DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abcc8b

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_021323602.1	Gene:	abcc8b / 100329706	ZFINID:	ZDB-GENE-120215-45	Length:	1607	Species:	Danio rerio

Alignment Length:	1424	Identity:	428/1424 - (30%)
Similarity:	704/1424 - (49%)	Gaps:	187/1424 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPNPRESAGILSSLMFCFALPILFKGRKQTL------------QPTDLYKTLNEHEAASLGDEFF 59
            ||:..:..|:.      |..|.:....|.|.            :|.|| ||:.:...:......|
Zfish   221 PPDDLQDLGVR------FLQPFVNLLSKSTYWWMNTFITSAHQRPIDL-KTIGKLPKSMRALSNF 278

  Fly    60 QGWEDEVARCRRKGDSGRKPSVLRVIGRVFGWRLIMSGITIAAL----------ELGTRATVPLL 114
            |       :.|:..||..:...:.:.|..:.||.:........|          .||...  ||.
Zfish   279 Q-------QLRKAFDSQMESGCVHLQGSGWMWRALRQAFGAPLLLSICFRFISDLLGFAG--PLC 334

  Fly   115 LAGLISEFSEHGNG----------HSYNAQIY---AVLLIACILASVLLTHPYMMGMMHLAMK-- 164
            ::|::...|...:.          |..:::::   |.:|...:..::||...::....::|::
Zfish   335 ISGILQHISRDNHTAPPPVKLLGVHFISSEVFFANAYVLAVLLFLALLLQRTFLQASYYVAIENG 399

  Fly   165 --MRVAVSSAIYRKALRL--SRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHF----LWLGPLEL 221
              :|.||.:.||.|.:||  |..|:|..||.|:.||::.|.|:    |:.|.|    ||..|:::
Zfish   400 INLRGAVQTKIYNKIMRLCTSNMSMGDMTTAQICNLVARDTNQ----LMWFFFLCPNLWAMPVQI 460

  Fly   222 LIASYFLYEQIGMASFYGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIK 286
            :|....||..:|.::..|.:::.:..|||.:::...|:.:..|...|.:|::..||::.||:::|
Zfish   461 VIGVLLLYYLLGASALIGATVITVLAPLQYFVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLK 525

  Fly   287 MYTWERPFGKLIGQMRRSEMSSIRQMNLLR--GILLSFEITLGRI-AIFV------SLLGFVLGG 342
            :|.||..|...:.:.||.|::|:|...|..  .|.::..|.:..: .|||      |...|.
Zfish   526 LYAWEHIFRSSVEETRRQELTSLRTFALYTSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFA--- 587

  Fly   343 GELTAERAFCVTAFYNILRRTVSKFF--PSGMSQFAELLVSMRRITNFMMREE------------ 393
              |:...||...:.::||   |:..|  .|.:....:.|||:::::.|:...|
Zfish   588 --LSPAVAFGSLSLFHIL---VTPLFLLSSVLHSTVKALVSVQKLSEFLSSAEIETDQDPIAQTP 647

  Fly   394 ----ANVIDM------SERRDEKAEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQH 448
                .|:..:      ::..:.|.:.:|.:.:..|::...:....:.:..:.||.:...:...|.
Zfish   648 ANNNGNIKSVYALQLQAKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNICIKIVNGYFSWTQG 712

  Fly   449 DLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSV-----------------QVS 496
            ...|.|:::.:..|||..::|.||||||||:.|.|||:...|||:                 .:|
Zfish   713 CPTLTNIDIKVPFGQLTMIVGQVGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMS 777

  Fly   497 GKYS--------YASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELL-HGDGTIVG 552
            |:.|        ||||.|||.||:|.:||||....:.:||:.|::.|.|..|::.| .||.|::|
Zfish   778 GRQSFTRRGSVAYASQRPWLLNATVEENILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIG 842

