DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31773 and sns

DIOPT Version :9

Sequence 1:	NP_722953.1	Gene:	CG31773 / 326159	FlyBaseID:	FBgn0051773	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster

Alignment Length:	882	Identity:	166/882 - (18%)
Similarity:	267/882 - (30%)	Gaps:	329/882 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ALQWTIQSSQNFFKMSFKAPSIKVPKAAAIKELANKPTQPQSQPSQSQSSATQPTQPPQQAEIKK 82
            |:|||    ::.|.:.|.|.....|:.:.:.:      :.|...:...|:|:.......|.::..
  Fly   101 AVQWT----KDGFALGFSAVIPGFPRYSVLGD------RKQGIYNLRISNASINDDADYQCQVGP 155

  Fly    83 NPLTMGAISPAPPTPISPKPSVQPKIPDQRAKWMAKVSPESQRKAKLAAA---------GGSPPS 138
            ..|.....:.|..|.|||..|::.|.....:|...:.:.:.|.|..:|.|         .|:...
  Fly   156 ARLNSAIRANAKLTVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEY 220

  Fly   139 GPPKNQFS----------------------------------QANNPSFAM-----------PGQ 158
            .|.|.:.:                                  :|.:|...|           ||.
  Fly   221 KPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGP 285

  Fly   159 SSPANFSAAPKTQASWQQKVEKSAENEDSGAFKGASSESQRKNWMNRMQGSQQR---------KQ 214
            .....:||....:..  |.||....:      :|.:..:|...:.|   |||.|         .:
  Fly   286 PYIEGYSAGETLRRG--QTVELMCRS------RGGNPPAQLIWYKN---GSQIRMAYRTSGRLSE 339

  Fly   215 NQWLKEMQAKQQAGK------DIQAQKMQKMESQKA-----TTTPAAPPKEA------------A 256
            |.:....:|.....:      ::.:|...|.|.:.:     |......|.||            |
  Fly   340 NIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTA 404

  Fly   257 PSTPQPAEKPEEKSPEHLAYL---DAIKQLNSYQVLEPTSGRATTKSSRKEQDPVIEQTLECLEK 318
            ||.| |||         :.::   ..::...|..::.|..|..||.:.....:|
  Fly   405 PSNP-PAE---------IKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEP----------- 448

  Fly   319 SGLTKKDLKAIPVIQVAGSKGRGSTCAIVESILRCHGVKTGVLSSPHLFLTSERIRIDGEPLSDV 383
               .|:.|..|         ..|....:.|:::..|.:  .||..|...|.|..:.....|...|
  Fly   449 ---NKRSLVVI---------CHGLNMQLTENVVSTHTI--NVLYPPAPPLISGYMEGQIIPAGSV 499

  Fly   384 QFTELFWKINTDLANMQPTPSYNKIMTVMAFHAFHQAGVEVAILEVGNAGASD--------ATNI 440
            |...........||.:....:..:|.:|:. .|......|:.||    |..||        |:|.
  Fly   500 QKLLCVSSGGNPLATLTWYKNDKRINSVIR-AADKSVSAEITIL----ANVSDNQAQYRCEASNS 559

  Fly   441 ASHAQTIGITTL--------------------GWEQS----SNLGNSLRDIAWAKASI------- 474
            |:.......|||                    |.|.:    |:..|....::|.|..|
  Fly   560 ATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINN 624

  Fly   475 -MKP--------EANIYTNVTQTECCEVLAQKAKQIGAQLRRVPTFNDYVEGDMNNKL-LMNKAN 529
             .||        ......||||                              :||.:: ....||
  Fly   625 TSKPGLWGGTVSTLEFRVNVTQ------------------------------EMNGQVYTCQSAN 659

  Fly   530 YSMRLNGSLAVQLAYDFLKRHKPEYV-------VGLEHNS-----------------------TL 564
            .:::.:...||.|  |.|  ::|::|       ||:|..|                       |:
  Fly   660 EALQRSAHEAVSL--DVL--YRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTI 720

  Fly   565 LTPGASRGIEIFEQPGHFDFMRHDMFNVYLDSADTFESMMACRDWFYTRTRANRQPKILL-FNKV 628
            ...|..|   ||...|..:|.|     ::.|.|.           .|:.:.:|.|....| ...|
  Fly   721 PQDGDHR---IFADGGSLNFTR-----LHRDDAG-----------IYSCSASNSQGGATLNITVV 766

  Fly   629 NEFNAKDLLTIIRS---NLRFEEACFVPNPN-------YFEGEILAEEDGKAMVWH--GME---- 677
            .|:.     |.|:|   |:       |.||.       ..||:.|.||..|   |.  |.:
  Fly   767 VEYG-----TTIKSVSENI-------VVNPGEDAMLSCTVEGKPLTEEHVK---WERVGYDMTVK 816

  Fly   678 ------------ELQRAKR-NAGNWRALCEENGKRDN 701
                        .::.||| :.||:|  |..:.:.||
  Fly   817 TSTTFANGTSYLHIKDAKREDVGNFR--CVADNRVDN 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31773	NP_722953.1	folC	309..745	CDD:273659	99/502 (20%)
sns	NP_001036532.1	I-set	73..170	CDD:254352	14/78 (18%)
		Ig	76..155	CDD:299845	12/63 (19%)
		IG_like	186..279	CDD:214653	11/92 (12%)
		Ig	197..279	CDD:299845	10/81 (12%)
		IG_like	296..376	CDD:214653	15/90 (17%)
		Ig	300..361	CDD:299845	12/71 (17%)
		Ig	380..454	CDD:299845	18/97 (19%)
		IG_like	490..573	CDD:214653	20/87 (23%)
		Ig	501..560	CDD:299845	13/63 (21%)
		Ig	584..666	CDD:299845	17/111 (15%)
		IG_like	585..666	CDD:214653	17/110 (15%)
		I-set	678..767	CDD:254352	20/107 (19%)
		IGc2	692..757	CDD:197706	14/83 (17%)
		Ig	788..849	CDD:143165	15/65 (23%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900