DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaD and CD36

DIOPT Version :9

Sequence 1:	NP_724087.1	Gene:	ninaD / 326160	FlyBaseID:	FBgn0002939	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_000063.2	Gene:	CD36 / 948	HGNCID:	1663	Length:	472	Species:	Homo sapiens

Alignment Length:	485	Identity:	125/485 - (25%)
Similarity:	214/485 - (44%)	Gaps:	39/485 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CCSCCGVTQQKAWVFG--LGTFFAVSGLLAIICWPGFIDSGIMKALPLTPTSKTFEKWEELPIPV 64
            |...||:      :.|  :|...||.|.:.:......|...|.|.:.|...:..|:.|.:....|
Human     3 CDRNCGL------IAGAVIGAVLAVFGGILMPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEV 61

  Fly    65 YVYMYLWNWTNAADVQANGVKPIFAQLGPYVYR-----EERKKMDLEWHDNGTVTFNPRRTWFWE 124
            |...::::..|..:|..|.......|.|||.||     :|....|.|  || ||:|.......:|
Human    62 YRQFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAE--DN-TVSFLQPNGAIFE 123

  Fly   125 EELSGGKQTDLITAPHLPSLAASNQMRNSNVFLKFMFNEALNANGGHLFVTHTAAEWLFESFYDE 189
            ..||.|.:.|..|..:|...|||:..:|.  |::.:.|..:|.:...:|...|..|.|: .:.|.
Human   124 PSLSVGTEADNFTVLNLAVAAASHIYQNQ--FVQMILNSLINKSKSSMFQVRTLRELLW-GYRDP 185

  Fly   190 FLHYAMTLNNPLVPKIESDHFAWFLNRNGSKDFEGPFTVHTGVGDIKEMGEIKYWKGQNHTGWYD 254
            ||        .|||...:.....|...|.:.|  |.:.|..|..:|.::..|..:||:.:..:::
Human   186 FL--------SLVPYPVTTTVGLFYPYNNTAD--GVYKVFNGKDNISKVAIIDTYKGKRNLSYWE 240

  Fly   255 GECGRLNGSTTDLFVPDEPKEKALTIFIPDTCRIINLEFTGQSE-TIQGITGWKYEITPNTFDNG 318
            ..|..:||:....|.|...|.:.|..|..|.||.|...|  :|: .::||..:::.:....|.:.
Human   241 SHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVF--ESDVNLKGIPVYRFVLPSKAFASP 303

  Fly   319 QINGNAKCWCPLERQPDNCPATGATDLGPCADGVPMYLSADHFMYADESYGSTISGYNPNYDQNN 383
            ..|.:..|:|..:....||.:.|..|:..|.:|.|:|:|..||:||.......|.|.|||.:::.
Human   304 VENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHR 368

  Fly   384 FYIIMERKMGVPLKVNANVMITLYIEPDSVIDILKGLP-SFYAPLFTTASRAEIDEALASELRLA 447
            .|:.:|...|..|:....:.:.|.::|...|.:||.|. ::..|:........|.:..|:..|..
Human   369 TYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQ 433

  Fly   448 LNLPAIGRYTGVGFLCLGCILIAVGILLTI 477
            :.    |:...:|.:.:  ||::||:::.:
Human   434 VT----GKINLLGLIEM--ILLSVGVVMFV 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaD	NP_724087.1	CD36	19..474	CDD:279474	121/461 (26%)
CD36	NP_000063.2	CD36	14..463	CDD:395898	121/468 (26%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:1371676	93..120		10/29 (34%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269\|PubMed:20037584	460..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820