Protein Alignment CG31793 and ABCC5

DIOPT Version :10

• Sequence 1: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Sequence 2: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 1390
• Identity: 460/1390 - (33%)
• Similarity: 745/1390 - (53%)
• Gaps: 178/1390 - (12%)

  Fly     9 NPRESAGILSSLMFCFALPIL-FKGRKQTLQPTDLYKTLNEHEAASLGDEFFQG-WEDEVARCRR 71
            :|.::||:.|.:.|.:...:. ...:|..|...|:: :|::||::.:.....:. |::|:
Human    99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW-SLSKHESSDVNCRRLERLWQEEL----- 157

  Fly    72 KGDSGRKPSVLRVIGRVF-GWRLIMSGITIAALELGTRATVPLLLAG------LISEFSEHGNGH 129
             .:.|...:.||.:..:| ..|||:|.:.:...:          |||      ::....|:....
Human   158 -NEVGPDAASLRRVVWIFCRTRLILSIVCLMITQ----------LAGFSGPAFMVKHLLEYTQAT 211

  Fly   130 SYNAQIYAVLLIACILA-------SVLLTHP--YMMGMMHLAMKMRVAVSSAIYRKALRLSRTSL 185
            ..|.| |::||:..:|.       |:.||..  |..|     :::|.|:.:..::|.|:|.  ::
Human   212 ESNLQ-YSLLLVLGLLLTEIVRSWSLALTWALNYRTG-----VRLRGAILTMAFKKILKLK--NI 268

  Fly   186 GGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQ 250
            ...:.|:::|:.|||..|..........|..||:..::...:....:|...|.|.::.:|:.|..
Human   269 KEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM 333

  Fly   251 TYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLL 315
            .:.||:|:..|.:....||:||:.|||:::.|:.||||.|.:.|.:.:.::|..|...:.:....
Human   334 MFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYF 398

  Fly   316 RGILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLV 380
            :.|.:.....:..||..|:....:..|.:|||.:||.|...:|.:...: |..|..:...:|..|
Human   399 QSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFAL-KVTPFSVKSLSEASV 462

  Fly   381 SMRRITNFMMREEANVI--------------------DMSE-------------RRDEK------ 406
            ::.|..:..:.||.::|                    |.|.             ::|::
Human   463 AVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKK 527

  Fly   407 ---------------AEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVN 456
                           ||::.|||.:.::|..|   .:|....:.:..||.:       ..|::::
Human   528 EKVRQLQRTEHQAVLAEQKGHLLLDSDERPSP---EEEEGKHIHLGHLRLQ-------RTLHSID 582

  Fly   457 MSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGL 521
            :.::.|:||.:.|.|||||:|||.||||::....||:.:||.::|.:|:.|:.||::|||||||.
Human   583 LEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGK 647

  Fly   522 PMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPL 585
            ..|::||.:||..|.|..||.:| ..|.|.:|||||:||||||.||.||||:|....:|:|||||
Human   648 EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPL 712

  Fly   586 SAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDF 650
            ||:|.|||.|:|:..:|..|..:.|:.||||||:|.|.|.::.|.:|.::..||:||::....|:
Human   713 SALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777

  Fly   651 AQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKE---KPKPSAVSSQESR 712
            |.:.    .|...|:......|..:::|....||.:....:  ..|:||   ||:...:...|.:
Human   778 ATIF----NNLLLGETPPVEINSKKETSGSQKKSQDKGPKT--GSVKKEKAVKPEEGQLVQLEEK 836

  Fly   713 SGGQIGLSMYKKYFGAGCGVLVFVV---LIMLCIGTQILASGGDYFLSYWVKNTASSSTL----- 769
            ..|.:..|:|..|..|..|.|.|:|   |.||.:|:...::   ::||||:|..:.::|:
Human   837 GQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFST---WWLSYWIKQGSGNTTVTRGNE 898

  Fly   770 -----------DIYYFTAI----NVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFF 819
                       .:.|:.:|    ...::|...:|.::|...|:.:|:.||:.:|:.:.|:.:.||
Human   899 TSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFF 963

  Fly   820 HTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICV-LCV-----TNPWYLINTFAMM 878
            .|.|:|||||||:.|:.:||..:|      .|..:.:..:|.| .||     ..||:|:....::
Human   964 DTTPTGRILNRFSKDMDEVDVRLP------FQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLV 1022

  Fly   879 LAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSG 943
            :.|...........|::|||:.:.:||..||.::::.||.||.|....|..:.:|....|.:.:.
Human  1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAP 1087

  Fly   944 YYTFVSTSRAFGYYLDLFCVAYVIS-----VILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGM 1003
            ::.|....|.....|||..:|.:.:     |::|... ||.:    .||||:.|:.:||:.|:.:
Human  1088 FFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQI-PPAY----AGLAISYAVQLTGLFQFTV 1147

  Fly  1004 RQSAELENAMTSVERVLEY-KDLDPEGDFNSPA---EKQPPKSWPKEGKLVTKDLSLRYEPDTNS 1064
            |.::|.|...|||||:..| |.|..|    :||   .|.|...||:||::..::..:||.  .|.
Human  1148 RLASETEARFTSVERINHYIKTLSLE----APARIKNKAPSPDWPQEGEVTFENAEMRYR--ENL 1206

  Fly  1065 PCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKIS 1128
            |.|||.:||||:|.||:|||||||:|||||..||||| ..:.|.|.||.:..:||||.|||||:|
Human  1207 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLS 1271

  Fly  1129 IIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQ 1193
            ||||||||||||:|.|||||.||.:|::|.|||..|:||.|::||..|:|.:.|.|.|||||:||
Human  1272 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1336

  Fly  1194 LVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMD 1258
            |:|:|||:||..:||::|||||.:|.:||.|||.|||..|.|||:|||||||:|::.||:::|:.
Human  1337 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1401

  Fly  1259 AGHVVEFGSPYELLTASKAKVFHGM 1283
            .|.||||.:|..||:...:: |:.|
Human  1402 QGQVVEFDTPSVLLSNDSSR-FYAM 1425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	460/1389 (33%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	459/1387 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		2/36 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		9/34 (26%)