DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31773 and FPGS

DIOPT Version :9

Sequence 1:	NP_722953.1	Gene:	CG31773 / 326159	FlyBaseID:	FBgn0051773	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_004948.4	Gene:	FPGS / 2356	HGNCID:	3824	Length:	587	Species:	Homo sapiens

Alignment Length:	511	Identity:	156/511 - (30%)
Similarity:	230/511 - (45%)	Gaps:	64/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 QAGKDIQAQKMQKMESQKATTTPAAPPKEAAPSTPQPAEKPEEKSPEHLAYLDAIKQLNSYQVLE 290
            :|...::|.......|.:..||..| .:....:.|.|.|...|       |.||::.||:.|
Human     3 RARSHLRAALFLAAASARGITTQVA-ARRGLSAWPVPQEPSME-------YQDAVRMLNTLQ--- 56

  Fly   291 PTSGRATTKSSRKEQDPVIEQTLECLE----KSGLTKKDLKAIPVIQVAGSKGRGSTCAIVESIL 351
             |:.....:..|:..||  :..||.:|    :|||..:||..:.:|.|.|:||:|||||..|.||
Human    57 -TNAGYLEQVKRQRGDP--QTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECIL 118

  Fly   352 RCHGVKTGVLSSPHLFLTSERIRIDGEPLSDVQFTELFWKI-----NTDLANMQPTPSYNKIMTV 411
            |.:|:|||..|||||....|||||:|:|:|...||:.||::     .|...:....|.|.:.:|:
Human   119 RSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRFLTL 183

  Fly   412 MAFHAFHQAGVEVAILEVGNAGASDATNIASHAQTIGITTLGWEQSSNLGNSLRDIAWAKASIMK 476
            ||||.|.|..|::|::|||..||.|.|||.......|:::||.:.:|.||:::..|||.|..|.|
Human   184 MAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFK 248

  Fly   477 PEANIYTNVTQTECCEVLAQKAKQIGAQLRRVPTFNDYVEGDMNNKLLMNKANYSMRLNGSLAVQ 541
            .....:|.:.......||..:|:||...|...|......||  ...|.:.......|.|.:||:|
Human   249 QGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEG--GPPLTLGLEGEHQRSNAALALQ 311

  Fly   542 LAYDFLKRHKPEYVVGLEHNSTLLTPGASR---------------------GIEIFEQPGHFDFM 585
            ||:.:|:|..       .|.:.  .|.|||                     |:...|.||....:
Human   312 LAHCWLQRQD-------RHGAG--EPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEWPGRTQVL 367

  Fly   586 RHDMFNVYLDSADTFESMMACRDWFYTRTRANRQP------KILLFNKVNEFNAKDLLTIIRSNL 644
            |......|||.|.|..|..||..||....:...:|      ::||||...:.:...||.:::. .
Human   368 RRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQP-C 431

  Fly   645 RFEEACFVPNPNYFEGEILAEEDGKAMVWHGMEELQRAKRNAGNWRALCEENGKRD 700
            :|:.|.|.||.........|::....:...  :.|.|...:..:|..|.||....|
Human   432 QFDYAVFCPNLTEVSSTGNADQQNFTVTLD--QVLLRCLEHQQHWNHLDEEQASPD 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31773	NP_722953.1	folC	309..745	CDD:273659	136/428 (32%)
FPGS	NP_004948.4	PLN02881	42..581	CDD:215476	147/471 (31%)
FPGS	NP_004948.4	Mur_ligase_C	360..441	CDD:280948	23/81 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159443
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0285
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1575
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D231485at33208
OrthoFinder	1	1.000	-	-		FOG0001698
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11136
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2113
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.760