DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and mrp-2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_508121.1	Gene:	mrp-2 / 180408	WormBaseID:	WBGene00003408	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1354	Identity:	466/1354 - (34%)
Similarity:	729/1354 - (53%)	Gaps:	123/1354 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNE-HEAASLGDEFFQGWE---DEVARCR 70
            |..:|..::.|.|.:...:.:.|.|::|:..||: .||| .:|.:|...|.|..:   ||..:..
Worm   208 PEYTASFINRLTFQWFTGLAYLGNKKSLENEDLW-DLNEIDKAENLIPSFMQNLKPRIDEYHQNI 271

  Fly    71 RKGDSG----RKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSY 131
            :|..|.    ..||.:..|.:.:.:.|:.........:: .:...|.||..||....:.......
Worm   272 KKDPSAALPKNHPSFVIPIFKTYKYTLLAGFFYKLCFDM-LQFLAPQLLKQLIGFIEDKNQPVWI 335

  Fly   132 NAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNL 196
            ...|..::..:..|.|:.| |.|...|..|.|.:|..::||:|.|||.||..:..|.|.|.:|||
Worm   336 GCSIVGIMFFSSFLQSMFL-HQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKGKTIGAIVNL 399

  Fly   197 LSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLR 261
            :|.|:.:...........|..||::.::.|||::.:|:|:..|:.:|:|.||:...::....|.:
Worm   400 MSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPVNGLIAIQMRKCQ 464

  Fly   262 LQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITL 326
            .:.....|:|::||:||::|::|:|:|:|||....::.::|..|:..:::::.....::...|..
Worm   465 TEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKLSYFMAAIVFSWICA 529

  Fly   327 GRIAIFVSLLGFVLGGGE---LTAERAFCVTAFYNILRRTVSKFFPSGM-----SQFAELLVSMR 383
            ..:|..:|.:.:|....|   ||.|..|...:.::|||      .|..|     .:..:..||..
Worm   530 PFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILR------MPLAMVAMVYGEAVQCSVSNT 588

  Fly   384 RITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQH 448
            |:..|...||     ||.:..                   :..| |.|:.:|::.....|..::
Worm   589 RLKEFFAAEE-----MSPQTS-------------------ISHG-ETDSAIEVENGLFSWSSDE- 627

  Fly   449 DLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASV 513
            |..|..::..:::|||||::|.||||||||:.|:|||:...|||||::|..:|..|:.|:.|.|:
Worm   628 DPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSL 692

  Fly   514 RDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTIVGERGASLSGGQRARICLARAVYRRAD 577
            |:||||..|.|.:.|..|:|.|||:.|| .|..||.|.:||:|.:|||||:.|:.||||||:..|
Worm   693 RNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPD 757

  Fly   578 VYLLDDPLSAVDTHVGRHLFDECM---RGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGT 639
            :.||||||||||:|||:|:|:..:   .|.|..:..:||||.|.:|:..|.::::.:|.:|..||
Worm   758 IILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLIVLKEGTISELGT 822

  Fly   640 YEEMLKSGQDFA----QLLVESTQ----------NSGGGDEII-----TSPN-LSRQSSALSTKS 684
            |:|:|.:...||    :.|:|.::          .||..|||:     ..|. |.|..|.||.:|
Worm   823 YQELLNNSGAFAEFLEEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVKPGILKRLESHLSQES 887

  Fly   685 SNGSSS------------------SLESMVEKEKPKPSAVS------------SQESRSGGQIGL 719
            ....:|                  |..|..|:.:....|:|            .:|:...|::..
Worm   888 DKEDTSARAIEYSRDSSRRSVLLHSPRSQHEENEALLGAISEDVPAQENTQLIEKETVETGKVKF 952

  Fly   720 SMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYF---LSYWVKN---TASSSTLDIYYFTAIN 778
            .:|..||.| ..:.:.::...|.:|:..|....:::   ||...|:   |:|.:.:::..:..:.
Worm   953 EVYIAYFQA-ISIPITLLFFFLYVGSSGLGILSNFYLAKLSDHAKSGNRTSSDAKMELGIYAVLG 1016

  Fly   779 VGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMP 843
            :|.....|:.:::.....:.:|..||..:...:.|:.:.||...|.||||||...|:..:|..:|
Worm  1017 MGQSFVVLIASIILTIGVLRASRILHAGLLGNIMRSPMAFFDVTPIGRILNRIGKDIEAIDRTLP 1081

  Fly   844 AVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYY-WRDFYLKTSRDVKRLEAVARSPMY 907
            .|:.........:...:.|:....||..| .||::...|: ...||:.|||.:||||:.:|||:|
Worm  1082 DVIRHMSMTIFNVVATLVVIMWATPWAGI-AFAILSVIYFIVLRFYISTSRQLKRLESASRSPIY 1145

  Fly   908 SHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVISV--I 970
            |||..::.|..:|||.|.....|.|.....|.|...||..:..:|.....|::.....|:|.  .
Worm  1146 SHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYYPSIVANRWLAVRLEMVGNLIVLSAAGA 1210

  Fly   971 LHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDFNSPA 1035
            ...|.:.|..:||.:||:::.||.:|..:.|.:|.::|||..:.||||:.||.....||: ||
Worm  1211 AVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVERIKEYTVTPTEGN-NS-- 1272

  Fly  1036 EKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR 1100
            .:...||||::|::..|:.|:||.|..:  .||.|:|..|.|.||||||||||||||||..||||
Worm  1273 RRLAAKSWPEKGEISIKNFSVRYRPGLD--LVLHGISAHIAPSEKVGIVGRTGAGKSSLTLALFR 1335

  Fly  1101 LSYND-GAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVH 1164
            :...| |:|.||.::..::.|..|||.::|:||:||||||||:.|||||..|.|.::|:|||:.|
Worm  1336 IIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFSAYSDSQVWEALENAH 1400

  Fly  1165 LKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATI 1229
            ||..:..|..||:..|||||.|.|||||||:|||||:||:.::||:|||.|.||.:||:|||.||
Worm  1401 LKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLIQKTI 1465

  Fly  1230 RNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGM 1283
            |.:||:||||||||||||:||||::||:|.|.|.||.||..|| |:...:|:.|
Worm  1466 REQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLL-ANPDGIFYSM 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	462/1342 (34%)
		ABC_membrane	112..364	CDD:294371	72/254 (28%)
		ABCC_MRP_domain1	434..632	CDD:213217	92/201 (46%)
		ABC_membrane	736..955	CDD:294371	62/225 (28%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	130/221 (59%)
mrp-2	NP_508121.1	MRP_assoc_pro	25..1522	CDD:188098	466/1354 (34%)
		ABC_membrane	309..570	CDD:294371	72/268 (27%)
		ABCC_MRP_domain1	614..816	CDD:213217	92/202 (46%)
		ABC_membrane	971..1239	CDD:279056	74/268 (28%)
		ABCC_MRP_domain2	1284..1504	CDD:213211	130/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820