DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abcc9

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_031754288.1	Gene:	abcc9 / 101733439	XenbaseID:	XB-GENE-6074535	Length:	1577	Species:	Xenopus tropicalis

Alignment Length:	1434	Identity:	420/1434 - (29%)
Similarity:	699/1434 - (48%)	Gaps:	220/1434 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPNPRESAGI---------LSSLMFCFALPILFKGRKQTLQPTDL------------------YK 44
            ||...:..|:         ||...:.:..|::....|   :|.||                  .|
Frog   204 PPEDLQDLGVRFLQPFVNLLSKATYWWMNPLIISAHK---RPIDLKTIGKLPIAMRALTNYLSLK 265

  Fly    45 TLNEHEAASLGDEFFQGWEDEVARCRRKGDSGRKPSVLRVIGRVFGWRLIMSGI--TIAALELGT 107
            |..|.:...|.|.                 ..:.||:.:.|.|.||..:::|..  .:|.| ||.
Frog   266 TAYEEQKKKLVDR-----------------PHKDPSIWKAIYRAFGRPILLSSTFRYLADL-LGF 312

  Fly   108 RATVPLLLAGLISEFSEHGNGHS---------------------YNAQIYAVLL-IACILASVLL 150
            ..  ||.::|::........|.:                     .|..:.|||| :|.||....|
Frog   313 AG--PLCISGIVQLLDSRNKGPTDQDFPKTNFSSVYFLSSKGLIENYYVLAVLLFLALILQRTFL 375

  Fly   151 THPYMMGMMHLAMKMRVAVSSAIYRKALRLSRT--SLGGTTTGQVVNLLSNDLNRFDRCLIHFHF 213
            ...|.: .:...:.:|.|:.|.||.|.||||.:  |:|..|.||:.||::.:.|:    |:.|.|
Frog   376 QASYYV-TIETGINLRGALLSMIYNKILRLSTSNMSMGEMTLGQINNLVAIETNQ----LMWFLF 435

  Fly   214 ----LWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRM 274
                ||..|:::::....|::.:|:::..|.:::||..|:|.:::...::::..|...:.:|::.
Frog   436 LCPNLWAMPIQIIMGVILLHKLVGVSALVGAAVIVLLAPMQYFIATKLAEVQKNTLDYSTERLKK 500

  Fly   275 MNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFV 339
            .|||:.||:::|:|.||..|...:.:.|..|:.|::...|...:.:.....:...|:..:.:...
Frog   501 TNEILKGIKLLKLYAWENIFCNSVEETRIKELKSLKTFALHTSLSIFMNAAIPIAAVLATFVTHA 565

  Fly   340 -LGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFA-ELLVSMRRITNFMMREEANVIDMSER 402
             :....||...||...:.::||  ....|..|.:.:|| :.|||::::..|...:|.
Frog   566 YVSSSHLTPANAFASLSLFHIL--VTPLFLLSTVVRFAVKALVSVQKLNEFFTSDEI-------- 620

  Fly   403 RDEKAEEEQHLLKEVEKRSYPVGI------GKEP-------------------DTLVEIKALRA- 441
            |::.....:..|.....|.:| ||      .|:|                   ||  |..||:.
Frog   621 REDGFRNGETTLPFESCRKHP-GIHSRAFNRKQPLRYQMDKYDQAPKRQVRTSDT--EDAALKVC 682

  Fly   442 ----RWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGEL---------------- 486
                .||...  ..|.|:::.:..|:|..::|.||.|||||:.|||||:
Frog   683 GGFFSWGTGL--ATLANIDIQIPTGELTMIVGQVGCGKSSLLLAILGEMQTLEGRVVWNKFGSQR 745

  Fly   487 --PPES--------GSVQVSGKYS--YASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALER 539
              |..|        ||.:...::|  ||.|:|||.||::.:||.||.|.:||||:.|...|:|:.
Frog   746 RAPGSSANGWDSACGSERSKNRHSVAYAGQKPWLLNATLEENITFGSPFNKQRYKAVTDACSLQP 810

