DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31793 and Cftr

DIOPT Version :9

Sequence 1:NP_609930.4 Gene:CG31793 / 326161 FlyBaseID:FBgn0051793 Length:1307 Species:Drosophila melanogaster
Sequence 2:NP_066388.1 Gene:Cftr / 12638 MGIID:88388 Length:1476 Species:Mus musculus


Alignment Length:1466 Identity:397/1466 - (27%)
Similarity:700/1466 - (47%) Gaps:206/1466 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 NPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKG 73
            :|.|.|..:|.|.|.:..|||.||.:..|:.:|:|:..:...|..|.::..:.|:.|.|      
Mouse     4 SPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDREQA------ 62

  Fly    74 DSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIYAV 138
             |.:.|.::..:.|.|.||.:..||.:...|: |:|..|:||..:|:.:..........|....:
Mouse    63 -SKKNPQLIHALRRCFFWRFLFYGILLYLGEV-TKAVQPVLLGRIIASYDPENKVERSIAIYLGI 125

  Fly   139 LLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNR 203
            .|....:...||.||.:.|:..:.|:||.|:.|.||:|.|:||...|...:.||:|:||||:||:
Mouse   126 GLCLLFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNK 190

  Fly   204 FDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRT 268
            ||..|...||:|:.||::.:....|::.:..::|.|:.:|::.:..|..|.::..|.|.|.|.:.
Mouse   191 FDEGLALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVKYRDQRAAKI 255

  Fly   269 DQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFV 333
            ::|:.:.:|||..|..:|.|.||....|:|..:|..|:...|:...:|....|.....|...:|:
Mouse   256 NERLVITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFTSSAFFFSGFFVVFL 320

  Fly   334 SLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVID 398
            |:|.:.:..| :...:.|...:|..:||.:|::.||:.:..:.:....:|:|.:|:.::|..|::
Mouse   321 SVLPYTVING-IVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSFGMIRKIQDFLQKQEYKVLE 384

  Fly   399 MSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQH----------DLVLN 453
            .:..       ...::.|.....:..|.|:..:.:.:....|.....|.:          :.||.
Mouse   385 YNLM-------TTGIIMENVTAFWEEGFGELLEKVQQSNGDRKHSSDENNVSFSHLCLVGNPVLK 442

  Fly   454 NVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNIL 518
            |:|:::.:|:::|:.|..||||:||:..|||||....|.::.||:.|:.||..|:...::::||:
Mouse   443 NINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENII 507

  Fly   519 FGLPMDKQRYRTVLKRCALERDL-ELLHGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLD 582
            ||:..|:.||::|:|.|.|::|: :....|.|::||.|.:|||||||||.||||||:.||:||||
Mouse   508 FGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLD 572

  Fly   583 DPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSG 647
            .|...:|......:|:.|:...:..:..||||.:::.|..||.|:|:.:|.....||:.|:....
Mouse   573 SPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKMEHLRKADKILILHQGSSYFYGTFSELQSLR 637

  Fly   648 QDFAQLLV-----------------------------------------------ESTQNS---- 661
            .||:..|:                                               |..:||    
Mouse   638 PDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDSSAPWSKPKQSFRQTGEVGEKRKNSILNS 702

  Fly   662 ------------------GGGDEI---------------------------ITSPNLSRQSSA-L 680
                              |..|::                           .|.|...|||.. |
Mouse   703 FSSVRKISIVQKTPLCIDGESDDLQEKRLSLVPDSEQGEAALPRSNMIATGPTFPGRRRQSVLDL 767

  Fly   681 STKSSNGSSSSLE---------SMVEKEKPKPSAVSSQESRSGGQIGL----------------- 719
            .|.:.|..||:|:         |:|.:.......|.|:.......:.:                 
Mouse   768 MTFTPNSGSSNLQRTRTSIRKISLVPQISLNEVDVYSRRLSQDSTLNITEEINEEDLKECFLDDV 832

