Protein Alignment ninaD and Scarb2

DIOPT Version :10

• Sequence 1: NP_724087.1
• Gene: ninaD / 326160
• FlyBaseID: FBgn0002939
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_446453.1
• Gene: Scarb2 / 117106
• RGDID: 621882
• Length: 478
• Species: Rattus norvegicus
• Alignment Length: 492
• Identity: 135/492 - (27%)
• Similarity: 225/492 - (45%)
• Gaps: 36/492 - (7%)

  Fly     5 CCGVTQQKAWVFGLGTFFAVSGLLAIICWPGFIDSGIMKALPLTPTSKTFEKWEELPIPVYVYMY 69
            ||..|   |....|........||....:...:|..|.|.:.|...:|.|:.||:.|:|||:..|
  Rat     4 CCFYT---AGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLPVYIQFY 65

  Fly    70 LWNWTNAADVQANGVKPIFAQLGPYVYREERKKMDLEWHDNG-TVTFNPRRTWFWEEELSGGKQT 133
            .:|.||..:: ..|..|:..::|||.|||.|.|.::::.:|| |::....:.:.:|...|.|..|
  Rat    66 FFNVTNPEEI-LQGEIPLLEEVGPYTYRELRNKANVQFGENGTTISAVTNKAYIFERNQSVGDPT 129

  Fly   134 -DLITAPHLPSLAASNQMRNSNVFLKFMFNEALNANGGHLFVTHTAAEWLFESFYDEFLHYAMTL 197
             |||...::|.|......:..  ||:.:....|.|....||||||..|.|: .:.||.|    :|
  Rat   130 VDLIRTINIPLLTVVEMAQQP--FLREIIEAMLKAYQQTLFVTHTVHELLW-GYKDEVL----SL 187

  Fly   198 NNPLVPKIESDHFAWFLNRNGSKDFEGPFTVHTGVGDIKEMGEIKYWKGQNHTGWYDGE-CGRLN 261
            .:...|.: |.:|..|..|||:.|  |.:...||..:.....:|..|.|:....|:..: |..:|
  Rat   188 VHIFRPDV-SPNFGLFYERNGTND--GEYVFLTGEDNYLNFTKIVEWNGKTSLDWWTTDTCNMIN 249

  Fly   262 GSTTDLFVPDEPKEKALTIFIPDTCRIINLEFTGQSETIQGITGWKYEITPNTFDNGQINGNAKC 326
            |:..|.|.|...|::.|.||..|.||.:.:.|: ..|.::|:..::|::......|...|..
  Rat   250 GTDGDSFHPLISKDETLYIFPSDFCRSVYITFS-SFENVEGLPAFRYKVPAEILANSSENAG--- 310

  Fly   327 WCPLERQPDNCPATGATDLGPCADGVPMYLSADHFMYADESYGSTISGYNPNYDQNNFYIIMERK 391
            :|..|   .||...|..::..|.:|.|:.:|..||..|||.:.|.|.|..||.:::..::.:...
  Rat   311 FCIPE---GNCMDAGVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPL 372

  Fly   392 MGVPLKVNANVMITLYIEP-DSVIDILKGLPSFYAPLFTTASRAEIDEALASELRLALNLPAIGR 455
            .|:.|:......|..|::. |..:: ...:.:...|:........||:..||:|:..:|...|
  Rat   373 TGIILRGAKRFQINTYVKKLDDFVE-TGNIRTMVFPVMYLNESVLIDKETASQLKSVINTTLI-- 434

  Fly   456 YTGVGFLCLGCILIAVGILLTIKRKWY---GQAELDK 489
            .|.:.:     |::|:|:...:...|.   ||...|:
  Rat   435 VTNIPY-----IIMALGVFFGLIFTWLACRGQGSTDE 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaD	NP_724087.1	CD36	17..476	CDD:460076	127/462 (27%)
Scarb2	NP_446453.1	CD36	28..457	CDD:460076	125/454 (28%)
		Important for interaction with GBA1. /evidence=ECO:0000250	155..191		14/40 (35%)