  Fly   540 DLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRG 603
            |::|| .||.|.:||||.:||||||.|||:|||:|:..::..||||.||:|.|:..||..|.:..
Frog   811 DIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILK 875

  Fly   604 FL--GKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEM-------------LKSGQDFAQL 653
            ||  .|:.|:||||:||:|..||.|:.|..|.|...||.:::             |.:.||
Frog   876 FLREDKRTVVLVTHKLQYLPHADWIIAMKDGSVLREGTLKDIQNNDNELYEHWKTLMNRQD---- 936

  Fly   654 LVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIG 718
              :..:.....|::    .:.|::...:..|......:.|...|:|:.......|...|...:..
Frog   937 --QELEKDSDADQV----TMERKTLRRAMYSREAKVQAEEEEEEEEEEDEDETMSTAMRLRTKFP 995

  Fly   719 LSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTAS--------------SSTL 769
            .....:|..:|..:|:|:::....:...::.: .||:|:.|...|::              .|::
Frog   996 WRTCWRYLTSGGYLLLFLMIFSKLLKHSVIVA-IDYWLASWTSETSNISYAQSDNVTSASELSSI 1059

  Fly   770 DIYYFTAINV----GLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNR 830
            ..||.|..:|    |:|:| |:.:|....:.::::..||:.:.:.:....:.||.|.|.|.||||
Frog  1060 QSYYVTGFSVLSATGIVLC-LIASLTVEWMGLNAAKNLHHNLLKKIILAPIRFFDTTPLGLILNR 1123

  Fly   831 FANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDV 895
            |:.|...:|:.:|..:....:..|.....|.|:....|..::....:.:|||:.:.::...|:|:
Frog  1124 FSADTNIIDQHIPPTLESLTRSTLLCLSAIGVISYATPISMVALLPLGVAFYFIQKYFRVASKDL 1188

  Fly   896 KRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDL 960
            :.|:...:.|:..|||.|..||.||||...:.....:.....|.::..|....:.:|......|.
Frog  1189 QELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTDTNNLAYLFLSAANRWLEVRTDY 1253

  Fly   961 F--CVAYVISV--ILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLE 1021
            .  |:....:|  |.:..      ::|.:||.:|.||.:|..:.|.:|..|:||..:.:|::|..
Frog  1254 LGACIVLTAAVFSITYGL------DSGIVGLGLTYALTVTNYLNWVVRNLADLEVQIGAVKKVNS 1312

  Fly  1022 YKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGR 1086
            :.:::.|....|..::|.|:.||:.|::...||.:|||  .|...|||.|...|:|.:||||.||
Frog  1313 FLNIESECYEGSMEQQQVPEDWPQSGEIRISDLCVRYE--NNHKPVLKHLKAYIKPGQKVGICGR 1375

  Fly  1087 TGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQ 1150
            ||:|||||..|.||: ...||.|:||.:|.:.:.|:.|||::|||.|:|:||||::|:||||..:
Frog  1376 TGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLNTLRSRLSIILQDPILFSGSIRFNLDPECK 1440

  Fly  1151 YPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATA 1215
            ..|::||:.|:...||..:..||.||.::::|||.|||||||||.|||||.:|.:.||:||||||
Frog  1441 CSDERLWEGLDIAQLKNLVKALPGGLDAMVTEGGENFSVGQRQLFCLARAFVRNSSILIMDEATA 1505

  Fly  1216 NVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVF 1280
            ::|..|:.::|..:...|.|.||:|||||::||:..|..:||..|:::|..:|..|| |.:..:|
Frog  1506 SIDMATENILQKVVMTAFADRTVVTIAHRVHTILTGDVAIVMRRGNILEHDTPGNLL-AQEDSIF 1569

  Fly  1281 HGMV 1284
            ...|
Frog  1570 ASFV 1573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	416/1421 (29%)
		ABC_membrane	112..364	CDD:294371	68/280 (24%)
		ABCC_MRP_domain1	434..632	CDD:213217	96/233 (41%)
		ABC_membrane	736..955	CDD:294371	54/236 (23%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	108/221 (49%)
abcc9	XP_031754288.1	MRP_assoc_pro	222..1574	CDD:188098	417/1416 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010