DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31793 and tap2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_002942649.3	Gene:	tap2 / 100489020	XenbaseID:	XB-GENE-481680	Length:	728	Species:	Xenopus tropicalis

Alignment Length:	683	Identity:	154/683 - (22%)
Similarity:	295/683 - (43%)	Gaps:	156/683 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   668 ITSPNLSRQSSALSTKSSNGSSSSLESMVEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAGCGV 732
            :.|||:      |..||:.|.::|      |::.:.:.:...:......:.|          ||.
Frog   129 LVSPNI------LPNKSAEGEANS------KKRERENFIRLLKYSIPDWLPL----------CGA 171

  Fly   733 LVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSSTLDIY--------------YFTAINVGLVI 783
            .||:.|.::          |:.|:.|::     ...:||.              :....::...|
Frog   172 FVFLTLALI----------GEMFIPYYM-----GRVIDILSTNYNEREFLRAMSFMAMFSITSSI 221

  Fly   784 CALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMPA---- 844
            .|..|..||.......:..|...:|:.:.:..:.||....||.|.:|..||..:|...:.|
Frog   222 FAGSRGGLFMFSLARLTQRLRLLLFRSVIKQEIAFFEATKSGDITSRLTNDTARVSRSIAANVNI 286

  Fly   845 ---VMLDCIQIF---------LTLTGIICVLCVTNP--WYLINTFAMMLAFYYWRDFYLKTSRDV 895
               :::.|:.::         |||     :..:::|  |.:...:.     ||.:|.       |
Frog   287 TLRMLVKCVGVYSFMFSLSWQLTL-----LTFISSPLTWIIQKVYN-----YYHQDL-------V 334

  Fly   896 KRL-EAVARSPMYSHFSATLV-GLPTIRAMGAQQTLIGQYDN-YQDLHSSGYYTFVSTSRAFGYY 957
            ||: :::|||   |..:..:: .:..:.:..|::....:|:| .|:.|      .:.|.|
Frog   335 KRVQDSIARS---SELAKEIIESVRNVYSFAAEEEEAKRYENSLQETH------VLQTRR----- 385

  Fly   958 LDLFCVAYVISVILHNFFNPPLHNAGQIGLAIT-----QALGMTGMVQWGMRQS----------- 1006
             |.....|::...|.|           :|..:|     |.|..:|.:..|...|
Frog   386 -DFVTALYLLVTRLVN-----------LGTQVTMLYYGQILIRSGFISSGKMVSFILYQMESDSY 438

  Fly  1007 --------AELENAMTSVERVLEYKDLDPEGDFNS---PAEKQPPKSWPKEGKLVTKDLSLRYEP 1060
                    :|:.:|..:.|:|.:|.|.:|:...:.   |...|        |:....:::..| |
Frog   439 IRTLVHMLSEITHAAGAAEKVFQYLDREPQVSASGCLCPGTLQ--------GRFEFSNVTFSY-P 494

  Fly  1061 DTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLR 1124
            .......|:.:|||:.|.....:||.:|.||::.::.|.|. ....|.||:|.....:.....|.
Frog   495 SRPEILALQNVSFTLPPGSVTALVGPSGGGKTTCVSLLERFYEPQGGNILLDGKPLKEYKHEYLH 559

  Fly  1125 SKISIIPQEPVLFSGTMRYNLDPFEQY--PDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNF 1187
            ||::::.||||||:|::|.|:. :..|  |::||..|......::.|..:.....:.:...|...
Frog   560 SKVALVAQEPVLFAGSVRENIS-YGLYNIPEEKLKAAARKAKAEDFIEGMEKAYDTDVGNSGAQL 623

  Fly  1188 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSD 1252
            |.||:|.|.||||:.|:.::|::|||::.:|.:|:..||.:::: .:|.::|.|||||.|:..:|
Frog   624 SAGQKQRVALARALARKPKLLILDEASSCLDAETEHEIQKSLQS-IEDLSLLIIAHRLRTVQKAD 687

  Fly  1253 KVLVMDAGHVVEFGSPYELLTASKAKVFHGMVM 1285
            ::||::||::||.|:..:|:...:..:...:|:
Frog   688 QILVLEAGNLVEQGTHEKLVQKXRECITVSLVV 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	153/669 (23%)
		ABC_membrane	112..364	CDD:294371
		ABCC_MRP_domain1	434..632	CDD:213217
		ABC_membrane	736..955	CDD:294371	46/253 (18%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	72/223 (32%)
tap2	XP_002942649.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000