DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31793 and abcc6b.2

DIOPT Version :9

Sequence 1:	NP_609930.4	Gene:	CG31793 / 326161	FlyBaseID:	FBgn0051793	Length:	1307	Species:	Drosophila melanogaster
Sequence 2:	XP_003198194.2	Gene:	abcc6b.2 / 100002917	ZFINID:	ZDB-GENE-110208-2	Length:	1502	Species:	Danio rerio

Alignment Length:	1358	Identity:	459/1358 - (33%)
Similarity:	738/1358 - (54%)	Gaps:	139/1358 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PNPRESAGILSSLMFCFALPILFKGRKQTLQPTDLYKTLNEHEAASLGDEFFQGWEDEVARCRRK 72
            |.|.|.|..||.|:|.:...::.||.:..|:..||:....|..:..:..:..:.|..:.|:.::|
Zfish   205 PCPVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQWAKLQQK 269

  Fly    73 GDS-------GRKPS-------------------VLRVIGRVFGWRLIMSGITIAALELGTRATV 111
            ..|       |.|.|                   :.|.:.::|. ...::|.....::.....::
Zfish   270 KSSLNEAQTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFS-PYFLTGTLFLVIQDALMFSI 333

  Fly   112 P----LLLAGLISEFSEHGNGHSYNAQIYAVLLIACILASVLLTHPYMMGMMHLAMKMRVAVSSA 172
            |    |||..:..|.:....|:.:   .:::.|::|:.:  |..|.||...:.:.|:::.||...
Zfish   334 PQVLSLLLGYVRDEDAPLWKGYLF---AFSLFLLSCLQS--LFNHQYMYTCLTVGMRVKTAVMGL 393

  Fly   173 IYRKALRLSRTSLGGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASF 237
            :|||:|.::..:....|.|::|||:|.|..:....:::|:.|||.|:|:.:..:||::.:|.::.
Zfish   394 VYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTL 458

  Fly   238 YGISILVLYLPLQTYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMR 302
            .||:.::|..||..:::::.|||:.......|:|:::||||:|||:::|.|.||:.|.:.:...|
Zfish   459 AGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYR 523

  Fly   303 RSEMSSIRQMNLLRGILLSFEITLGRIAIFVS---LLGFVLGG--------GELTAERAFCVTAF 356
            ..|::::::..:|..:         .||.|.|   |:.|.:.|        ..|.|::.|...|.
Zfish   524 EKELNALKKSQILYSV---------SIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMAL 579

  Fly   357 YNILRRTVSKFFPSGMSQFAELLVSMRRITNFMMREEANVIDMSERRDEKAEEEQHLLKEVEKRS 421
            .|||:..:|: .|..||...:::||::|:..|:.::|..                  |..|::..
Zfish   580 INILKAPLSQ-LPIAMSTTMQVVVSLKRLGTFLDQDELK------------------LDSVQRVP 625

  Fly   422 YPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVNMSLRRGQLVAVIGPVGSGKSSLIQAILGEL 486
            |...|..     |.|......|.::... .|..:|:.::||.||||:|.||||||||:.|:|||:
Zfish   626 YNPNIES-----VVINNGTFSWSKDSTP-CLRRINVKVQRGSLVAVVGHVGSGKSSLLSAMLGEM 684

  Fly   487 PPESGSVQVSGKYSYASQEPWLFNASVRDNILFGLPMDKQRYRTVLKRCALERDLELLHG-DGTI 550
            ..:||.:.::|...|..|:.|:.||:::||||||.......|:.||:.|||..|||:|.. |.|.
Zfish   685 EKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATE 749

  Fly   551 VGERGASLSGGQRARICLARAVYRRADVYLLDDPLSAVDTHVGRHLFDECM--RGFLGKQLVILV 613
            :||:|.:|||||:.|:.|||||||.:|:|||||||||||.|||:|:|::.:  .|.|..:..:||
Zfish   750 IGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLV 814

  Fly   614 THQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDFAQLLVESTQNSGGGDEIITSPNLSRQSS 678
            ||.|.||..||||::|..|.:...|:|.|:|.....||:|...|....   .|..|.....:..|
Zfish   815 THGLSFLPQADLILVMADGEIKEMGSYAELLSRKNAFAELKAFSVSER---KESATLKGTRKSVS 876

