DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rngo and Nrip2

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001156330.1	Gene:	Nrip2 / 60345	MGIID:	1891884	Length:	270	Species:	Mus musculus

Alignment Length:	222	Identity:	48/222 - (21%)
Similarity:	89/222 - (40%)	Gaps:	34/222 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 DSGD--KEKFARLL-REHITERKRRNEHRMRMLNADPFD----EETQRLIAEE-------IKQKN 219
            |.||  ||:.|.|. |.|::: :|:.:...:.|:.|..|    :..:||...:       |:::.
Mouse    10 DEGDSRKEQEASLRDRAHLSQ-QRQLKQATQFLHKDSADLLPLDSLKRLGTSKDLQPHSVIQRRL 73

  Fly   220 IQDNMAAAIEYNPEIFG-------------TVTMLYINCKVNGIPVKAFVDSGAQTTIMSKDCAE 271
            ::.|.......:|.:..             .|..|.:|||.....::..||:|.|...:|..|..
Mouse    74 VEGNQRRLQGESPLLQALIRGHDSSRTSATQVPALLVNCKCQDQMLRVAVDTGTQHNQISAGCLR 138

  Fly   272 RCHVNRLIDTRWNG-VAKGVGTQPILGRIHMVQLQIENDHLTSSFTVLGQQPMDMLLGLDMLKRH 335
            |..:.:.:.....| ||....||     :..::|::..:.:..|..|:.....:..|||..|...
Mouse   139 RLGLGKRVPKAPGGDVAPEPPTQ-----VEQLELELGQETVACSAQVVDVDSPEFCLGLQTLLSL 198

  Fly   336 QCLIDLQRNLLIIGTTGTTTPFLPESE 362
            :....|..:.|:....|..|..:.:||
Mouse   199 KLATSLSASSLLPSALGIPTESICDSE 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563
		DDI1_N	3..72	CDD:176391
		RP_DDI	225..344	CDD:133146	26/132 (20%)
		UBA	411..445	CDD:279021
Nrip2	NP_001156330.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		9/23 (39%)
		Interaction with NR1F2. /evidence=ECO:0000269\|PubMed:10860982	61..99		3/37 (8%)
		pepsin_retropepsin_like	110..199	CDD:299705	22/93 (24%)
		LXXLL motif	192..196		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12917
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910