  Fly   720 ---------SMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSS-------- 767
                     :.|.:||....|:|:.::..:|....::.||   .|:.:.:||...:|        
Mouse   833 IKIPPVTTWNTYLRYFTLHKGLLLVLIWCVLVFLVEVAAS---LFVLWLLKNNPVNSGNNGTKIS 894

  Fly   768 ---------TLDIYYFTAINVG----LVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFF 819
                     :...||...|.||    |:..:|.|.|...:..:.:|..||..|...:....:...
Mouse   895 NSSYVVIITSTSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTI 959

  Fly   820 HTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYW 884
            ....:|.|||||:.|:..:|:.:|..:.|.||:...:.|.|.|:....|:..:.|...::.|...
Mouse   960 SKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVVSALQPYIFLATVPGLVVFILL 1024

  Fly   885 RDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVS 949
            |.::|.|::.:|:||:..|||:::|...:|.||.|:||...|......:....:||::.::.:::
Mouse  1025 RAYFLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYLA 1089

  Fly   950 TSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMT 1014
            |.|.|...:|:..|.:.|.|...:..... ...|..|:.:|.|:.:...:||.:..|.:.::.|.
Mouse  1090 TLRWFQMRIDMIFVLFFIVVTFISILTTG-EGEGTAGIILTLAMNIMSTLQWAVNSSIDTDSLMR 1153

  Fly  1015 SVERVLEYKDLDPEGDFNSPAEKQPPKS------------------WPKEGKLVTKDLSLRYEPD 1061
            ||.||.::.|:..|....:...|:.|:.                  ||..|::|.|||:::|..|
Mouse  1154 SVSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKSDIWPSGGEMVVKDLTVKYMDD 1218

  Fly  1062 TNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLSYNDGAILIDSLDTNDIGLHDLRSK 1126
            .|:  ||:.:||:|.|.::||::||||:|||:|::|..|:....|.|.||.:..|.:.|.:.|..
Mouse  1219 GNA--VLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGDIEIDGVSWNSVTLQEWRKA 1281

  Fly  1127 ISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQ 1191
            ..:|.|:..:||||.|.||||..::.|:::||..::|.||..|.:.|..|...:.:||...|.|.
Mouse  1282 FGVITQKVFIFSGTFRQNLDPNGKWKDEEIWKVADEVGLKSVIEQFPGQLNFTLVDGGYVLSHGH 1346

  Fly  1192 RQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLV 1256
            :||:||||::|.:.:|:::||.:|::||.|..:|:..::..|..|||:...||:..::|..:.||
Mouse  1347 KQLMCLARSVLSKAKIILLDEPSAHLDPITYQVIRRVLKQAFAGCTVILCEHRIEAMLDCQRFLV 1411

  Fly  1257 MDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKASF 1292
            ::..:|.::.|...||  |:..:|...:..:.|..|
Mouse  1412 IEESNVWQYDSLQALL--SEKSIFQQAISSSEKMRF 1445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31793NP_609930.4 CFTR_protein 1..1273 CDD:273530 392/1445 (27%)
ABC_membrane 112..364 CDD:294371 75/251 (30%)
ABCC_MRP_domain1 434..632 CDD:213217 78/208 (38%)
ABC_membrane 736..955 CDD:294371 59/239 (25%)
ABCC_MRP_domain2 1047..1268 CDD:213211 82/220 (37%)
CftrNP_066388.1 CFTR_protein 1..1464 CDD:273530 397/1466 (27%)
ABC_membrane 85..303 CDD:294371 69/218 (32%)
ABCC_CFTR1 389..670 CDD:213258 88/280 (31%)
CFTR_R 639..844 CDD:291094 23/204 (11%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 654..826 20/171 (12%)
ABC_membrane 861..1142 CDD:279056 70/284 (25%)
ABCC_CFTR2 1204..1464 CDD:213256 89/246 (36%)
Interaction with GORASP2. /evidence=ECO:0000250|UniProtKB:P13569 1382..1476 17/66 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1446..1476 397/1466 (27%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1474..1476
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.010

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