DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and Abcc3

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_542148.2	Gene:	Abcc3 / 140668	RGDID:	71101	Length:	1523	Species:	Rattus norvegicus

Alignment Length:	1370	Identity:	477/1370 - (34%)
Similarity:	737/1370 - (53%)	Gaps:	139/1370 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGW---------- 62
            |.|..|||..|.|.|.:...:...|.::.|:.:||:....|..:..:.....:.|
  Rat   206 PCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQKQQTQASGP 270

  Fly    63 -----------EDEV---ARCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPL 113
                       ||||   ||.:.|     |||.||.:.|.|...|:| |.....::.......|.
  Rat   271 QTAALEPKIAGEDEVLLKARPKTK-----KPSFLRALVRTFTSSLLM-GACFKLIQDLLSFINPQ 329

  Fly   114 LLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKAL 178
            ||:.|| .|.......::...:.|.|:........|:.|.:...:..:|:::|.|:...||||||
  Rat   330 LLSILI-RFISDPTAPTWWGFLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIYRKAL 393

  Fly   179 RLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISIL 243
            .::.:.....|.|::|||:|.|..||.......:.||..||::::|.|||::.:|.::..|::::
  Rat   394 TITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVI 458

  Fly   244 VLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSS 308
            ||.:||...:|......::|.....|.|:::|:||::||:|:|:|.||..|.:.:..:|:||:..
  Rat   459 VLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQSELQL 523

  Fly   309 IRQMNLLRGI------LLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKF 367
            :|:...|:.|      ...|.:||..:.::|.    |.....|.||:||...:.:|||:..:: .
  Rat   524 LRKGAYLQAISTFIWVCTPFMVTLITLGVYVC----VDKNNVLDAEKAFVSLSLFNILKIPLN-L 583

  Fly   368 FPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDT 432
            .|..:|...:..||::||.:|:.::|.         |.:..|.:.:               .|..
  Rat   584 LPQLISGMTQTSVSLKRIQDFLNQDEL---------DPQCVERKTI---------------SPGR 624

  Fly   433 LVEIKALRARWGQEQHDL--VLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQV 495
            .:.|......|.:   ||  .|:::|:.:.:|.||||:||||.|||||:.|:|||:....|:|.|
  Rat   625 AITIHNGTFSWSK---DLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAVSV 686

  Fly   496 SGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLS 559
            .|..:|..|:.|:.|.::::|:|||.||:.:||:..|:.|||..||::| .||.|.:||:|.:||
  Rat   687 KGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLS 751

  Fly   560 GGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILVTHQLQFLED 622
            ||||.|:.||||||..|:::||||||||||:||.:|:||:.:  .|.|..:..:||||.:.||..
  Rat   752 GGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQ 816

  Fly   623 ADLIVIMDKGHVSACGTYEEMLKSGQDFAQLL----VESTQNSGGG-------------DEIITS 670
            .|.|:::..|.::..|.|.|:|:....||..|    .:..|.:..|             |.:.|.
  Rat   817 TDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANEEVLLLEDTLSTH 881

  Fly   671 PNLS--------------RQSSALSTKSSNGSSSSLE---SMVEKEKP-----KPSAVSSQESRS 713
            .:|:              |:.|:||::....:...|:   |.:|||.|     :..|:..:|...
  Rat   882 TDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVPATQTKETGALIKEEIAE 946

  Fly   714 GGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTA-------SSSTLDI 771
            .|.:.||:|..| ....|:...:.:.:|..|...:|.|.:.:||.|..:..       :|..|.:
  Rat   947 TGNVKLSVYWDY-AKSVGLCTTLFICLLYAGQNAVAIGANVWLSAWTNDVEEHGQQNNTSVRLGV 1010

  Fly   772 YYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLG 836
            |....|..||::.....|::...|  .::..||..:.....|....||.|.|||||||||:.|:.
  Rat  1011 YATLGILQGLLVMLSAFTMVVGAI--QAARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKDIY 1073

  Fly   837 QVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAV 901
            .:|||:...:|.....|.|....|.|:..:.|.:.:....:.:.:.:.:.||:.|||.:||||:|
  Rat  1074 VIDEVLAPTILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLESV 1138

  Fly   902 ARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLF--CV- 963
            :|||::||||.|:.|...|||.|..|......|...|.:....|.:::::|..|.:::..  ||
  Rat  1139 SRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVV 1203

  Fly   964 --AYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLD 1026
              :.:.:||..|..||     |.:||:::.||.:|..:.|.:|..::||:.:.:||||.||...:
  Rat  1204 LFSALFAVIGRNSLNP-----GLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTE 1263

  Fly  1027 PEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGK 1091
            .|..:...:.: .|:.||:.|.:..::.|:||.|...  .|||.|:..:|..|||||||||||||
  Rat  1264 TEAPWVLESNR-APEGWPRSGVVEFRNYSVRYRPGLE--LVLKNLTLHVQGGEKVGIVGRTGAGK 1325

  Fly  1092 SSLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDK 1155
            ||:...||| |...:|.|.||.|:...||||||||:::||||:|:|||||:|.|||||.:|.|:.
  Rat  1326 SSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDED 1390

  Fly  1156 LWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1220
            :|:.||..||...:|..|:||....||||.|.|||||||||||||:||::|:||:|||||.:|.:
  Rat  1391 IWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLE 1455

  Fly  1221 TDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVM 1285
            ||.|||.|||.:|:||||||||||||||||.::|||:|.|.|.||.||..|:.|  ..:|:||..
  Rat  1456 TDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAA--GGIFYGMAK 1518

  Fly  1286 QTGKA 1290
            ..|.|
  Rat  1519 DAGLA 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	471/1351 (35%)
		ABC_membrane	112..364	CDD:294371	76/257 (30%)
		ABCC_MRP_domain1	434..632	CDD:213217	92/202 (46%)
		ABC_membrane	736..955	CDD:294371	68/225 (30%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	131/221 (59%)
Abcc3	NP_542148.2	MRP_assoc_pro	7..1522	CDD:188098	475/1367 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750