DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rngo and ddi2

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_031760983.1	Gene:	ddi2 / 619368	XenbaseID:	XB-GENE-6073016	Length:	1056	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	204/422 - (48%)
Similarity:	269/422 - (63%)	Gaps:	36/422 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKITV----TTSDDKVFCLDVAQDLELENLKALCAMEIGAEVSQIAVIFNGRELSSDKQTLQQCG 61
            |.|||    ....:..|.|:|..|.||||.:|||.:|.|...|:..:::..|.|::::::|...|
Frog     1 MLITVYCVRRDLSEVTFSLEVDGDFELENFRALCELESGIPASETLIVYAERPLTNNQRSLASYG 65

  Fly    62 VGDGDFIMLERRRSAN-RPVGGNPAISTLDFSNIAVPGTSSGGSPPSRRVQQQGVQQPQFNNLTD 125
            :.|||.::|.:|.:.. ||....|.   ||||.|||||:||..:|.    |.|....|.
Frog    66 LKDGDVVILRQRETPEARPAAPFPG---LDFSTIAVPGSSSQPAPS----QPQAPPPPP------ 117

  Fly   126 IPTTDEFNVNFDDDPETVRQMFLSSPETLSLLRQYNPSLAEAIDSGDKEKFARLLREHITERKRR 190
             |.|..|.... |:|..:|:|.|::|..||||::.||.||||:.|||.|||.::|.|...||.||
Frog   118 -PDTSSFPQGL-DNPALLREMLLANPHELSLLKERNPPLAEALLSGDLEKFTKVLLEQQQERARR 180

  Fly   191 NEHRMRMLNADPFDEETQRLIAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAF 255
            .:.|:|:.:|||||.|.|..|.|:|:|:||::||..|:|..||.||.|.||||||||||.|||||
Frog   181 EQERIRLYSADPFDLEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVVMLYINCKVNGYPVKAF 245

  Fly   256 VDSGAQTTIMSKDCAERCHVNRLIDTRWNGVAKGVGTQPILGRIHMVQLQIENDHLTSSFTVLGQ 320
            ||||||.||||:.||||||:.||:|.||.|:|||||||.|:||:|:.|:|||.|.|..||::|.:
Frog   246 VDSGAQMTIMSQACAERCHIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLPCSFSILEE 310

  Fly   321 QPMDMLLGLDMLKRHQCLIDLQRNLLIIGTTGTTTPFLPESELPVSARLT---GNSEDSMEQ--- 379
            |||||||||||||||||.|||::|:|:||||||.|.||||.|||..|||.   |..|...|:
Frog   311 QPMDMLLGLDMLKRHQCSIDLEKNVLVIGTTGTRTSFLPEGELPECARLAYGPGREEVRPEEIAD 375

  Fly   380 ----EAISNAIEQSKRESGGAGGGPNTISPQE 407
                |.:..:.|::..|:      .:.:||.:
Frog   376 RELAEVLQKSAEEADTET------TSLVSPTD 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563	26/75 (35%)
		DDI1_N	3..72	CDD:176391	25/72 (35%)
		RP_DDI	225..344	CDD:133146	84/118 (71%)
		UBA	411..445	CDD:279021
ddi2	XP_031760983.1	Ubl_Ddi1_like	1..76	CDD:340494	26/74 (35%)
		RP_DDI	216..338	CDD:133146	86/121 (71%)
		auto_Ag43	785..>988	CDD:380184
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3243
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121661
Inparanoid	1	1.050	364	1.000	Inparanoid score	I2116
OMA	1	1.010	-	-		QHG54960
OrthoDB	1	1.010	-	-		D495103at33208
OrthoFinder	1	1.000	-	-		FOG0002352
OrthoInspector	1	1.000	-	-		oto102547
Panther	1	1.100	-	-	O	PTHR12917
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2086
SonicParanoid	1	1.000	-	-		X1784
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110