DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31773 and syg-2

DIOPT Version :9

Sequence 1:	NP_722953.1	Gene:	CG31773 / 326159	FlyBaseID:	FBgn0051773	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	701	Identity:	126/701 - (17%)
Similarity:	211/701 - (30%)	Gaps:	246/701 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 SPANFSAAPKTQASWQQKVEKSAE-------NEDSGAFKGASSESQRKNWMNRMQGSQQRKQNQW 217
            ||:|.|.......:::...|||.|       ..::|:..|...|........|....:|..:...
Worm    24 SPSNLSTIAGESITFRCSAEKSPEPIVYSQWKSNTGSLLGYHQEGILPGHQGRFSYIKQNAEELH 88

  Fly   218 LKEMQAKQQAGKDIQAQKMQKMES---QKATTTPAAPP----------------KEAAP---STP 260
            ||..........:.:.|.:...|.   .|:......||                ||..|   :..
Worm    89 LKITHVNLDDDGEYECQMLHPEEGPIRAKSFLNIIVPPQLVYFSNYQPNSIIAVKENTPLNITCV 153

  Fly   261 QPAEKPEEKSPEHLAYLDA------IKQLNSYQVLEPTSGRATT-------KSSRKEQDPVIEQT 312
            .|..|||   ||.|.|:|.      :||.::     |...:..|       :|.|.:...||  |
Worm   154 VPNVKPE---PEVLWYMDGKVMSRDVKQAST-----PHLNKTFTVYTSLVVQSDRNDHGKVI--T 208

  Fly   313 LECLEKSGLTKKDLKAIPVIQVAGSKGRGSTCAIVESILRCHGVKTGVLSSPHLFLTSERIRI-- 375
            .|..:|    :.|:             |.:|...::.:.........:|.:|....:.:.:.|
Worm   209 CEAFQK----ETDI-------------RITTNTTLDVLFPPSDPTVEILRNPSALRSGDNVTIAC 256

  Fly   376 ---DGEPLSDVQFTELFWKINTDLANMQPTPSYNKIMTVMAFHAFHQAGVEVAILEVGNAGASDA 437
               .|.|..||     ||              |::...:.:.........|  |..:.:..||..
Worm   257 SVTGGNPPPDV-----FW--------------YHENKRLQSHSTLDTRSKE--IKNIYSFIASQN 300

  Fly   438 TNIASHAQTIGITTLGWEQSSNLGNSLR-----DIAWAKASI-MKPEANI-YTNVTQTECCEVLA 495
            .|:|.:...        ..:|..||..|     ::.:..||: :..|:|| |.:....:|..:.:
Worm   301 DNMAEYECR--------ANNSRTGNPKRKAMKLEVNYPPASVELFGESNIRYGSSANIQCKSLPS 357

  Fly   496 QKAKQ----IGAQLRRVPTFNDYVEGDMNNKLLMNKANYSMRLN-------------------GS 537
            ..|.|    |..:....||..::|   :.|. :::.:|.|:..|                   ||
Worm   358 NPASQITWIINGRSVPTPTQREFV---VENG-IVSSSNVSVHSNELSVEAHQINVECMATNPEGS 418

  Fly   538 LAVQLAYDFLKRHKPEYVVGLEHNSTLLTPGASRGIEIFEQPGHFDFMRHDMFNVYLDSADTFES 602
            .|.|.....:...|...:.|||...                     |...|:.||      |.|:
Worm   419 SAKQHVIKIIAPPKAPIITGLEDRK---------------------FFEGDIVNV------TCEA 456

  Fly   603 M----MACRDWFYTRTRANRQPKIL------------LFNKVNEFNAKDLLTIIRSNLRFEEACF 651
            .    :|...|:    |.:.:..:.            ..|:|..|::...|.:
Worm   457 QGGNPLAELSWY----RGSEKHLVKGRKKMKWSQVNGAHNEVAGFSSYSTLAL------------ 505

  Fly   652 VPNPNYFEGEILAEEDGKAMVWHGMEELQRAKRNAGNWRALCEENGKRDNSQLSISINAFFEYLT 716
                                         |..|.....|..||......:..|..|     :||:
Worm   506 -----------------------------RVDRTMNTQRLKCEATNAALDEPLIES-----QYLS 536

  Fly   717 NKYGKQKYGMK----NELDVLVTGSRQLVAATISCLRKMKSSNP-----WQ 758
            ..|..::..::    .:..:||..|.:||..|:       ||||     ||
Worm   537 VYYPPRRVLIRPADSGDQRLLVGKSARLVCGTL-------SSNPAAHISWQ 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31773	NP_722953.1	folC	309..745	CDD:273659	80/490 (16%)
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653	14/79 (18%)
		Ig	33..122	CDD:299845	14/88 (16%)
		Ig	147..228	CDD:299845	24/107 (22%)
		IGc2	248..313	CDD:197706	14/93 (15%)
		Ig	450..537	CDD:299845	20/142 (14%)
		Ig	559..632	CDD:299845	10/29 (34%)
		I-set	657..738	CDD:254352
		Ig	665..738	CDD:299845
		IG_like	748..828	CDD:214653
		IGc2	756..817	CDD:197706
		Ig	845..922	CDD:299845
		FN3	934..1023	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900