Protein Alignment CG31793 and mrp-6

DIOPT Version :9

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_001362008.1
• Gene: mrp-6 / 180691
• WormBaseID: WBGene00003412
• Length: 1415
• Species: Caenorhabditis elegans
• Alignment Length: 1385
• Identity: 478/1385 - (34%)
• Similarity: 733/1385 - (52%)
• Gaps: 122/1385 - (8%)

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRK-QTLQPTDLYKTLNEHEAASLGDEFFQG-WEDEVARCR 70
            |:..:|||::||::|.|.....::.|. ||  .|||.:..::..:|....:..:. |.
 Worm    45 PSSEDSAGLISSILFSFVGFYWWRTRNAQT--DTDLLEKPSKGISAKYAAQKLESKWI------- 100

  Fly    71 RKGDSGRKPSVLRVIGRVFGWRL----IMSGITIAALELGTRATVPLLLAGLISEFS-EHGNGHS 130
               .||.|    |....|..|..    :|:......||..||...||||..|:|.:. |.|....
 Worm   101 ---SSGPK----RTHFLVGVWHCTKVSVMAHAISLCLEELTRVAQPLLLRELMSYYDIEEGQEFP 158

  Fly   131 YNAQIYAVLLIACI-LASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVV 194
            |...:...|:|:.: ..:|.:.|||..|::.:....|||....:|||:||:|.|||..|.:||::
 Worm   159 YWPAMQVALIISLLSFVTVCIHHPYFHGLLKVGNHARVATGVLLYRKSLRISLTSLFETNSGQII 223

  Fly   195 NLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSK 259
            .||:.|..:.::..:..|::||.||.:...:|.|:...|.....|..:::..:..|.:.|.....
 Worm   224 QLLNTDAAKLEQAFLFAHYVWLCPLLMFFYAYILWSMFGFCCLLGFLVMMAIVSFQVHYSYQLGV 288

  Fly   260 LRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEI 324
            .|.....:.|.|:::|:|||:||:||||:.||..|.:.|..:|..|:.::........:::....
 Worm   289 NRRNIGDKMDSRLKVMSEIINGIKVIKMHGWENAFAEKIRILREDEIKAVGTSAFYSSMVMGIYF 353

  Fly   325 TLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFM 389
            ...:|.:||.:.........||....|..:|.:|.:|...:.|.|.|:....||..:.|||..|.
 Worm   354 ISAKIGLFVYIFACDYFDEILTTRGVFASSALFNSVRLPFALFLPLGLLFGRELFSTSRRIDLFF 418

  Fly   390 MREEANVI----DMSERRD-EKAEEEQHLLKEV-EKRSYPVGIGKEPDTLVEIKALRARW-GQEQ 447
            ..||.:.|    |.::..| .|.|:|...||:: ||.|:.:...|...|.|.:..:.|.| .:::
 Worm   419 CLEEYSRITLELDSTDTEDGSKNEKEGLTLKKIGEKPSWTLKCDKAEKTSVFLNKVTAVWYDKDE 483

  Fly   448 HD-------------------------------LVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQA 481
            ||                               ..:.:::.....|....:||.||||||||:..
 Worm   484 HDQKKKKKNFKALSDNDATVIAGEKKDEPLHVVYAVQDLSFEFVAGTCYGIIGSVGSGKSSLLLT 548

  Fly   482 ILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLH 545
            ||.|.....|::.|:|.::|.:||||:|..|::|||:||...:|:||...|:.|.|..|| :..:
 Worm   549 ILSESRMTRGNLSVNGSFAYCAQEPWIFTGSIQDNIVFGSEFNKERYENALELCLLTPDLRQFAN 613

  Fly   546 GDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLV 610
            ||.||||:.|::||||||||:.||||||..||:|||||||||||.|||:.|::..:||||..:||
 Worm   614 GDMTIVGDNGSTLSGGQRARVALARAVYADADIYLLDDPLSAVDAHVGKKLYENLIRGFLSDKLV 678

  Fly   611 ILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKS--GQDFAQLLVESTQNSGGGDEI-ITSPN 672
            ||||||:.||.:.|.:::|....:...|:.:| |||  ..||.:|  ::.:.....||: :..|.
 Worm   679 ILVTHQIHFLSELDSVILMKNNKMVGNGSLDE-LKSTFTDDFIKL--QAVETEVQSDELFVDGPP 740

