DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC9

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_001364202.1	Gene:	ABCC9 / 10060	HGNCID:	60	Length:	1549	Species:	Homo sapiens

Alignment Length:	1378	Identity:	419/1378 - (30%)
Similarity:	697/1378 - (50%)	Gaps:	136/1378 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPNPRESAGI---------LSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGW 62
            ||...:..|:         ||...:.:...::....|   :|.|| |.:.:...|......:...
Human   204 PPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK---KPIDL-KAIGKLPIAMRAVTNYVCL 264

  Fly    63 EDEVARCRRK--GDSGRKPSVLRVIGRVFGWRLIMSGI--TIAALELGTRATVPLLLAGLISEFS 123
            :|.....::|  ....|.||:...:.|.||..:::|..  .:|.| ||...  ||.::|::...:
Human   265 KDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL-LGFAG--PLCISGIVQRVN 326

  Fly   124 EHGNGHS---------------YNAQIYAVLL-IACILASVLLTHPYMMGMMHLAMKMRVAVSSA 172
            |..||.:               .||.:.|||| :|.||....|...|.: .:...:.:|.|:.:.
Human   327 ETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYV-TIETGINLRGALLAM 390

  Fly   173 IYRKALRLSRT--SLGGTTTGQVVNLLSNDLNRFDRCLIHFHF----LWLGPLELLIASYFLYEQ 231
            ||.|.||||.:  |:|..|.||:.||::.:.|:    |:.|.|    ||..|:::::....||..
Human   391 IYNKILRLSTSNLSMGEMTLGQINNLVAIETNQ----LMWFLFLCPNLWAMPVQIIMGVILLYNL 451

  Fly   232 IGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGK 296
            :|.::..|.:::||..|:|.:::...::.:..|...:.:|::..|||:.||:::|:|.||..|.|
Human   452 LGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCK 516

  Fly   297 LIGQMRRSEMSSIRQMNLLRGILLSFEITLGRIAIFVSLLGFV-LGGGELTAERAFCVTAFYNIL 360
            .:.:.|..|:||::...|...:.:.....:...|:..:.:... ..|..|....||...:.::||
Human   517 SVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHIL 581

  Fly   361 RRTVSKFFPSGMSQFA-ELLVSMRRITNFMMREEANVIDMSERRDE------------------- 405
              ....|..|.:.:|| :.::|::::..|::.:|  :.|.|.|..|
Human   582 --VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDE--IGDDSWRTGESSLPFESCKKHTGVQPKTI 642

  Fly   406 -KAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIG 469
             :.:..::.|...|:.:..:...:..|..:::......||...  ..|:|:::.:..|||..::|
Human   643 NRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGL--ATLSNIDIRIPTGQLTMIVG 705

  Fly   470 PVGSGKSSLIQAILGELPPESGSVQVS---------------GKYS--YASQEPWLFNASVRDNI 517
            .||.|||||:.|||||:....|.|..|               .:||  ||:|:|||.||:|.:||
Human   706 QVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENI 770

  Fly   518 LFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLL 581
            .||.|.:||||:.|...|:|:.|::|| .||.|.:||||.:||||||.|||:|||:|:..::..|
Human   771 TFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFL 835

  Fly   582 DDPLSAVDTHVGRHLFDECMRGFL--GKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEM- 643
            |||.||:|.|:..||..|.:..||  .|:.::||||:||:|..||.|:.|..|.|...||.:::
Human   836 DDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900

  Fly   644 ------------LKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMV 696
                        |.:.||     .|..::.......:....|.|...:...|:........|...
Human   901 TKDVELYEHWKTLMNRQD-----QELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960

  Fly   697 EKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGVLVFVVLIMLCIGTQILASGGDYFLSYW-- 759
            |.|....|.|....::...:   :.::.....|..:|:.::...|...:.|:|.  ||:|:.|
Human   961 EDEDDNMSTVMRLRTKMPWK---TCWRYLTSGGFFLLILMIFSKLLKHSVIVAI--DYWLATWTS 1020

  Fly   760 ---VKNTASSSTLDIYYFTAINV----GLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALY 817
               :.||..:.  ..||....::    |:.:| |:.:|....:.:.::..||:.:...:....:.
Human  1021 EYSINNTGKAD--QTYYVAGFSILCGAGIFLC-LVTSLTVEWMGLTAAKNLHHNLLNKIILGPIR 1082

  Fly   818 FFHTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICVLCVTNPWYLINTFAMMLAFY 882
            ||.|.|.|.|||||:.|...:|:.:|..:....:..|.....|.::....|.:|:....:.:|||
Human  1083 FFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFY 1147

  Fly   883 YWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTF 947
            :.:.::...|:|::.|:...:.|:..|||.|..||.||||...:.....:.....|.::..|...
Human  1148 FIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFL 1212

  Fly   948 VSTSRAFGYYLDLFCVAYVISVILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENA 1012
            .:.:|......|......|::..:.:....  .|:|.:||.:..||.:|..:.|.:|..|:||..
Human  1213 SAANRWLEVRTDYLGACIVLTASIASISGS--SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQ 1275

  Fly  1013 MTSVERVLEYKDLDPEGDFNSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQP 1077
            |.:|::|..:..::.|....:....|.|:.||:||::...||.:|||  .|...|||.:...|:|
Human  1276 MGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYE--NNLKPVLKHVKAYIKP 1338

  Fly  1078 MEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTM 1141
            .:||||.||||:|||||..|.||: ...||.|:||.:|.:.:.||.|||::|||.|:|:||||::
Human  1339 GQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSI 1403

  Fly  1142 RYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENR 1206
            |:||||..:..||:||:|||...||..:..||.||.::::|||.|||||||||.|||||.:|::.
Human  1404 RFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSS 1468

  Fly  1207 ILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYEL 1271
            ||:||||||::|..|:.::|..:...|.|.||:|||||::||:.:|.|:||..|:::|:.:| |.
Human  1469 ILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTP-ES 1532

  Fly  1272 LTASKAKVFHGMV 1284
            |.|.:..||...|
Human  1533 LLAQENGVFASFV 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	414/1365 (30%)
		ABC_membrane	112..364	CDD:294371	73/274 (27%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/217 (43%)
		ABC_membrane	736..955	CDD:294371	54/227 (24%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	112/221 (51%)
ABCC9	NP_001364202.1	MRP_assoc_pro	222..1546	CDD:188098	416/1360 (31%)
ABCC9	NP_001364202.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..967		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810