DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_000383.2	Gene:	ABCC2 / 1244	HGNCID:	53	Length:	1545	Species:	Homo sapiens

Alignment Length:	1390	Identity:	453/1390 - (32%)
Similarity:	736/1390 - (52%)	Gaps:	156/1390 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRR-- 71
            ||...|..|||:.:.:...|:.||.|:.|...|:::...|.:..:|..:|....:.|:.:.||
Human   193 NPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRAL 257

  Fly    72 --------------------------------------KGDSGRKPSV-----LRVIGRVFGWRL 93
                                                  |..||.|..|     ::.:.:.|...|
Human   258 QRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVL 322

  Fly    94 IMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGM 158
            :.|.:.....::.|..: |.||..||| |:...:.:.:...:.|:||....|........|....
Human   323 LKSFLLKLVNDIFTFVS-PQLLKLLIS-FASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLC 385

  Fly   159 MHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLI 223
            ..|.:|:|.|:.:::|:|||.||..:....|.|:.|||:|.|..:........|.||...|::::
Human   386 FKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVL 450

  Fly   224 ASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMY 288
            :.:||:.::|.:...|:.::||.:|:...||..:..::::.....|:|:::||||:|||:::|.:
Human   451 SIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYF 515

  Fly   289 TWERPFGKLIGQMRRSEMSSIRQMNLLRGILL-SFEITLGRIAIFVSLLGF-----VLGGGELTA 347
            .||..|...:..:|:.|:.::...:.|:.::: .|::|    .:.||::.|     |.....|.|
Human   516 AWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLT----PVLVSVVTFSVYVLVDSNNILDA 576

  Fly   348 ERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQH 412
            ::||.....:||||..:| ..|..:|...:..||..|:..::..::   :|.|..|.:
Human   577 QKAFTSITLFNILRFPLS-MLPMMISSMLQASVSTERLEKYLGGDD---LDTSAIRHD------- 630

  Fly   413 LLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHD--LVLNNVNMSLRRGQLVAVIGPVGSGK 475
                           ...|..::.......|   :||  ..:.:||:.:..||||||||||||||
Human   631 ---------------CNFDKAMQFSEASFTW---EHDSEATVRDVNLDIMAGQLVAVIGPVGSGK 677

  Fly   476 SSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERD 540
            ||||.|:|||:....|.:.:.|..:|..|:.|:.|.:::||||||...:::||:.||:.|||..|
Human   678 SSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPD 742

  Fly   541 LELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--R 602
            ||:| .||...:||:|.:|||||:.||.||||.|:..|:|||||||||||.|||:|:|::.:  .
Human   743 LEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPN 807

  Fly   603 GFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLL----------VES 657
            |.|..:..:||||.:.||...|.||::..|.:...|:|..:|....:||:.|          .|:
Human   808 GLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEA 872

  Fly   658 TQNSGGGDE-----IITS---------------PNLSRQSSALSTKSSNGSSSSLESMV------ 696
            |.:.|..:|     :|:|               .|..|::.:.|::|:.....||.:.:
Human   873 TVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVN 937

  Fly   697 ----EKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLS 757
                ::|..|...:..:|....|::..|:|.:|..| .|:.....:|:..:...:...|.:.:||
Human   938 SLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQA-IGLFSIFFIILAFVMNSVAFIGSNLWLS 1001

  Fly   758 YWVKNT---------ASSSTLDIYYFTAINVG---LVICALLRTLLFFNITMHSSTELHNTMFQG 810
            .|..::         ||...:.:..:.|:.:.   .|..|...:...|   :|:|..||..:...
Human  1002 AWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGF---VHASNILHKQLLNN 1063

  Fly   811 LSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTF 875
            :.|..:.||.|.|:|||:||||.|:..||:.:|..:...|..||.:...:.::|:..|.:.|...
Human  1064 ILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVI 1128

  Fly   876 AMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLH 940
            .:.:.:...:.||:.|||.::||::|.|||:|||||.|:.|||.|||...||..:...:...|.:
Human  1129 PLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTN 1193

  Fly   941 SSGYYTFVSTSRAFGYYLDLF-CVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMR 1004
            ....:::::::|.....|:|. .:....|.::...:...| :...:|..::.||.:|..:.|.:|
Human  1194 QKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTL-SGDTVGFVLSNALNITQTLNWLVR 1257

  Fly  1005 QSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLK 1069
            .::|:|..:.:|||:.||..::.|..:  ..:|:||..||.:||:...:..:||.|:.:  .||:
Human  1258 MTSEIETNIVAVERITEYTKVENEAPW--VTDKRPPPDWPSKGKIQFNNYQVRYRPELD--LVLR 1318

  Fly  1070 GLSFTIQPMEKVGIVGRTGAGKSSLINALFR-LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQE 1133
            |::..|..|||:|:|||||||||||.|.||| |....|.|:||.:|...|||||||.|::||||:
Human  1319 GITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQD 1383

  Fly  1134 PVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLA 1198
            |:||||::|.|||||..|.|:::|||||..|||..::.|..||...::|.|.|.|:|||||:||.
Human  1384 PILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLG 1448

  Fly  1199 RAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVV 1263
            ||:||:::|||:|||||.||.:||.|||.||:|:|..|||:||||||:||||||||:|:|.|.::
Human  1449 RALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKII 1513

  Fly  1264 EFGSPYELLTASKAKVFHGMVMQTG 1288
            |.|||.|||.....  |:.|..:.|
Human  1514 ECGSPEELLQIPGP--FYFMAKEAG 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	449/1373 (33%)
		ABC_membrane	112..364	CDD:294371	72/257 (28%)
		ABCC_MRP_domain1	434..632	CDD:213217	95/202 (47%)
		ABC_membrane	736..955	CDD:294371	64/230 (28%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	126/221 (57%)
ABCC2	NP_000383.2	SunT	8..1537	CDD:331423	453/1390 (33%)
ABCC2	NP_000383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..284		2/30 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850