DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and ABCC5

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	NP_005679.2	Gene:	ABCC5 / 10057	HGNCID:	56	Length:	1437	Species:	Homo sapiens

Alignment Length:	1390	Identity:	460/1390 - (33%)
Similarity:	745/1390 - (53%)	Gaps:	178/1390 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGILSSLMFCFALPIL-FKGRKQTLQPTDLYKTLNEHEAASLGDEFFQG-WEDEVARCRR 71
            :|.::||:.|.:.|.:...:. ...:|..|...|:: :|::||::.:.....:. |::|:
Human    99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW-SLSKHESSDVNCRRLERLWQEEL----- 157

  Fly    72 KGDSGRKPSVLRVIGRVF-GWRLIMSGITIAALELGTRATVPLLLAG------LISEFSEHGNGH 129
             .:.|...:.||.:..:| ..|||:|.:.:...:          |||      ::....|:....
Human   158 -NEVGPDAASLRRVVWIFCRTRLILSIVCLMITQ----------LAGFSGPAFMVKHLLEYTQAT 211

  Fly   130 SYNAQIYAVLLIACILA-------SVLLTHP--YMMGMMHLAMKMRVAVSSAIYRKALRLSRTSL 185
            ..|.| |::||:..:|.       |:.||..  |..|     :::|.|:.:..::|.|:|.  ::
Human   212 ESNLQ-YSLLLVLGLLLTEIVRSWSLALTWALNYRTG-----VRLRGAILTMAFKKILKLK--NI 268

  Fly   186 GGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQ 250
            ...:.|:::|:.|||..|..........|..||:..::...:....:|...|.|.::.:|:.|..
Human   269 KEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM 333

  Fly   251 TYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLL 315
            .:.||:|:..|.:....||:||:.|||:::.|:.||||.|.:.|.:.:.::|..|...:.:....
Human   334 MFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYF 398

  Fly   316 RGILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLV 380
            :.|.:.....:..||..|:....:..|.:|||.:||.|...:|.:...: |..|..:...:|..|
Human   399 QSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFAL-KVTPFSVKSLSEASV 462

  Fly   381 SMRRITNFMMREEANVI--------------------DMSE-------------RRDEK------ 406
            ::.|..:..:.||.::|                    |.|.             ::|::
Human   463 AVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKK 527

  Fly   407 ---------------AEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVN 456
                           ||::.|||.:.::|..|   .:|....:.:..||.:       ..|::::
Human   528 EKVRQLQRTEHQAVLAEQKGHLLLDSDERPSP---EEEEGKHIHLGHLRLQ-------RTLHSID 582

  Fly   457 MSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGL 521
            :.::.|:||.:.|.|||||:|||.||||::....||:.:||.::|.:|:.|:.||::|||||||.
Human   583 LEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGK 647

  Fly   522 PMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPL 585
            ..|::||.:||..|.|..||.:| ..|.|.:|||||:||||||.||.||||:|....:|:|||||
Human   648 EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPL 712

  Fly   586 SAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDF 650
            ||:|.|||.|:|:..:|..|..:.|:.||||||:|.|.|.::.|.:|.::..||:||::....|:
Human   713 SALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777

  Fly   651 AQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKE---KPKPSAVSSQESR 712
            |.:.    .|...|:......|..:::|....||.:....:  ..|:||   ||:...:...|.:
Human   778 ATIF----NNLLLGETPPVEINSKKETSGSQKKSQDKGPKT--GSVKKEKAVKPEEGQLVQLEEK 836

  Fly   713 SGGQIGLSMYKKYFGAGCGVLVFVV---LIMLCIGTQILASGGDYFLSYWVKNTASSSTL----- 769
            ..|.:..|:|..|..|..|.|.|:|   |.||.:|:...::   ::||||:|..:.::|:
Human   837 GQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFST---WWLSYWIKQGSGNTTVTRGNE 898

  Fly   770 -----------DIYYFTAI----NVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFF 819
                       .:.|:.:|    ...::|...:|.::|...|:.:|:.||:.:|:.:.|:.:.||
Human   899 TSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFF 963

  Fly   820 HTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICV-LCV-----TNPWYLINTFAMM 878
            .|.|:|||||||:.|:.:||..:|      .|..:.:..:|.| .||     ..||:|:....::
Human   964 DTTPTGRILNRFSKDMDEVDVRLP------FQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLV 1022

  Fly   879 LAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSG 943
            :.|...........|::|||:.:.:||..||.::::.||.||.|....|..:.:|....|.:.:.
Human  1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAP 1087

  Fly   944 YYTFVSTSRAFGYYLDLFCVAYVIS-----VILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGM 1003
            ::.|....|.....|||..:|.:.:     |::|... ||.:    .||||:.|:.:||:.|:.:
Human  1088 FFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQI-PPAY----AGLAISYAVQLTGLFQFTV 1147

  Fly  1004 RQSAELENAMTSVERVLEY-KDLDPEGDFNSPA---EKQPPKSWPKEGKLVTKDLSLRYEPDTNS 1064
            |.::|.|...|||||:..| |.|..|    :||   .|.|...||:||::..::..:||.  .|.
Human  1148 RLASETEARFTSVERINHYIKTLSLE----APARIKNKAPSPDWPQEGEVTFENAEMRYR--ENL 1206

  Fly  1065 PCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKIS 1128
            |.|||.:||||:|.||:|||||||:|||||..||||| ..:.|.|.||.:..:||||.|||||:|
Human  1207 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLS 1271

  Fly  1129 IIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQ 1193
            ||||||||||||:|.|||||.||.:|::|.|||..|:||.|::||..|:|.:.|.|.|||||:||
Human  1272 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1336

  Fly  1194 LVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMD 1258
            |:|:|||:||..:||::|||||.:|.:||.|||.|||..|.|||:|||||||:|::.||:::|:.
Human  1337 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1401

  Fly  1259 AGHVVEFGSPYELLTASKAKVFHGM 1283
            .|.||||.:|..||:...:: |:.|
Human  1402 QGQVVEFDTPSVLLSNDSSR-FYAM 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	457/1378 (33%)
		ABC_membrane	112..364	CDD:294371	66/266 (25%)
		ABCC_MRP_domain1	434..632	CDD:213217	92/198 (46%)
		ABC_membrane	736..955	CDD:294371	64/247 (26%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	131/221 (59%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	460/1389 (33%)
		ABC_membrane	<271..447	CDD:294371	46/175 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..538		2/36 (6%)
		ABCC_MRP_domain1	577..759	CDD:213217	90/181 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..827		9/34 (26%)
		ABC_membrane	863..1143	CDD:294371	78/293 (27%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	131/221 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1827
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.770