DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31759 and Pde12

DIOPT Version :9

Sequence 1:	NP_723735.2	Gene:	CG31759 / 326158	FlyBaseID:	FBgn0051759	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_848783.3	Gene:	Pde12 / 211948	MGIID:	2443226	Length:	608	Species:	Mus musculus

Alignment Length:	599	Identity:	202/599 - (33%)
Similarity:	313/599 - (52%)	Gaps:	61/599 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEKVYLRNASDTKELDIVFRFVNENLKINREFNFRRQMNEPIDAILARIQSNIIGRLAK--SCKK 63
            ||:..:|......:|.:.|...:.:.|     |.:|..:||:...|:||.:|.:...||  :.||
Mouse    34 MERAVVRCVPSEPKLSLSFALADGSHK-----NMQRDQSEPLGRALSRIATNALKGHAKVAAAKK 93

  Fly    64 SKIKPPAEINVKLLSDKYG-------EKFNELTFEDLVVTQDISNVK-------LQVLDTVYDLV 114
            |: |..|..:.....:..|       |...:|.:.:..|.:|:.||.       ||:.|..|.:.
Mouse    94 SR-KNRAHSSGGAACEATGPEPVATCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVE 157

  Fly   115 FNPPWISSLKFLPSCILAGFVIYPTNVQIQFGERQFSKAVWFKAKKPTDTD-------------- 165
            .|||..:.|: ||..|:|||.:.| .:.::||:...|...|:|..||...:
Mouse   158 RNPPTFTELQ-LPRYIMAGFPVCP-KLGVEFGDPASSVFRWYKEVKPGAAEPGDSGPASSSHSSQ 220

  Fly   166 ---WEVCGEGFQYLVTP--EDIGYHLKFVVTPGNALGMTGPVVEKITNSAVQESPGRCPFQDRQR 225
               |...|.. :.:.||  .|||..|:...||||.... ||..|..:...|:..||.|.|..|..
Mouse   221 PSAWIETGVD-ERVYTPCNADIGLRLRLHCTPGNGQRF-GPSRELESLCPVEAGPGTCTFDHRHL 283

  Fly   226 HTTNSLSESNEIRVVSYNLLADLYASSDYAGSTLFSYCPAKYLQIDYRKPLFINEIIGYNSDILC 290
            : |..::|.:.||.||||:|||.||.::::.:.|:.||....|::|||:.|...|:.|||:|::|
Mouse   284 Y-TKKVTEDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLIC 347

  Fly   291 LQEVDQRIFDFDLKEILEQPPYNYHGIMAPKGKCAEGVAIFFRNSRFDLLDSQILHLGSNIPALP 355
            |||||:.:|...|...||  .:...|:.  :.|..||:|.|:|.|:|.||....:.....:.:.|
Mouse   348 LQEVDRAVFSDSLVPALE--AFGLEGVF--RIKQHEGLATFYRKSKFRLLSQHDISFQEALKSDP 408

  Fly   356 VFESLWNKIKVNAQLAERICERSTTLQTCLLRIKGTDN--YVLVANTHLYFHPDADHIRLLQMGF 418
            :.:.|..|:.:|....|::.:||:.||..:|: ..||:  .:.|||||||:||...:|||:||..
Mouse   409 LHKELLEKLALNPLAQEKVLQRSSVLQISVLQ-STTDSSKKICVANTHLYWHPKGGYIRLIQMEV 472

  Fly   419 SMLFVEQSISKAIKDFNISSHKNIGLIFCGDFNSVPECGIYKLMTEQLAEKTLEDWQSNAEQAVS 483
            :::.: :.:|:.:       :..|.:||||||||.|..|:|..:......:..|||.||.|:...
Mouse   473 ALVHI-RHVSRDL-------YPGIPVIFCGDFNSTPSTGMYHFVISGSIAEDHEDWASNGEEERC 529

  Fly   484 NVELAQPFKMASAYGAPEYTHYTTLFAGCLDYVFYQNDRFEVLKVVPLPTEEELKANTAIPSAVF 548
            ::.|:..||:.||.|.|.||:|...|.|||||:|...:..||.:|:|||:.||:..:.|:||...
Mouse   530 SMPLSHCFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNTLEVEQVIPLPSHEEVTTHQALPSVSH 594

  Fly   549 PSDHVALVADLKFK 562
            ||||:|||.|||:|
Mouse   595 PSDHIALVCDLKWK 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31759	NP_723735.2	EEP	239..561	CDD:294334	125/323 (39%)
Pde12	NP_848783.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..111		5/21 (24%)
Pde12	NP_848783.3	EEP	298..607	CDD:294334	124/321 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835686
Domainoid	1	1.000	220	1.000	Domainoid score	I2617
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14272
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56656
OrthoDB	1	1.010	-	-		D432310at33208
OrthoFinder	1	1.000	-	-		FOG0005860
OrthoInspector	1	1.000	-	-		oto95295
orthoMCL	1	0.900	-	-		OOG6_104860
Panther	1	1.100	-	-	LDO	PTHR12121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1970
SonicParanoid	1	1.000	-	-		X4860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800