DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC4

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1331	Identity:	580/1331 - (43%)
Similarity:	834/1331 - (62%)	Gaps:	69/1331 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLPPNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARC 69
            ::.|||.:.|.:.|.:.|.:..|:...|.|:.|:..|:|..|.|..:..||:|....|:.||.|.
Human     7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71

  Fly    70 RRKGDSGRKPSVLRVIGRVFGWR--LIMSGITIAALELGTRATVPLLLAGLISEFSEHGNGHSY- 131
            .   :..:|||:.|.|.:.: |:  |::...|:  :|...:...|:.|..:|:.|..:....|.
Human    72 E---NDAQKPSLTRAIIKCY-WKSYLVLGIFTL--IEESAKVIQPIFLGKIINYFENYDPMDSVA 130

  Fly   132 --NAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSAIYRKALRLSRTSLGGTTTGQVV 194
              .|..||.:|..|.|...:|.|.|...:....|::|||:...|||||||||..::|.|||||:|
Human   131 LNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIV 195

  Fly   195 NLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSK 259
            ||||||:|:||:..:..||||.|||:.:..:..|:.:||::...|:::|::.||||:...::.|.
Human   196 NLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSS 260

  Fly   260 LRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEI 324
            ||.:||..||.|:|.|||:|:||::||||.||:.|..||..:|:.|:|.|.:.:.|||:.|:...
Human   261 LRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFF 325

  Fly   325 TLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLVSMRRITNFM 389
            :..:|.:||:...:||.|..:||.|.|.....|..:|.||:.||||.:.:.:|.:||:|||..|:
Human   326 SASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFL 390

  Fly   390 MREEANVIDMSERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNN 454
            :.:|     :|:|..:...:                 ||:   :|.::...|.|.:......|..
Human   391 LLDE-----ISQRNRQLPSD-----------------GKK---MVHVQDFTAFWDKASETPTLQG 430

  Fly   455 VNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILF 519
            ::.::|.|:|:||:||||:|||||:.|:||||.|..|.|.|.|:.:|.||:||:|:.::|.||||
Human   431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILF 495

  Fly   520 GLPMDKQRYRTVLKRCALERDLELLH-GDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDD 583
            |...:|:||..|:|.|||::||:||. ||.|::|:||.:|||||:||:.||||||:.||:|||||
Human   496 GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDD 560

  Fly   584 PLSAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQ 648
            ||||||..|.||||:.|:...|.:::.||||||||:|:.|..|:|:..|.:...|||.|.||||.
Human   561 PLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGI 625

  Fly   649 DFAQLL----VESTQNSGGGDEIITSPNLSRQSSALSTKSSNGS--SSSLESMVEKEKPKPSAVS 707
            ||..||    .||.|....|...:.:...| :||..|.:||..|  ..:|||...:..|   ...
Human   626 DFGSLLKKDNEESEQPPVPGTPTLRNRTFS-ESSVWSQQSSRPSLKDGALESQDTENVP---VTL 686

  Fly   708 SQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTAS------- 765
            |:|:||.|::|...||.||.||...:||:.||:|....|:.....|::||||....:.
Human   687 SEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNG 751

  Fly   766 ----SSTLDIYYFTAINVGLVICALL----RTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTN 822
                :..||:.::..|..||.:..:|    |:||.|.:.::||..|||.||:.:.:..:.||..|
Human   752 GGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRN 816

  Fly   823 PSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDF 887
            |.|||||||:.|:|.:|:::|...||.||..|.:.|::.|.....||..|....:.:.|.:.|.:
Human   817 PIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRY 881

  Fly   888 YLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSR 952
            :|:|||||||||:..|||::||.|::|.||.||||..|::.....:|.:|||||..::.|::|||
Human   882 FLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSR 946

  Fly   953 AFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVE 1017
            .|...||..|..:||.|...:.......:|||:|||::.||.:.||.||.:|||||:||.|.|||
Human   947 WFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVE 1011

  Fly  1018 RVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVG 1082
            ||:||.||:.|..:.  .:|:||.:||.||.::..:::..|.|  ..|.|||.|:..|:..||||
Human  1012 RVIEYTDLEKEAPWE--YQKRPPPAWPHEGVIIFDNVNFMYSP--GGPLVLKHLTALIKSQEKVG 1072

  Fly  1083 IVGRTGAGKSSLINALFRLSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDP 1147
            |||||||||||||:||||||..:|.|.||.:.|.:|||||||.|:||||||||||:||||.||||
Human  1073 IVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDP 1137

  Fly  1148 FEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDE 1212
            |.::.|::||.||::|.|||.|.:||..:.:.::|.|:||||||||||||||||||:|:||::||
Human  1138 FNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDE 1202

  Fly  1213 ATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKA 1277
            |||||||:||.|||..||.||..|||||||||||||:||||::|:|:|.:.|:..||.|| .:|.
Human  1203 ATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL-QNKE 1266

  Fly  1278 KVFHGMVMQTGKASFDHLLKVAENT--KQNH 1306
            .:|:.||.|.|||....|.:.|:..  |:|:
Human  1267 SLFYKMVQQLGKAEAAALTETAKQVYFKRNY 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	567/1294 (44%)
		ABC_membrane	112..364	CDD:294371	103/254 (41%)
		ABCC_MRP_domain1	434..632	CDD:213217	103/198 (52%)
		ABC_membrane	736..955	CDD:294371	87/233 (37%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	138/220 (63%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	568/1297 (44%)
		ABC_membrane	96..365	CDD:294371	105/270 (39%)
		ABCC_MRP_domain1	410..610	CDD:213217	103/199 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		10/33 (30%)
		ABC_membrane	718..991	CDD:279056	101/272 (37%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	138/220 (63%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1102	1.000	Inparanoid score	I233
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm40263
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.070