DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rngo and ddi-1

DIOPT Version :9

Sequence 1:	NP_001285328.1	Gene:	rngo / 32616	FlyBaseID:	FBgn0030753	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_500992.1	Gene:	ddi-1 / 177413	WormBaseID:	WBGene00015308	Length:	389	Species:	Caenorhabditis elegans

Alignment Length:	321	Identity:	103/321 - (32%)
Similarity:	165/321 - (51%)	Gaps:	64/321 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GTSSGGSPPSRRVQQQGVQQPQFNNLTDIPTTDEFNVNFDDDPETVRQMF----LSSPETLSLLR 158
            |.||..:..::|.::  |:|                   ||:.|  :.||    |.||.|...|.
Worm   107 GQSSSSAQSAQRTRR--VEQ-------------------DDEGE--KSMFSRKLLDSPATFKALS 148

  Fly   159 Q--------------YN-PSLAEAI----DSGDKEKFARLLREHITERKRRNEHRMRMLNADPFD 204
            :              |. |.|.|..    |...|| |.::.|.::.|    ..|:..::..:|..
Worm   149 ENMFFRLKNEPHKLGYGLPELVERFLAKKDMTYKE-FEQMFRSYVEE----EVHKEEIIKNNPNS 208

  Fly   205 EETQRLIAEEIKQKNIQDNMAAAIEYNPEIFGTVTMLYINCKVNGIPVKAFVDSGAQTTIMSKDC 269
            .|.:..:..:..::.|.:....::.::||....|||||||..:||:|||||:|||||.:|||..|
Worm   209 AEAKMFLEAKRNKELIDEQYLHSMTHHPEDMIAVTMLYINLTINGVPVKAFIDSGAQKSIMSMAC 273

  Fly   270 AERCHVNRLIDTRWNGVAKGV-GTQPILGRIHMVQLQIENDHLTSSFTVLGQQPMDMLLGLDMLK 333
            ||||.:|.|||.|:..:|:|| ||:.|.|:||:..:::|:.|.:..|.|:.::.||:|:||::|:
Worm   274 AERCGLNGLIDRRFQSMARGVGGTEKIEGKIHLCDVKVEDAHFSCPFEVMARREMDLLIGLNVLR 338

  Fly   334 RHQCLIDLQRNLLIIGTTGTTTPFLPESELPVSARLTGNSEDSMEQEAISNAIEQSKRESG 394
            :|.|.|:|:.:.|..| .|||||||..:|:           ||..:|.::...|:.:.|.|
Worm   339 KHGCCINLKTSRLEFG-NGTTTPFLQSNEI-----------DSHLKEIMALPEEEMQFEDG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rngo	NP_001285328.1	UBQ	1..73	CDD:214563
		DDI1_N	3..72	CDD:176391
		RP_DDI	225..344	CDD:133146	57/119 (48%)
		UBA	411..445	CDD:279021
ddi-1	NP_500992.1	Asp_protease	221..345	CDD:312981	56/123 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I3489
eggNOG	1	0.900	-	-		E1_KOG0012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2010
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495103at33208
OrthoFinder	1	1.000	-	-		FOG0002352
OrthoInspector	1	1.000	-	-		oto20035
orthoMCL	1	0.900	-	-		OOG6_101685
Panther	1	1.100	-	-	LDO	PTHR12917
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2086
SonicParanoid	1	1.000	-	-		X1784
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760