  Fly   673 LSRQSSALSTKSSN-----------GSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYF 726
            .|...|.::.:|..           .|..|...|.|.|..|...   .|||..|.|..|:|.:|.
 Worm   741 SSPPPSPVNIESMEKINKESIFQRANSVLSGSKMSETEYVKEIV---YESRKSGTISWSVYWEYT 802

  Fly   727 GAGCGVLVFVVLIMLCI-GTQILASGGDYFLSYWV----KNTASSST--------LDI------- 771
            ......|.:.:.:::|: .||::.:..|::|:.|:    .|.|.:||        :|:
 Worm   803 RGVINPLKYGIWLVVCVLITQLMNNFVDWWLNKWLVDLDMNNADNSTSKEEFNRNVDVLGYTFNV 867

  Fly   772 ----YYFTAINVGLVICALL---RTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILN 829
                |..|.| :..||.::|   |::.|.|..:.:|..|||:||..:.:|...||..|..|.|||
 Worm   868 TFQTYELTFI-ISTVIMSILGVVRSVWFRNAQLMASRILHNSMFDCVLKTESEFFDKNSEGMILN 931

  Fly   830 RFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRD 894
            ||:.|:|..|:::.....:.:...||..||:.::.:..|..::....:...||:.|..|:..||:
 Worm   932 RFSKDIGLTDDLLAFTYFEFVFGTLTFVGIVGLVSMVRPIVILACAFITAGFYFCRKMYVHRSRE 996

  Fly   895 VKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLD 959
            :||:||.||||:.:..::|:.||.||||...:..:|.::....|::.:.|...:.::|.||..:|
 Worm   997 LKRIEAAARSPLNTTITSTVHGLSTIRAYRKENEMIEKFCALHDVYMAAYNMGLLSARWFGICID 1061

  Fly   960 LFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKD 1024
            .....:|..|.:...........|::||.:..|:.::|...|.|||||||||.|.||||||||..
 Worm  1062 FLVSVFVSIVAIVVVLQYETLTVGEVGLCLVCAVQLSGFFSWIMRQSAELENGMVSVERVLEYTK 1126

  Fly  1025 LDPEGDFNSP----AEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVG 1085
            |..|.:...|    .:||...|||.:|::..:::|:.|    ....|||.|||.:...:|:|:||
 Worm  1127 LKSEEEARRPHDAYLDKQLLNSWPTKGEIEFENVSVNY----GETKVLKNLSFVVLGGQKIGVVG 1187

  Fly  1086 RTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFE 1149
            |||||||:||..:|.| .|..|.:.||.:|.:.|.|:..|..:||||||||:||||:|.|||||:
 Worm  1188 RTGAGKSTLIKIIFGLKEYCSGRVTIDGVDLDHISLNFRRGGMSIIPQEPVIFSGTVRENLDPFD 1252

  Fly  1150 QYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEAT 1214
            :|.|..:|.|||...||..|:: ..||...:.:.|.:.|||||||.|||||::..::|||:||||
 Worm  1253 EYDDATIWFALEQCELKRSITK-EKGLNVELGQRGVSLSVGQRQLFCLARAMIHRSKILVIDEAT 1316

  Fly  1215 ANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKV 1279
            ||||..|||.||.|||:.||:.|::|:||||:|||:||.|:|.:.|.:|||..|..||. .::.:
 Worm  1317 ANVDGVTDACIQKTIRDFFKNATIITVAHRLHTIMNSDNVMVFEKGELVEFDKPITLLD-DQSSL 1380

  Fly  1280 FHGMVMQTGKASFDHLLKVA 1299
            |..|..|:|..:||.|...|
 Worm  1381 FSRMAAQSGAENFDSLRAAA 1400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	469/1357 (35%)
		ABC_membrane	112..364	CDD:294371	73/253 (29%)
		ABCC_MRP_domain1	434..632	CDD:213217	96/230 (42%)
		ABC_membrane	736..955	CDD:294371	69/245 (28%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	112/221 (51%)
mrp-6	NP_001362008.1	MRP_assoc_pro	<126..1389	CDD:188098	450/1275 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I2739
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.920