Worm  1081 GVS--ASRNLHAPLMRNLFRVPMAFYDTTPFGRILNRIGKDIETVDVLLPFNVQFFAQCLLQVVS 1143

  Fly   859 IICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAM 923
            .:.::.::.|.:.|....:.:.:.....:|:.|||.:||||::.|||:|||.|.::.|..||||.
Worm  1144 TLIIIMISTPVFGIVIIPLSVMYLMVMRYYIATSRQLKRLESITRSPIYSHLSESIQGSATIRAY 1208

  Fly   924 GAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLA 988
            ..........:...|.|....|.....:|.....|:......|:...|..........:|.|||:
Worm  1209 HLVDRFCKLSETKVDSHVQCRYLNYVANRWLSVRLEFIGNCIVLFSALFAALTRTTTTSGVIGLS 1273

  Fly   989 ITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKD 1053
            ::.||.:|.::.:.:||..:||..:.|||||.||.:.:.|.::.|...|:||::||.||::|..:
Worm  1274 VSYALNITTVLNFAVRQITKLETNIVSVERVKEYAETETEAEWKSEPGKEPPQNWPSEGRIVMNN 1338

  Fly  1054 LSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR-LSYNDGAILIDSLDTND 1117
            .|.||.|..|  .|:|.|:..|:|.|||||||||||||||:..:||| :...:|.|::|.::..:
Worm  1339 YSARYRPGLN--LVVKQLNVEIKPHEKVGIVGRTGAGKSSVTLSLFRIIEAAEGQIVVDGINLAE 1401

  Fly  1118 IGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISE 1182
            ||||||||.::||||:|||||||:|:|||||..|.|..:||.||..:|||..:.....|..||:|
Worm  1402 IGLHDLRSNLTIIPQDPVLFSGTLRFNLDPFNHYSDGDIWKTLEMANLKEFATAHNEQLNYIITE 1466

  Fly  1183 GGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNT 1247
            ||.|.|||||||||||||:||:.|:|::|||||.||..||||||.|||.:|.:.|||||||||||
Worm  1467 GGDNISVGQRQLVCLARALLRKTRVLILDEATAAVDVSTDALIQKTIREEFANATVLTIAHRLNT 1531

  Fly  1248 IMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTG 1288
            |||.|:::|::.|.|.||.||..|| :::...|:.|..:.|
Worm  1532 IMDYDRIIVLNDGKVGEFDSPANLL-SNRNSEFYSMAKRAG 1571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	468/1389 (34%)
		ABC_membrane	112..364	CDD:294371	77/258 (30%)
		ABCC_MRP_domain1	434..632	CDD:213217	98/202 (49%)
		ABC_membrane	736..955	CDD:294371	57/229 (25%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	128/221 (58%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	472/1406 (34%)
		ABC_membrane	346..613	CDD:294371	79/280 (28%)
		ABCC_MRP_domain1	658..862	CDD:213217	98/203 (48%)
		ABC_membrane	1012..1259	CDD:294371	60/248 (24%)
		ABCC_MRP_domain2	1332..1552	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820