DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rngo and mud1

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001018195.1	Gene:	mud1 / 3361477	PomBaseID:	SPAC56F8.08	Length:	332	Species:	Schizosaccharomyces pombe

Alignment Length:	362	Identity:	128/362 - (35%)
Similarity:	184/362 - (50%)	Gaps:	67/362 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 NNLTDIPTTDEFNVNFDDDPETVRQMFLSSPETLSLLRQYNPSLAEAIDSGDKEKFARLLREHIT 185
            ||||               ||.:||..|::|..|:.:|...|.||..::  |...||       |
pombe     2 NNLT---------------PENIRQTILATPFLLNRIRTEFPQLAAVLN--DPNAFA-------T 42

  Fly   186 ERKRRNEHRMRMLNA-------------DPFDEETQRLIAEEIKQKNIQDNMAAAIEYNPEIFGT 237
            ..:..|..::..:.:             |.||.|.||.|.|:|:|..:.:||.:|||.:||:||.
pombe    43 TWQSINASQLLQIPSSTYSMGMPSFSEDDLFDVEVQRRIEEQIRQNAVTENMQSAIENHPEVFGQ 107

  Fly   238 VTMLYINCKVNGIPVKAFVDSGAQTTIMSKDCAERCHVNRLIDTRWNGVAKGVGTQPILGRIHMV 302
            |.||::|.::||..||||||||||.||:|.||||:|.:.||:|||:.|||||||...|||.:|..
pombe   108 VYMLFVNVEINGHKVKAFVDSGAQATILSADCAEKCGLTRLLDTRFQGVAKGVGMAKILGCVHSA 172

  Fly   303 QLQIENDHLTSSFTVLGQQPMDMLLGLDMLKRHQCLIDLQRNLLIIGTTGTTTPFLPESELPVSA 367
            .|:|.:.:|...|||:..:.:|||||||||:|:|..|||:.|:|.|  .|...|||.|||:|
pombe   173 PLKIGDLYLPCRFTVIEGRDVDMLLGLDMLRRYQACIDLENNVLRI--HGKEIPFLGESEIP--- 232

  Fly   368 RLTGNSEDSMEQEAISNAIEQSKRESG----------------------GAGGGPNTIS-PQERF 409
            :|..|.|.|.....:  .||.:.:.|.                      |:...|:.:: |.:..
pombe   233 KLLANVEPSANAHGL--GIEPASKASASSPNPQSGTRLGTKESVAPNNEGSSNPPSLVNPPTDPG 295

  Fly   410 TEQDVTDLMALGYPRSDVLTVLRLCGGNKQAARSVLL 446
            ....:..|:::|:...:....|....|:...|.|.||
pombe   296 LNSKIAQLVSMGFDPLEAAQALDAANGDLDVAASFLL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563
		DDI1_N	3..72	CDD:176391
		RP_DDI	225..344	CDD:133146	67/118 (57%)
		UBA	411..445	CDD:279021	6/33 (18%)
mud1	NP_001018195.1	Asp_protease	87..210	CDD:118200	67/122 (55%)
mud1	NP_001018195.1	UBA_Mud1_like	297..332	CDD:270493	6/34 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	141	1.000	Domainoid score	I1202
eggNOG	1	0.900	-	-		E1_KOG0012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I1063
OMA	1	1.010	-	-		QHG54960
OrthoFinder	1	1.000	-	-		FOG0002352
OrthoInspector	1	1.000	-	-		oto100612
orthoMCL	1	0.900	-	-		OOG6_101685
Panther	1	1.100	-	-	LDO	PTHR12917
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2086
SonicParanoid	1	1.000	-	-		X1784
TreeFam	1	0.960	-	-
	13	12.860