DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rngo and Ddi2

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001017966.1	Gene:	Ddi2 / 68817	MGIID:	1917244	Length:	399	Species:	Mus musculus

Alignment Length:	391	Identity:	190/391 - (48%)
Similarity:	260/391 - (66%)	Gaps:	21/391 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FCLDVAQDLELENLKALCAMEIGAEVSQIAVIFNGRELSSDKQTLQQCGVGDGDFIMLERRRSAN 77
            |.|.|..|.||.|.:|||.:|.|...::..:::..|.|:.:.::|...|:.|||.::|.::.:|:
Mouse    17 FSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENAD 81

  Fly    78 -RPVGGNPAISTLDFSNIAVPGTSSGGSPPSRRVQQQGVQQPQFNNLTDIPTTDEFNVNFDDDPE 141
             ||......:..:|||:|||||||   :|..|::.:...|......:...|       ...|:|.
Mouse    82 PRPAVQFSNLPRIDFSSIAVPGTS---NPQQRQLPRTQAQHSSPGEMASSP-------QGLDNPA 136

  Fly   142 TVRQMFLSSPETLSLLRQYNPSLAEAIDSGDKEKFARLLREHITERKRRNEHRMRMLNADPFDEE 206
            .:|.|.|::|..||||::.||.||||:.|||.|||:|:|.|...:|.||.:.|:|:.:|||||.|
Mouse   137 LLRDMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLE 201

  Fly   207 TQRLIAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAFVDSGAQTTIMSKDCAE 271
            .|..|.|:|:|:||::||..|:|..||.||.|.||||||:|||.|||||||||||.||||:.|||
Mouse   202 AQAKIEEDIRQQNIEENMTIAMEEAPESFGQVAMLYINCRVNGHPVKAFVDSGAQMTIMSQACAE 266

  Fly   272 RCHVNRLIDTRWNGVAKGVGTQPILGRIHMVQLQIENDHLTSSFTVLGQQPMDMLLGLDMLKRHQ 336
            ||::.||:|.||.|:|||||||.|:||:|:.|:|||.|.|..||::|.:||||||||||||||||
Mouse   267 RCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLACSFSILEEQPMDMLLGLDMLKRHQ 331

  Fly   337 CLIDLQRNLLIIGTTGTTTPFLPESELPVSARL---TGNSEDSMEQ-------EAISNAIEQSKR 391
            |.|||::|:|:|||||:.|.||||.|||..|||   ||..:...|:       |||..:.|.::|
Mouse   332 CSIDLKKNVLVIGTTGSQTTFLPEGELPECARLAYGTGREDIRPEEIADQELAEAIQKSAEDAER 396

  Fly   392 E 392
            :
Mouse   397 Q 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563	20/59 (34%)
		DDI1_N	3..72	CDD:176391	20/58 (34%)
		RP_DDI	225..344	CDD:133146	82/118 (69%)
		UBA	411..445	CDD:279021
Ddi2	NP_001017966.1	DDI1_N	3..76	CDD:176391	20/58 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..134		11/44 (25%)
		RP_DDI	221..343	CDD:133146	84/121 (69%)
		Ubiquitin-binding. /evidence=ECO:0000305	376..395		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3373
eggNOG	1	0.900	-	-		E1_KOG0012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121661
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2225
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54960
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002352
OrthoInspector	1	1.000	-	-		otm42575
orthoMCL	1	0.900	-	-		OOG6_101685
Panther	1	1.100	-	-	O	PTHR12917
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2086
SonicParanoid	1	1.000	-	-		X1784
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860