DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and mrp-7

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1368	Identity:	458/1368 - (33%)
Similarity:	726/1368 - (53%)	Gaps:	139/1368 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASKLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQG-WE--- 63
            :||...:|...:..|:.|...:...|.:.|.::.|:..|::: |||........|.::. ||
Worm   201 SSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFE-LNERSGTEFLSELWESFWEPKR 264

  Fly    64 ----DEVARCRRKGDSGRK------PSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGL 118
                .:.:...:|..|.::      |||:..:..:|.|..:::. |:..:....:...|.||..|
Worm   265 LKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLAS-TLKFVSDTMQFASPFLLHEL 328

  Fly   119 ISEFSEHGNGHSYNAQIYAVLLIACILASV-----LLTHPYMMGMMHLAMKMRVAVSSAIYRKAL 178
            ::..|      :.||..:..:.::.::.||     |:.:.|...|..:..|::.::::|:|:|.|
Worm   329 LNFIS------AKNAPFWKGMALSILMFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTL 387

  Fly   179 RLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISIL 243
            .:|.::....|.|::|||::.|:.||..........|..|.::..|..:|:..:|.::..|:.|:
Worm   388 LISNSARRDRTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIM 452

  Fly   244 VLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSS 308
            |:::|:....|.:..|.:::.....|:|.:|:||:::||:|:|:|.||.|....|.::|..|::.
Worm   453 VIFVPMNIISSMIVRKWQIEQMKLKDERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELAL 517

  Fly   309 IRQMNLLRGILLSFEITLGRIAIFVSLLGFVLGGGE--LTAERAFCVTAFYNILRRTVSKFFPSG 371
            |::..::|.||.||......:....|...|||....  ||.:.||...|.:|.||..:: .....
Worm   518 IKKSAMVRNILDSFNTASPFLVALFSFGTFVLSNPSHLLTPQIAFVSLALFNQLRSPMT-MIALL 581

  Fly   372 MSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEI 436
            ::|..:.:||.:|:..|::.||.         |||..:          ||..:   :.....|.:
Worm   582 INQAVQAVVSNKRLKEFLVAEEL---------DEKCVD----------RSVNI---ERSHNAVRV 624

  Fly   437 KALRARWGQEQ--HDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKY 499
            :.|.|.|..|:  .:..|.:|:::..|..|:||:|.||||||||:||:|||:....|.:.|:|:.
Worm   625 ENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVNGRV 689

  Fly   500 SYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQR 563
            :|..|:||:.|.::||||.||.|.|::||..||..|||:.|:::| .||.|.:||:|.:|||||:
Worm   690 AYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSGGQK 754

  Fly   564 ARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILVTHQLQFLEDADLI 626
            ||:.||||||:..|||||||||||||.|||||:|::.:  .|.|.::..|||||.|.:.:.||.|
Worm   755 ARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMADEI 819

  Fly   627 VIMDKGHVSACGTYEEMLKSGQ---DFAQLLVESTQNSG-------------GG----------- 664
            ::|.:|.:...||:|.::|...   ||.:.....:.||.             ||
Worm   820 LVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNPEDV 884

  Fly   665 --------DEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSM 721
                    ||.|.:|.|:.|.|.:|:.....:.:|..:..|.:    :.:..:|..:.|::.::.
Worm   885 VLTVTNDLDETIRTPELTTQISTMSSPEKPPTGTSPAAATESQ----NKLIKKEGIAQGKVEIAT 945

  Fly   722 YKKYFGAGCGVLV---FVVLIMLCIGTQILASGGDYFLSYW----------VKNTASSSTLDIYY 773
            |:.|..| .|.|:   |:...::.:..|||.|   ::||.|          ....|....|.:|
Worm   946 YQLYVKA-AGYLLSIAFIGFFIVYMTLQILRS---FWLSAWSDEYDPDSPSAHPMAKGWRLGVY- 1005

  Fly   774 FTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQV 838
             .|:......|..:..|....:...:|..||..:...|.|:.:.|:.|.|.||||||.|.|:..:
Worm  1006 -GALGFSETACFFVALLALVFVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKDIETI 1069

  Fly   839 DEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVAR 903
            |.::|......:...|.:...:.|:.::.|.:.:....:.|.:..:..:|:.|||.:||||:|.|
Worm  1070 DMMLPMNFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHR 1134

  Fly   904 SPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLF--CVAY- 965
            ||:||||..|:.|..:|||.|.............|......|:.:.::|.....|:..  |:.:
Worm  1135 SPIYSHFGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSLVSNRWLAVRLEFVGNCIIFF 1199

  Fly   966 -VISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEG 1029
             .:..:|...|. .:.:.|.||::::.||.:|.::.:.:||.:|:|..:.|||||.||.
Worm  1200 AALFAVLSKEFG-WITSPGVIGVSVSYALNITEVLNFAVRQVSEIEANIVSVERVNEYT------ 1257

  Fly  1030 DFNSPAE-------KQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRT 1087
              |:|.|       ::|...||..|.:.....|.||....:  .||..:|..:...||:||||||
Worm  1258 --NTPNEAPWRIEGREPAPGWPSRGVVKFDGYSTRYREGLD--LVLHDISADVAAGEKIGIVGRT 1318

  Fly  1088 GAGKSSLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQY 1151
            ||||||...|||| :....|.|:||.::.:.||||||||.|:||||:|||||||:|:|||||..|
Worm  1319 GAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTY 1383

  Fly  1152 PDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATAN 1216
            .||::|:|||..|||...:.||.||...|||.|.|.||||||||.||||:||..|:||:|||||.
Worm  1384 SDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAA 1448

  Fly  1217 VDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFH 1281
            ||..||||||.|||.:||:|||.|||||||||||.|:::|:|.|.::||.:| :.|.|.|...|.
Worm  1449 VDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRIMVLDKGSILEFDTP-DALMADKNSAFA 1512

  Fly  1282 GMV 1284
            .||
Worm  1513 KMV 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	452/1355 (33%)
		ABC_membrane	112..364	CDD:294371	71/258 (28%)
		ABCC_MRP_domain1	434..632	CDD:213217	100/202 (50%)
		ABC_membrane	736..955	CDD:294371	60/228 (26%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	129/221 (58%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	458/1368 (33%)
		ABC_membrane	310..575	CDD:294371	71/270 (26%)
		ABCC_MRP_domain1	622..826	CDD:213217	100/203 (49%)
		ABC_membrane	976..1227	CDD:279056	64/256 (25%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	129/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750