DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31773 and ed

DIOPT Version :9

Sequence 1:	NP_722953.1	Gene:	CG31773 / 326159	FlyBaseID:	FBgn0051773	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster

Alignment Length:	782	Identity:	131/782 - (16%)
Similarity:	229/782 - (29%)	Gaps:	313/782 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 AEIKKNPLTMGAISPAPPTPISPKPSVQPKIPDQRAKWMAKVSPESQRKAKLAAAGGSPPSGPPK 142
            |::.:....:..::|..|..|||..             :|..:.:...:...::.||||  .|..
  Fly   135 ADVHQEFHNLTVLTPPHPPVISPGN-------------IAVATEDKPMELTCSSIGGSP--DPTI 184

  Fly   143 NQFSQANN---PSFAMPG----QSSPANFSAAPKTQASWQQKVEKSAENEDSGAFKGASSESQRK 200
            ..:.:.:|   |:..:.|    |.:.|..|..|:              .||.||.......::..
  Fly   185 TWYREGSNTPLPATVLKGGTKDQPTNATLSIIPR--------------REDDGAKYKCVVRNRAM 235

  Fly   201 NWMNRMQGSQQRKQNQWLKEMQAKQQAGKDIQAQKMQKMESQKATTTPAAPPKEAAPSTPQPAEK 265
            |...|::.:.....|.:                                 |..|..|..|...|:
  Fly   236 NEGKRLEATATLNVNYY---------------------------------PRVEVGPENPLRVER 267

  Fly   266 PEEKSPEHLAYLDAIKQLNSYQ----------VLEPTSGRATTKSSRKEQDPVIEQTLECLEKSG 320
              :::.:....:||..::.:.:          .|..|..|.:.:.:.|         ..|:..:|
  Fly   268 --DRTAKLECNVDAKPKVPNVRWNRNGRFISSSLVHTIHRVSVQDAGK---------YTCIADNG 321

  Fly   321 LTKKDLKAI------PVIQVAGSKGR----GSTCAIVESILRCHGVKTGVLSSPHLFLTSERIRI 375
            |.|...:.:      |.:.|..||.|    |.|..|     ||:     |.::|
  Fly   322 LGKTGEQELILDILYPPMVVIESKTREAEEGDTVTI-----RCN-----VTANP----------- 365

  Fly   376 DGEPLSDVQFTELFWKINTDLANMQPTPSYN-KIMTVMAFHAFHQAGVEVAILEVGNAGASDATN 439
              .|::      :.|     |....|...|| .::|:.:..|.|                  |.|
  Fly   366 --APVT------IEW-----LKENSPDFRYNGDVLTLTSVRADH------------------AGN 399

  Fly   440 IASHAQTIGITTLGWEQSSNLGNSLRDI------AWAKASIMKPEANIYTNVTQTECC------- 491
            ....|..| :.:.|.|:|..:|||...:      ..|..:..||..::...||.| |.
  Fly   400 YICRAVNI-MQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLT-CSANPPGWP 462

  Fly   492 ------------------EVLAQ-------KA-------------KQIG--------AQLRRVPT 510
                              ::|||       ||             .::|        .::.:.|.
  Fly   463 VPQYRWFRDMDGEFSSTQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQ 527

  Fly   511 F----------------------------------NDYVEGDMNNKLLMNKANYSMRLNGSLAVQ 541
            |                                  .|.||......|...:.|....|||.:.||
  Fly   528 FLAKLQQHMTRRVADTDYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQTNPDQGLNGMVTVQ 592

  Fly   542 LAYDFLKRHKPEYVVGLEHNSTLLTPGASRGIEIFEQPGHFDFMRHDMFNVYLDSADTFESMMAC 606
            ....|..:.:|        |...|.|| .||:...               :|.:..::..|.|
  Fly   593 SQLKFRGKARP--------NGNALVPG-DRGLYTC---------------LYQNEVNSANSSM-- 631

  Fly   607 RDWFYTRTRANRQPKIL-LFNKVNEFNAKDLLTIIRSNLRFEEACFV---PNPNYFEGEILAEED 667
                  :.|...:|.:| .:||| .|:.::...::         |.|   |.|.:
  Fly   632 ------QLRIEHEPIVLHQYNKV-AFDIRETAEVV---------CKVQAYPKPEF---------- 670

  Fly   668 GKAMVWH-GMEELQRAKRNAGNWRALCEENGKRDNSQLSISINAFFEYLTNKYGKQKYGMKNELD 731
                .|. |.........:.|::    |.:...||:.:..|:........:.||:....:.|.||
  Fly   671 ----QWQFGNNPSPLTMSSDGHY----EISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLD 727

  Fly   732 VL 733
            .:
  Fly   728 TI 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31773	NP_722953.1	folC	309..745	CDD:273659	94/534 (18%)
ed	NP_001260013.1	Ig	50..147	CDD:299845	1/11 (9%)
		I-set	146..249	CDD:254352	24/131 (18%)
		Ig	168..249	CDD:299845	18/96 (19%)
		IGc2	268..323	CDD:197706	8/63 (13%)
		Ig_3	341..406	CDD:290638	23/116 (20%)
		Ig_2	437..514	CDD:290606	12/77 (16%)
		I-set	526..633	CDD:254352	23/138 (17%)
		Ig	546..632	CDD:143165	21/117 (18%)
		IG_like	654..736	CDD:214653	16/103 (16%)
		Ig	656..734	CDD:143165	16/101 (16%)
		FN3	741..848	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900