DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31759 and Cnot6l

DIOPT Version :9

Sequence 1:	NP_723735.2	Gene:	CG31759 / 326158	FlyBaseID:	FBgn0051759	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_849185.2	Gene:	Cnot6l / 231464	MGIID:	2443154	Length:	555	Species:	Mus musculus

Alignment Length:	463	Identity:	119/463 - (25%)
Similarity:	198/463 - (42%)	Gaps:	115/463 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 YL-VTPEDIG--YHLKFVVTPGNALGMTGPVVEKITNSAVQESPGRCPFQDRQRHTTN------- 229
            || |.|.::|  :.|:       .||:||..:.:...|..|:..|       .|...|
Mouse   113 YLRVLPYELGRLFQLQ-------TLGLTGNPLSQDIMSLYQDPDG-------TRKLLNFMLDNLA 163

  Fly   230 ------------SLSESNEI------RVVSYNLLADLYASSDYAGSTLFSYCPAKYLQIDYRKPL 276
                        :|.|.::|      .|:.||:|.|.||:..     |:.|||:..|..:|||..
Mouse   164 VHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQ-----LYGYCPSWALNWEYRKKG 223

  Fly   277 FINEIIGYNSDILCLQEVD-QRIFDFDLKEILEQPPYNYHGIMAPKG----------KCAEGVAI 330
            .:.||:.:::||:.||||: ::.|...|..:.::   .|.|..:||.          |..:|.||
Mouse   224 IMEEIVNWDADIISLQEVETEQYFTLFLPALKDR---GYDGFFSPKSRAKIMSEQERKHVDGCAI 285

  Fly   331 FFRNSRFDLLDSQILHL---------GSNIPALPVFESLWNKI--KVNAQLAERICERSTTLQTC 384
            ||:..:|.|:....:..         ||        |::.|::  |.|..:|..:........|.
Mouse   286 FFKTEKFTLVQKHTVEFNQVAMANSDGS--------EAMLNRVMTKDNIGVAVVLEVHKELFGTG 342

  Fly   385 LLRIKGTDNYVL-VANTHLYFHPDADHIRLLQMGFSMLFVEQSISKAIKDF--NISSH------- 439
            :..|...|..:| |||.|:::.|:...::|:|   :|:||.:     :|:.  ..||.
Mouse   343 MKPIHAADKQLLIVANAHMHWDPEYSDVKLIQ---TMMFVSE-----VKNILEKASSRPGSPTAD 399

  Fly   440 -KNIGLIFCGDFNSVPECGI------------YKLMTEQLAEKTLEDWQSNAEQAVSNVELAQPF 491
             .:|.|:.|.|.||:|:.|:            :|...|....:.|.::..:.:...|...:...|
Mouse   400 PNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCSGKNGSSEGRITHGF 464

  Fly   492 KMASAY--GAPEYTHYTTLFAGCLDYVFYQNDRFEVLKVV-PLPTEEELKAN-TAIPSAVFPSDH 552
            ::.|||  ....||:||..|.|.:||:||......||.|: ||..:..::.| |..|....||||
Mouse   465 QLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDH 529

  Fly   553 VALVADLK 560
            .:|:..|:
Mouse   530 FSLLTQLE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31759	NP_723735.2	EEP	239..561	CDD:294334	101/371 (27%)
Cnot6l	NP_849185.2	Required for interaction with CNOT1, CNOT3 and CNOT7. /evidence=ECO:0000250	1..152		13/52 (25%)
		leucine-rich repeat	38..57	CDD:275378
		LRR	<57..>183	CDD:227223	17/83 (20%)
		leucine-rich repeat	58..80	CDD:275378
		leucine-rich repeat	81..103	CDD:275378
		leucine-rich repeat	104..126	CDD:275378	5/12 (42%)
		leucine-rich repeat	127..138	CDD:275378	5/17 (29%)
		Nuclease domain. /evidence=ECO:0000250	158..555		104/404 (26%)
		Deadenylase_CCR4b	191..538	CDD:197339	101/371 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724242at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820