  Fly   679 ALSTKS-------SNGSSSSLESM-------VEKEKPKPSAVSSQESRSGGQIGLSMYKKYFGAG 729
            .||.|.       .:..|:|:::|       :.:::.:...::..:....|::.|.||.:||..
Zfish   877 FLSIKDFSTDLIRGDLGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRT- 940

  Fly   730 CGVLVFVVLIMLCIGTQILASGGDYFLSYWVKNTASSST-------LDIYYFTAINVGLVICALL 787
            .|:...:.:|.|....|:.:...:|:||.|..:...:.|       |.:|.......|:.|....
Zfish   941 IGLAFIIPIIFLYAFQQVASLAYNYWLSLWADDPVINGTQVNTDLKLGVYGALGFAQGIAIFGTT 1005

  Fly   788 RTLLFFNITMHSSTELHNTMFQGLSRTALYFFHTNPSGRILNRFANDLGQVDEVMP---AVMLDC 849
            ..:....|.  :|.:||..:...:..:.:.||.:.|||.:||||:.::..:|.::|   .:||.
Zfish  1006 VAISLGGII--ASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLG- 1067

  Fly   850 IQIFLTLTGIICVLCVTNPWYLINTFAMMLAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATL 914
             .:|..|...|.||..| |:..:....:.|.:.:.:.||:.||..::|||:|:|||:|:||:.|:
Zfish  1068 -YVFKLLEVCIIVLMAT-PFAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETV 1130

  Fly   915 VGLPTIRAMGAQQTLIGQYDNYQDLHSSGYYTFVSTSRAFGYYLD-----LFCVAYVISVILHNF 974
            .|...|||.|.|...|.|.:...||:.:.|:.....||.....|:     |...|.::||:....
Zfish  1131 QGASVIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAAAILSVMGRAT 1195

  Fly   975 FNPPLHNAGQIGLAITQALGMTGMVQWGMRQSAELENAMTSVERVLEYKDLDPEGDF---NSPAE 1036
            .:|     |.:|||::.:|.:||::.|.:|...::||.:.|||||.||.:...|..:   :||.
Zfish  1196 LSP-----GTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEAPWTFEDSPL- 1254

  Fly  1037 KQPPKSWPKEGKLVTKDLSLRYEPDTNSPCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFR- 1100
               |..||:.|.:..:...|:|....:  ..||.:|.::...||||||||||||||||...:||
Zfish  1255 ---PSDWPRSGSIGFQAYGLQYRKGLD--WALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRI 1314

  Fly  1101 LSYNDGAILIDSLDTNDIGLHDLRSKISIIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHL 1165
            |....|.|.||.::..:||||:|||:|:||||:||||||::|.|||||::|.|:::|::||..||
Zfish  1315 LEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHL 1379

  Fly  1166 KEEISELPSGLQSIISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQATIR 1230
            |..:|:||..|....||||.|.|:|||||:|||||:||:.:|||:|||||.||.:||.|||:|||
Zfish  1380 KTFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIR 1444

  Fly  1231 NKFKDCTVLTIAHRLNTIMDSDKVLVMDAGHVVEFGSPYELLTASKAKVFHGMVMQTG 1288
            .:|:||||||||||||||||..:|:|||.|::.|..||..|:  |:...|:.|..:.|
Zfish  1445 TQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLI--SQHGQFYRMCREAG 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31793	NP_609930.4	CFTR_protein	1..1273	CDD:273530	455/1341 (34%)
		ABC_membrane	112..364	CDD:294371	74/266 (28%)
		ABCC_MRP_domain1	434..632	CDD:213217	97/200 (49%)
		ABC_membrane	736..955	CDD:294371	65/228 (29%)
		ABCC_MRP_domain2	1047..1268	CDD:213211	124/221 (56%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	459/1358 (34%)
		ABC_membrane	320..587	CDD:294371	74/280 (26%)
		ABCC_MRP_domain1	633..834	CDD:213217	97/201 (48%)
		ABC_membrane	950..1215	CDD:279056	78/274 (28%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	124/221 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850