DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rngo and DDI2

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_115717.3	Gene:	DDI2 / 84301	HGNCID:	24578	Length:	399	Species:	Homo sapiens

Alignment Length:	393	Identity:	195/393 - (49%)
Similarity:	264/393 - (67%)	Gaps:	25/393 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FCLDVAQDLELENLKALCAMEIGAEVSQIAVIFNGRELSSDKQTLQQCGVGDGDFIMLERRRSAN 77
            |.|.|..|.||.|.:|||.:|.|...::..:::..|.|:.:.::|...|:.|||.::|.::.:|:
Human    17 FSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENAD 81

  Fly    78 -RPVGGNPAISTLDFSNIAVPGTSSGGSPPSRRVQQQGVQQPQFN--NLTDIPTTDEFNVNFDDD 139
             ||....|.:..:|||:||||||||    |.:| |..|.||...:  .:|..|       ...|:
Human    82 PRPPVQFPNLPRIDFSSIAVPGTSS----PRQR-QPPGTQQSHSSPGEITSSP-------QGLDN 134

  Fly   140 PETVRQMFLSSPETLSLLRQYNPSLAEAIDSGDKEKFARLLREHITERKRRNEHRMRMLNADPFD 204
            |..:|.|.|::|..||||::.||.||||:.|||.|||:|:|.|...:|.||.:.|:|:.:|||||
Human   135 PALLRDMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFD 199

  Fly   205 EETQRLIAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAFVDSGAQTTIMSKDC 269
            .|.|..|.|:|:|:||::||..|:|..||.||.|.||||||||||.|||||||||||.||||:.|
Human   200 LEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVVMLYINCKVNGHPVKAFVDSGAQMTIMSQAC 264

  Fly   270 AERCHVNRLIDTRWNGVAKGVGTQPILGRIHMVQLQIENDHLTSSFTVLGQQPMDMLLGLDMLKR 334
            ||||::.||:|.||.|:|||||||.|:||:|:.|:|||.|.|..||::|.:||||||||||||||
Human   265 AERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEEQPMDMLLGLDMLKR 329

  Fly   335 HQCLIDLQRNLLIIGTTGTTTPFLPESELPVSARLTGNS-------EDSMEQ---EAISNAIEQS 389
            |||.|||::|:|:|||||:.|.||||.|||..|||...:       |:..:|   ||:..:.|.:
Human   330 HQCSIDLKKNVLVIGTTGSQTTFLPEGELPECARLAYGAGREDVRPEEIADQELAEALQKSAEDA 394

  Fly   390 KRE 392
            :|:
Human   395 ERQ 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563	20/59 (34%)
		DDI1_N	3..72	CDD:176391	20/58 (34%)
		RP_DDI	225..344	CDD:133146	83/118 (70%)
		UBA	411..445	CDD:279021
DDI2	NP_115717.3	Ubl_Ddi1_like	1..76	CDD:340494	20/58 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..134		16/46 (35%)
		RP_DDI	221..343	CDD:133146	85/121 (70%)
		Ubiquitin-binding. /evidence=ECO:0000305\|PubMed:27461074	376..395		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147166
Domainoid	1	1.000	185	1.000	Domainoid score	I3384
eggNOG	1	0.900	-	-		E1_KOG0012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121661
Inparanoid	1	1.050	358	1.000	Inparanoid score	I2227
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54960
OrthoDB	1	1.010	-	-		D495103at33208
OrthoFinder	1	1.000	-	-		FOG0002352
OrthoInspector	1	1.000	-	-		otm40502
orthoMCL	1	0.900	-	-		OOG6_101685
Panther	1	1.100	-	-	O	PTHR12917
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2086
SonicParanoid	1	1.000	-	-		X1784
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800