DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31759 and CNOT6L

DIOPT Version :9

Sequence 1:	NP_723735.2	Gene:	CG31759 / 326158	FlyBaseID:	FBgn0051759	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001374771.1	Gene:	CNOT6L / 246175	HGNCID:	18042	Length:	616	Species:	Homo sapiens

Alignment Length:	461	Identity:	119/461 - (25%)
Similarity:	196/461 - (42%)	Gaps:	116/461 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 VTPEDIG--YHLKFVVTPGNALGMTG-PVVEKITNSAVQESPGRCPFQDRQRHTTN--------- 229
            |.|.::|  :.|:       .||:.| |:.:.|.|  :.:.|      |..|...|
Human   177 VLPYELGRLFQLQ-------TLGLKGNPLSQDILN--LYQDP------DGTRKLLNFMLDNLAVH 226

  Fly   230 ----------SLSESNEI------RVVSYNLLADLYASSDYAGSTLFSYCPAKYLQIDYRKPLFI 278
                      :|.|.::|      .|:.||:|.|.||:..     |:.|||:..|..:|||...:
Human   227 PEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQ-----LYGYCPSWALNWEYRKKGIM 286

  Fly   279 NEIIGYNSDILCLQEVD-QRIFDFDLKEILEQPPYNYHGIMAPKG----------KCAEGVAIFF 332
            .||:..::||:.||||: ::.|...|..:.|:   .|.|..:||.          |..:|.||||
Human   287 EEIVNCDADIISLQEVETEQYFTLFLPALKER---GYDGFFSPKSRAKIMSEQERKHVDGCAIFF 348

  Fly   333 RNSRFDLLDSQILHL---------GSNIPALPVFESLWNKI--KVNAQLAERICERSTTLQTCLL 386
            :..:|.|:....:..         ||        |::.|::  |.|..:|..:..........:.
Human   349 KTEKFTLVQKHTVEFNQVAMANSDGS--------EAMLNRVMTKDNIGVAVVLEVHKELFGAGMK 405

  Fly   387 RIKGTDNYVL-VANTHLYFHPDADHIRLLQMGFSMLFVEQSISKAIKDF--NISSH--------K 440
            .|...|..:| |||.|:::.|:...::|:|   :|:||.:     :|:.  ..||.        .
Human   406 PIHAADKQLLIVANAHMHWDPEYSDVKLIQ---TMMFVSE-----VKNILEKASSRPGSPTADPN 462

  Fly   441 NIGLIFCGDFNSVPECGI------------YKLMTEQLAEKTLEDWQSNAEQAVSNVELAQPFKM 493
            :|.|:.|.|.||:|:.|:            :|...|....:.|.::..|.:...|...:...|::
Human   463 SIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQL 527

  Fly   494 ASAY--GAPEYTHYTTLFAGCLDYVFYQNDRFEVLKVV-PLPTEEELKAN-TAIPSAVFPSDHVA 554
            .|||  ....||:||..|.|.:||:||......||.|: ||..:..::.| |..|....||||.:
Human   528 KSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFS 592

  Fly   555 LVADLK 560
            |:..|:
Human   593 LLTQLE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31759	NP_723735.2	EEP	239..561	CDD:294334	102/371 (27%)
CNOT6L	NP_001374771.1	leucine-rich repeat	99..118	CDD:275378
		LRR	<118..>244	CDD:227223	16/81 (20%)
		leucine-rich repeat	119..141	CDD:275378
		leucine-rich repeat	142..156	CDD:275378
		Deadenylase_CCR4b	252..599	CDD:197339	102/371 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820