  Fly   553 ER----GASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECMRGFL--GKQLVI 611
            ||    |..||||||.||.:|||:|::.:|..||||.||:|.|:..||..|.:..||  .|:.|:
Zfish   843 ERVRHLGIILSGGQRQRISVARALYQQTNVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVV 907

  Fly   612 LVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQ 676
            ||||:||:|..||.|:.|..|.|...||    ||..|.....|.|..:......:...|..|.|:
Zfish   908 LVTHKLQYLPHADWIIAMRDGTVQTQGT----LKDIQCAEPELFEQWRTLMNRQDKENSTELKRK 968

  Fly   677 SSALSTKSSNGSSSSLE----SMVEKEKPKPSAVSSQESRSGGQ------IGLSMYKKYFGAGCG 731
            |...:...|..:.::.:    :.|...:.|.|:.|:.|...|.:      |..|.:..|..| .|
Zfish   969 SFRRAMMYSRDTVATDDEDEVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFATYLKA-AG 1032

  Fly   732 VLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSS----------TLDIYYFTA--INVGLVIC 784
            :.:..:||:..:....|....|::|::|..:..::.          |.|..:..:  :.|..::|
Zfish  1033 LFLLPLLIVSQLAKHSLMVAIDFWLAHWTSDVIAAQSESAERNCTFTKDCVFSHSWYLQVFCLLC 1097

  Fly   785 AL-----LRTLLFFNIT-MHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMP 843
            ||     |.|.|....| :..:.|||.::.:.:....:..|.|.|.|.|||||:.|...:|:.:|
Zfish  1098 ALGIVLCLVTSLAVEWTGLRVAKELHCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTIDQHIP 1162

  Fly   844 AVMLDCIQIFLTLTGIICVLCV-----TNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVAR 903
             |.::|    |:.:.::||..|     ..|.:||....:.:|.|:.:.::...|||:::||....
Zfish  1163 -VTMEC----LSRSTLLCVSAVGVISYVTPVFLIALLPLTVACYFIQKYFRVASRDLQQLEDSTE 1222

  Fly   904 SPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLDLFCVAYVIS 968
            .|:.||:|.|:.||.||||...:|....:...:.|.::.......:.:|.....::......|:.
Zfish  1223 MPLLSHYSQTIEGLTTIRAFRHEQRFKKKLLEHTDANNISSLFLTAANRWLEVRMEYIGALVVLI 1287

  Fly   969 VILHNFFNPPLH--NAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDF 1031
            ..:.:..|....  :||.:||.:|.||.::..:.|.:|..|::|..:..|:||.......||...
Zfish  1288 AAVASITNALYRQLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRVSGLIHTQPESYD 1352

  Fly  1032 NSPAEKQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLIN 1096
            |.....|.|..|||.|::..::||:||  |::...|||.:|..|:|.:||||.||||:||||...
Zfish  1353 NIMTPAQVPAGWPKYGEIQIQNLSVRY--DSSLKPVLKHVSAHIRPGQKVGICGRTGSGKSSFSL 1415

  Fly  1097 ALFRL-SYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKAL 1160
            ||||: ...:|.|.||.:|.:.:.|..||||.|||.|:|:|||||:|:||||..:..|:.||:||
Zfish  1416 ALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDPERKATDEMLWEAL 1480

  Fly  1161 EDVHLKEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALI 1225
            |...|...:..||.||.::::|||.|||.|||||.|||||.:|::.||:||||||::|..|::::
Zfish  1481 EIAQLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATESIL 1545

  Fly  1226 QATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMV 1284
            |..:...|.|.||:|||||::||:.||.|:||..|.::|:..| ::|...|..||...|
Zfish  1546 QKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEP-DVLLEQKDSVFSAFV 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	423/1411 (30%)
		ABC_membrane	112..364	CDD:294371	73/283 (26%)
		ABCC_MRP_domain1	434..632	CDD:213217	94/229 (41%)
		ABC_membrane	736..955	CDD:294371	61/241 (25%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	110/221 (50%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	421/1395 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810