DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and CFTR

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_000483.3	Gene:	CFTR / 1080	HGNCID:	1884	Length:	1480	Species:	Homo sapiens

Alignment Length:	1487	Identity:	411/1487 - (27%)
Similarity:	719/1487 - (48%)	Gaps:	239/1487 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRKG 73
            :|.|.|.::|.|.|.:..|||.||.:|.|:.:|:|:..:...|.:|.::..:.|:.|:|
Human     4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELA------ 62

  Fly    74 DSGRKPSVLRVIGRVFGWRLIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSYNAQIY-A 137
             |.:.|.::..:.|.|.||.:..||.:...|: |:|..||||..:|:.: :..|....:..|| .
Human    63 -SKKNPKLINALRRCFFWRFMFYGIFLYLGEV-TKAVQPLLLGRIIASY-DPDNKEERSIAIYLG 124

  Fly   138 VLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVVNLLSNDLN 202
            :.|....:...||.||.:.|:.|:.|:||:|:.|.||:|.|:||...|...:.||:|:||||:||
Human   125 IGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLN 189

  Fly   203 RFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALR 267
            :||..|...||:|:.||::.:....::|.:..::|.|:..|::....|..|.|:..|.|.|.|.:
Human   190 KFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGK 254

  Fly   268 TDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIF 332
            ..:|:.:.:|:|..||.:|.|.||....|:|..:|::|:...|:...:|....|.....|...:|
Human   255 ISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVF 319

  Fly   333 VSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVI 397
            :|:|.:.|..| :...:.|...:|..:||..|::.||..:..:.:.|.::.:|.:|:.::|...:
Human   320 LSVLPYALIKG-IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTL 383

  Fly   398 DMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDL------------ 450
            :.:....|       ::.|.....:..|.|:    |.|    :|:........
Human   384 EYNLTTTE-------VVMENVTAFWEEGFGE----LFE----KAKQNNNNRKTSNGDDSLFFSNF 433

  Fly   451 ------VLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLF 509
                  ||.::|..:.||||:||.|..|:||:||:..|:|||.|..|.::.||:.|:.||..|:.
Human   434 SLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIM 498

  Fly   510 NASVRDNILFGLPMDKQRYRTVLKRCALERDL-ELLHGDGTIVGERGASLSGGQRARICLARAVY 573
            ..::::||:||:..|:.|||:|:|.|.||.|: :....|..::||.|.:|||||||||.||||||
Human   499 PGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVY 563

  Fly   574 RRADVYLLDDPLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACG 638
            :.||:||||.|...:|....:.:|:.|:...:..:..||||.:::.|:.||.|:|:.:|.....|
Human   564 KDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYG 628

  Fly   639 TYEEMLKSGQDFA------------------QLLVESTQN-SGGGDEII----TSPNLSRQSSAL 680
            |:.|:.....||:                  .:|.|:... |..||..:    |.....:|:...
Human   629 TFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEF 693

  Fly   681 STKSSNGSSSSLESM---------------VEKEKPKP---------------------SAVSS- 708
            ..|..|...:.:.|:               :|::..:|                     |.:|:
Human   694 GEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTG 758

  Fly   709 ---------------QESRSGGQ---------------------IGLSMYKKYFGAGCGV----- 732
                           ..|.:.||                     ..|.:|.:......|:
Human   759 PTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEE 823

  Fly   733 -----------------------------------LVFVVL---------------IMLCIGTQI 747
                                               |:||::               ::..:|...
Human   824 INEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTP 888

  Fly   748 LASGGDYF----LSYWVKNTASSSTLDIYYFTAINVGLVICALLRTLLFFNITMHSSTELHNTMF 808
            |...|:..    .||.|..|::||....|.:..:...|:.....|.|...:..:..|..||:.|.
Human   889 LQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKML 953

  Fly   809 QGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLIN 873
            ..:.:..:...:|..:|.|||||:.|:..:|:::|..:.|.||:.|.:.|.|.|:.|..|:..:.
Human   954 HSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018

  Fly   874 TFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQD 938
            |..:::||...|.::|:||:.:|:||:..|||:::|...:|.||.|:||.|.|......:....:
Human  1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALN 1083

  Fly   939 LHSSGYYTFVSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGM 1003
            ||::.::.::||.|.|...:::..|.:.|:|...:..... ...|::|:.:|.|:.:...:||.:
Human  1084 LHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTG-EGEGRVGIILTLAMNIMSTLQWAV 1147

  Fly  1004 RQSAELENAMTSVERVLEYKDLDPEGDFNSPAEKQPPKS-------------------------W 1043
            ..|.::::.|.||.||.::.|:        |.|.:|.||                         |
Human  1148 NSSIDVDSLMRSVSRVFKFIDM--------PTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIW 1204

  Fly  1044 PKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRLSYNDGAI 1108
            |..|::..|||:.:|....|:  :|:.:||:|.|.::||::||||:|||:|::|..||...:|.|
Human  1205 PSGGQMTVKDLTAKYTEGGNA--ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEI 1267

  Fly  1109 LIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELP 1173
            .||.:..:.|.|...|....:|||:..:||||.|.||||:||:.|.::||..::|.|:..|.:.|
Human  1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFP 1332

  Fly  1174 SGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTV 1238
            ..|..::.:||...|.|.:||:||||::|.:.:||::||.:|::||.|..:|:.|::..|.||||
Human  1333 GKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTV 1397

  Fly  1239 LTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTGKAS-FDH 1294
            :...||:..:::..:.||::...|.::.|..:||  ::..:|...:..:.:.. |.|
Human  1398 ILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLL--NERSLFRQAISPSDRVKLFPH 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	407/1463 (28%)
		ABC_membrane	112..364	CDD:294371	81/252 (32%)
		ABCC_MRP_domain1	434..632	CDD:213217	81/216 (38%)
		ABC_membrane	736..955	CDD:294371	64/237 (27%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	84/220 (38%)
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	411/1487 (28%)
		ABC_membrane	85..303	CDD:279056	74/219 (34%)
		ABCC_CFTR1	389..670	CDD:213258	94/295 (32%)
		CFTR_R	639..849	CDD:291094	22/209 (11%)
		Disordered R region. /evidence=ECO:0000269\|PubMed:10792060	654..831		20/176 (11%)
		ABC_membrane	866..1147	CDD:279056	73/281 (26%)
		ABCC_CFTR2	1208..1480	CDD:213256	90/249 (36%)
		Interaction with GORASP2. /evidence=ECO:0000269\|PubMed:21884936	1386..1480		17/69 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1452..1480		1/1 (100%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:11707463, ECO:0000269\|PubMed:16331976	1478..1480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010