DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31773 and MET7

DIOPT Version :9

Sequence 1:	NP_722953.1	Gene:	CG31773 / 326159	FlyBaseID:	FBgn0051773	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_014884.1	Gene:	MET7 / 854415	SGDID:	S000005767	Length:	548	Species:	Saccharomyces cerevisiae

Alignment Length:	519	Identity:	142/519 - (27%)
Similarity:	231/519 - (44%)	Gaps:	79/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 KSPEHL---AYLDAIKQLNSYQVLEPTSGRATTKSSRKEQDPVIEQTL----ECLEKSGLTKKDL 326
            |:|..:   .|.||:..|||.|     |..|...:.|:..|.....||    |...:.|.:..|.
Yeast    58 KNPLRMVGKTYRDAVTALNSLQ-----SNYANIMAIRQTGDRKNTMTLLEMHEWSRRIGYSASDF 117

  Fly   327 KAIPVIQVAGSKGRGSTCAIVESILRCHG---VKTGVLSSPHLFLTSERIRIDGEPLSDVQFTEL 388
            ..:.::.:.|:||:|||.|...|||..:.   .:.|:.:||||....|||||:|||:|:.:|.:.
Yeast   118 NKLNIVHITGTKGKGSTAAFTSSILGQYKEQLPRIGLYTSPHLKSVRERIRINGEPISEEKFAKY 182

  Fly   389 FWKINTDL----------ANMQP--TPSYNKIMTVMAFHAFHQAGVEVAILEVGNAGASDATNIA 441
            |:::...|          .:|.|  .|.|.|.:|:::||.|.|...:..:.|||..|..|:|||.
Yeast   183 FFEVWDRLDSTTSSLDKFPHMIPGSKPGYFKFLTLLSFHTFIQEDCKSCVYEVGVGGELDSTNII 247

  Fly   442 SHAQTIGITTLGWEQSSNLGNSLRDIAWAKASIMKPEANIYTNVTQ-TECCEVLAQKAKQIGAQL 505
            ......|:|.||.:.:..||:::.:|||.|..|.|..|..:|...| .:...:|.::|::....|
Yeast   248 EKPIVCGVTLLGIDHTFMLGDTIEEIAWNKGGIFKSGAPAFTVEKQPPQGLTILKERAEERKTTL 312

  Fly   506 RRVPTFNDYVEGDMNNKLLMNKANYSMRLNGSLAVQLAYDFLKRHK--------------PE-YV 555
            ..||.|...      ..:.:..|....:.|.||||.||.:.|....              || ::
Yeast   313 TEVPPFKQL------ENVKLGIAGEFQKSNASLAVMLASEILHTSNILEEKIKCSSNASIPEKFI 371

  Fly   556 VGLEHNSTLLTPGASRGIEIFEQPGHFDFMRHDMFNV-YLDSADTFESMMACRDWFYTRTRANRQ 619
            :||::     |....| .::.|:..          || |:|.|.|.:||:|...||....|.:::
Yeast   372 IGLQN-----TKWEGR-CQVLEKGK----------NVWYIDGAHTKDSMVAASTWFRDMVRLSKR 420

  Fly   620 PKILLFNKVN-EFNA--KDLLTIIRSNLRFEEACFVPNPNYFEGEILAEEDGKAMVWHGMEELQR 681
            .||||||:.: :.||  .:|.:.:...:.|::..|..|..:..|...|:..........:|:|:.
Yeast   421 KKILLFNQQSRDANALVNNLYSSVSPEITFDDVIFTTNVTWKSGSYSADLVSMNTSQEDVEKLKV 485

  Fly   682 AKRNAGNWRALCEENGKRDNSQLSISINAFFEYLTNKYGKQKYGMKNELDVLVTGSRQLVAATI 745
            .:....||..:.:...|   :.::.||....|.:...|.:       ..|:.||||..||...:
Yeast   486 QESLVKNWNKIDDNRAK---THVTASIEEANELIETLYDE-------PADIFVTGSLHLVGGLL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31773	NP_722953.1	folC	309..745	CDD:273659	129/474 (27%)
MET7	NP_014884.1	folC	100..542	CDD:273659	128/472 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0285
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1575
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001698
OrthoInspector	1	1.000	-	-		otm46841
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11136
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2113
TreeFam	1	0.960	-	-
	9	8.750