DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31759 and NOCT

DIOPT Version :9

Sequence 1:	NP_723735.2	Gene:	CG31759 / 326158	FlyBaseID:	FBgn0051759	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_036250.2	Gene:	NOCT / 25819	HGNCID:	14254	Length:	431	Species:	Homo sapiens

Alignment Length:	408	Identity:	122/408 - (29%)
Similarity:	176/408 - (43%)	Gaps:	90/408 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 QYLVTPEDIGYHLKFVVTPGNALGMTGPVVEKITNSAVQESPGRCPFQ-DRQRHTTNSLSESNEI 237
            :|||:|:.  .||: .:.|...|        :...:.:...|.|  || |.....|:..|....|
Human    92 EYLVSPDP--EHLE-PIDPKELL--------EECRAVLHTRPPR--FQRDFVDLRTDCPSTHPPI 143

  Fly   238 RVVSYNLLADLYASSDYAGSTLFSYCPAKYLQIDYRKPLFINEIIGYNSDILCLQEVDQRIFDFD 302
            ||:.:|:||.....    |...|..||.:.|:.:.||.|.:.||:.|..||||||||| ..|| .
Human   144 RVMQWNILAQALGE----GKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVD-HYFD-T 202

  Fly   303 LKEILEQPPYNYHGIMAPK--GKC--------AEGVAIFFRNSRFDLLDSQILHLGSNIPALPVF 357
            .:.:|.:  ..|.|...||  ..|        .:|.|:||..:||.|::|      :|| .|...
Human   203 FQPLLSR--LGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNS------ANI-RLTAM 258

  Fly   358 ESLWNKIKVNAQLAERICERSTTLQTCLLRIKGTDNYVLVANTHLYFHPDADHIRLLQMGFSMLF 422
            ....|::.: ||..|  |:.|.. |.|            :|.|||......:..|..| |..:|.
Human   259 TLKTNQVAI-AQTLE--CKESGR-QFC------------IAVTHLKARTGWERFRSAQ-GCDLLQ 306

  Fly   423 VEQSISKAIKDFNISSHKNIGLIFCGDFNSVPECGIYKLMTEQLAEKTLEDWQSNAEQAVSNVEL 487
            ..|:|::..|         |.||.|||||:.|...:||                  ..|.|::.|
Human   307 NLQNITQGAK---------IPLIVCGDFNAEPTEEVYK------------------HFASSSLNL 344

  Fly   488 AQPFKMASAYG--APEYTHYTTLFAG-C---LDYVFYQNDRFEVLKVVPLPTEEELKANTAIPSA 546
            ...:|:.||.|  .|.||.:....:| |   |||::|......|...:.|.|||::..| .:||.
Human   345 NSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPN-RLPSF 408

  Fly   547 VFPSDHVALVADLKFKSD 564
            .:||||::||.|..|..:
Human   409 NYPSDHLSLVCDFSFTEE 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31759	NP_723735.2	EEP	239..561	CDD:294334	104/337 (31%)
NOCT	NP_036250.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..41
		Deadenylase_nocturnin	144..423	CDD:197330	105/338 (31%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:31147539	219..221		1/1 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:31147539	286..289		2/2 (100%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:31147539	324..326		1/1 (100%)
		Interaction with PPARG. /evidence=ECO:0000250\|UniProtKB:O35710	343..353		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D432310at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850