DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31793 and haf-2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_495537.2	Gene:	haf-2 / 174204	WormBaseID:	WBGene00001812	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	682	Identity:	160/682 - (23%)
Similarity:	301/682 - (44%)	Gaps:	112/682 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AGILSSLMFCFALPILFKGRKQTLQPTDLYKTLN---EHEAASLGDEFFQGWED-EVARCRRKGD 74
            :|.:..|::.|..         |..|.|.::.||   |:...|:.:...:...| |.|.....|.
Worm   130 SGFIQVLVWYFVF---------TSNPFDYHRLLNTTAENAGTSVTETAAETVRDTETASNVESGS 185

  Fly    75 SGRKPSVL-RVIGRVFG-----WRLIMSG---ITIAALELGTRATVPLLLAGLISEFSEHGNGHS 130
            |....:.| :|:.|:..     |....||   :|:.||   .|..:|...|.:||:..   |...
Worm   186 STAPRAPLHKVLLRLLSYCGHQWPWFASGFVFLTVYAL---ARVFIPNYTAQVISDIV---NKRG 244

  Fly   131 YNAQIYAVLLIACILASVLLTHPYMMGMMHLA-----MKMRVAVSSAIYRKALRLSRTSLGGTTT 190
            ..|.|::::::.|:.|:..|......|....|     :::|:.:.:::.|:.:....|:..|.|.
Worm   245 IQALIHSIIVLTCLTATSSLFGGLRGGCFDYATALVTLRIRLDLFTSLIRQDIAFYDTAKTGDTM 309

  Fly   191 GQ-------VVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISIL-VLYL 247
            .:       :.:.:|.::|.|.|..:    :.:|.|..:|   .:..::.|.:|..:.:: .:..
Worm   310 SRLTSDCQTISSTVSTNVNVFMRNGV----MLIGALAFMI---LMSWRLAMVTFIAVPLVGFITK 367

  Fly   248 PLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSE--MSSIR 310
            ...::..:::.||: ||...|:|   |..|::|.::.::.:..|:.      :::|.|  :||..
Worm   368 AYSSFYDKISEKLQ-QTIAETNQ---MAEEVVSTMRTVRSFACEKK------ELKRFEDRLSSTL 422

  Fly   311 QMNLLRGILLSFEITLGRI---AIFVSLLGFVLGGGELT----AERAFCVTAFYNILRRTVSKFF 368
            .:|..:.|...|.......   ||.|::|.:   ||.|.    .|:...:|.....::...:.::
Worm   423 SVNRKKSIAYLFYTWNNEFCDNAILVAVLFY---GGHLVMTGKMEKEQLITFLLYQMQLGENLYY 484

  Fly   369 PS-GMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDT 432
            .| .||...|.:.:.|::.:.|.|:....:|..:|                    |...|.
Worm   485 LSYVMSGLMEAVGASRKVFDLMNRKPQFELDGMQR--------------------PFVNGN---- 525

  Fly   433 LVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSG 497
             :....:...:....::.||.::.:|::.|:.||::||.|.||||::..|.....|:.|||.:.|
Worm   526 -ITFSHVGFTYPSRPNNPVLKDLTLSIKSGETVALVGPSGGGKSSIVSLIEHFYEPDEGSVTLDG 589

  Fly   498 -------------KYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERD--LELLHGD 547
                         |.:..:|||.|:|.|||.|||:|.....:.......:.|...|  :||..|.
Worm   590 VPIKDINHVYYHQKVALVAQEPVLYNGSVRHNILYGCDFATEDDMLNASKMANVHDFVMELEKGY 654

  Fly   548 GTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVIL 612
            .|..||:|..:||||:.||.:|||:.|...|.:||:..||:||. ...|..:.:.....::.||:
Worm   655 DTNCGEKGVQMSGGQKQRIAIARALVRNPAVLILDEATSALDTE-SEALVQQALSRCAQERTVII 718

  Fly   613 VTHQLQFLEDADLIVIMDKGHVSACGTYEEML 644
            |.|:|..:|.|:.|.::.||.:...||:.|::
Worm   719 VAHRLSTIEKANKIAVIVKGCLVQMGTHTELM 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	160/682 (23%)
		ABC_membrane	112..364	CDD:294371	52/273 (19%)
		ABCC_MRP_domain1	434..632	CDD:213217	67/212 (32%)
		ABC_membrane	736..955	CDD:294371
		ABCC_MRP_domain2	1047..1268	CDD:213211
haf-2	NP_495537.2	3a01208	15..761	CDD:273363	160/682 (23%)
		ABC_membrane	215..478	CDD:279056	56/288 (19%)
		ABC_MTABC3_MDL1_MDL2	526..764	CDD:213216	72/226 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000