Protein Alignment CG31759 and PDE12

DIOPT Version :9

• Sequence 1: NP_723735.2
• Gene: CG31759 / 326158
• FlyBaseID: FBgn0051759
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_808881.3
• Gene: PDE12 / 201626
• HGNCID: 25386
• Length: 609
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 201/602 - (33%)
• Similarity: 305/602 - (50%)
• Gaps: 67/602 - (11%)

  Fly     1 MEKVYLRNASDTKELDIVFRFVNENLKINREFNFRRQMNEPIDAILARIQSNIIGRLAK--SCKK 63
            ||:..:|......:|.:.|...:.:.|     |.:|..:||:..:|:||.:|.:...||  :.||
Human    35 MERAVVRCVPSEPKLSLSFALADGSHK-----NMQRDQSEPLGRVLSRIATNALKGHAKAAAAKK 94

  Fly    64 SKIKPPAEINVKLLSDK------YGEKFNELTFEDLVVTQDISNVK-------LQVLDTVYDLVF 115
            |:...|........|..      :.|...:|.:.:..|.:|:.||.       ||:.|..|.:..
Human    95 SRKSRPNASGGAACSGPGPEPAVFCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVER 159

  Fly   116 NPPWISSLKFLPSCILAGFVIYPTNVQIQFGERQFSKAVWFKAKKP------------------- 161
            |||..:.|: ||..|:|||.:.| .:.::||:...|...|:|..||
Human   160 NPPAFTELQ-LPRYIMAGFPVCP-KLSLEFGDPASSLFRWYKEAKPGAAEPEVGVPSSLSPSSPS 222

  Fly   162 ---TDTDWEVCGEGFQYLVTPE--DIGYHLKFVVTPGNALGMTGPVVEKITNSAVQESPGRCPFQ 221
               |:||.|      :.:.||.  |||..||...|||:.... |...|..:...|:..||.|.|.
Human   223 SSWTETDVE------ERVYTPSNADIGLRLKLHCTPGDGQRF-GHSRELESVCVVEAGPGTCTFD 280

  Fly   222 DRQRHTTNSLSESNEIRVVSYNLLADLYASSDYAGSTLFSYCPAKYLQIDYRKPLFINEIIGYNS 286
            .|..: |..::|...||.||||:|||.||.::::.:.|:.||....|::|||:.|...|:.|||:
Human   281 HRHLY-TKKVTEDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNA 344

  Fly   287 DILCLQEVDQRIFDFDLKEILEQPPYNYHGIMAPKGKCAEGVAIFFRNSRFDLLDSQILHLGSNI 351
            |::||||||:.:|...|...||  .:...|:.  :.|..||:|.|:|.|:|.||....:.....:
Human   345 DVICLQEVDRAVFSDSLVPALE--AFGLEGVF--RIKQHEGLATFYRKSKFSLLSQHDISFYEAL 405

  Fly   352 PALPVFESLWNKIKVNAQLAERICERSTTLQTCLLR-IKGTDNYVLVANTHLYFHPDADHIRLLQ 415
            .:.|:.:.|..|:.:.....|::.:||:.||..:|: .|.:...:.|||||||:||...:|||:|
Human   406 ESDPLHKELLEKLVLYPSAQEKVLQRSSVLQVSVLQSTKDSSKRICVANTHLYWHPKGGYIRLIQ 470

  Fly   416 MGFSMLFVEQSISKAIKDFNISSHKNIGLIFCGDFNSVPECGIYKLMTEQLAEKTLEDWQSNAEQ 480
            |..::..        |:..:...:..|.:||||||||.|..|:|..:......:..|||.||.|:
Human   471 MAVALAH--------IRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVINGSIPEDHEDWASNGEE 527

  Fly   481 AVSNVELAQPFKMASAYGAPEYTHYTTLFAGCLDYVFYQNDRFEVLKVVPLPTEEELKANTAIPS 545
            ...|:.|...||:.||.|.|.||:|...|.|||||:|...:..||.:|:|||:.||:..:.|:||
Human   528 ERCNMSLTHFFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQVIPLPSHEEVTTHQALPS 592

  Fly   546 AVFPSDHVALVADLKFK 562
            ...||||:|||.|||:|
Human   593 VSHPSDHIALVCDLKWK 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31759	NP_723735.2	EEP	239..561	CDD:294334	124/322 (39%)
PDE12	NP_808881.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..111		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..230		2/23 (9%)
		EEP	299..608	CDD:294334	123/320 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145620
Domainoid	1	1.000	222	1.000	Domainoid score	I2611
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14272
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2697
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56656
OrthoDB	1	1.010	-	-		D432310at33208
OrthoFinder	1	1.000	-	-		FOG0005860
OrthoInspector	1	1.000	-	-		oto91713
orthoMCL	1	0.900	-	-		OOG6_104860
Panther	1	1.100	-	-	LDO	PTHR12121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1970
SonicParanoid	1	1.000	-	-		X4860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800