DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rngo and NRIP3

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_065696.1	Gene:	NRIP3 / 56675	HGNCID:	1167	Length:	241	Species:	Homo sapiens

Alignment Length:	253	Identity:	52/253 - (20%)
Similarity:	106/253 - (41%)	Gaps:	57/253 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 ETLSLLRQYNPSLAEAI-----DSGD--------KEKFARLLREHITERKRRNEHRMRMLNAD-- 201
            |..||.:|..  :.:|:     ||.|        |...::.::.|...::|..|..:..|.:.
Human    19 EAASLRQQRR--MKQAVQFIHKDSADLLPLDGLKKLGSSKDMQPHNILQRRLMETNLSKLRSGPR 81

  Fly   202 -PFDEETQRL---IAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAFVDSGAQT 262
             |:..:|.:|   .:|.:|:....|                 |:.::|:..|..|||.||:|...
Human    82 VPWASKTNKLNQAKSEGLKKSEEDD-----------------MILVSCQCAGKDVKALVDTGCLY 129

  Fly   263 TIMSKDCAERCHVNRLIDTRWNGVAKGVGTQ-------PILGRIHMVQLQIENDHLTSSFTVLGQ 320
            .::|..|.:|..:...:.:.     |..|.:       .::|:|..:.:.:.:..|.....|:..
Human   130 NLISLACVDRLGLKEHVKSH-----KHEGEKLSLPRHLKVVGQIEHLVITLGSLRLDCPAAVVDD 189

  Fly   321 QPMDMLLGLDMLKRHQCLIDLQRNLLIIGTTGTTTPFLPESELPVSARLTGNSEDSME 378
            ...::.|||..|:..:|:|:|.::.||:|.|       .:.|:|....::.|.:::.|
Human   190 NEKNLSLGLQTLRSLKCIINLDKHRLIMGKT-------DKEEIPFVETVSLNEDNTSE 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563
		DDI1_N	3..72	CDD:176391
		RP_DDI	225..344	CDD:133146	25/125 (20%)
		UBA	411..445	CDD:279021
NRIP3	NP_065696.1	NRIP_C	110..212	CDD:133147	24/106 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12917
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910