DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rngo and Ddi1

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_082218.1	Gene:	Ddi1 / 71829	MGIID:	1919079	Length:	408	Species:	Mus musculus

Alignment Length:	396	Identity:	189/396 - (47%)
Similarity:	252/396 - (63%)	Gaps:	31/396 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FCLDVAQDLELENLKALCAMEIGAEVSQIAVIFNGRELSSDKQTLQQCGVGDGDFIMLERRRSAN 77
            |.|.|..|.||.|.:.||.:|.|....:..:::..:.|:.|..:|...|:.|||.::|.::.:..
Mouse    17 FSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVG 81

  Fly    78 -RPVGGNPAISTLDF--SNIAVPGTSSGGSPPSRRVQQQGVQQPQFNNLTDIPTTDEF------- 132
             |..|..|.....||  |..|||||||     ||...|   .|..:::...||:|.:.
Mouse    82 LRTPGRTPNHPRADFTGSGSAVPGTSS-----SRHPHQ---HQHHYHHHQRIPSTQQAHGLASGE 138

  Fly   133 NVNFD---DDPETVRQMFLSSPETLSLLRQYNPSLAEAIDSGDKEKFARLLREHITERKRRNEHR 194
            |:.|.   |.|..:|.|.||:|..||||::.||:||||:.||:.|.|:::|.|...||..|.:..
Mouse   139 NMTFAQELDSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLMEQQRERTLREQEM 203

  Fly   195 MRMLNADPFDEETQRLIAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAFVDSG 259
            .|:.:.:|||:|||..|.|||:|:||::||..|:|..||.||.|.||||||||||.|:|||||||
Mouse   204 FRLYSTNPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSG 268

  Fly   260 AQTTIMSKDCAERCHVNRLIDTRWNGVAKGVGTQPILGRIHMVQLQIENDHLTSSFTVLGQQPMD 324
            ||.||||:.|||||::.||:|.||.|||||||||.|:||:|:.|:|||.|.|..||::|.:||||
Mouse   269 AQMTIMSQACAERCNIMRLVDRRWGGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMD 333

  Fly   325 MLLGLDMLKRHQCLIDLQRNLLIIGTTGTTTPFLPESELPVSARLTGNSEDSMEQEAISNAIEQS 389
            :|||||||:||||.|||::|:|:|||||:.|.||||.|||:.|:|...:    .||      |.|
Mouse   334 ILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGT----VQE------ESS 388

  Fly   390 KRESGG 395
            .||.||
Mouse   389 DREVGG 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563	19/59 (32%)
		DDI1_N	3..72	CDD:176391	19/58 (33%)
		RP_DDI	225..344	CDD:133146	81/118 (69%)
		UBA	411..445	CDD:279021
Ddi1	NP_082218.1	Ubl_Ddi1_like	1..76	CDD:340494	19/58 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..135		20/60 (33%)
		RP_DDI	235..357	CDD:133146	83/121 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..408		6/9 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837109
Domainoid	1	1.000	185	1.000	Domainoid score	I3373
eggNOG	1	0.900	-	-		E1_KOG0012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2225
Isobase	1	0.950	-	0	Normalized mean entropy	S2010
OMA	1	1.010	-	-		QHG54960
OrthoDB	1	1.010	-	-		D495103at33208
OrthoFinder	1	1.000	-	-		FOG0002352
OrthoInspector	1	1.000	-	-		otm42575
orthoMCL	1	0.900	-	-		OOG6_101685
Panther	1	1.100	-	-	O	PTHR12917
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2086
SonicParanoid	1	1.000	-	-		X1784
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750