DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31759 and Noct

DIOPT Version :9

Sequence 1:	NP_723735.2	Gene:	CG31759 / 326158	FlyBaseID:	FBgn0051759	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_033964.1	Gene:	Noct / 12457	MGIID:	109382	Length:	429	Species:	Mus musculus

Alignment Length:	353	Identity:	108/353 - (30%)
Similarity:	154/353 - (43%)	Gaps:	76/353 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 TNSLSESNEIRVVSYNLLADLYASSDYAGSTLFSYCPAKYLQIDYRKPLFINEIIGYNSDILCLQ 292
            |:..|..:.|||:.:|:||.....    |...|..||.:.|:.:.||.|.:.||:.|..||||||
Mouse   132 TDCSSSHSPIRVMQWNILAQALGE----GKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQ 192

  Fly   293 EVDQRIFDFDLKEILEQPPYNYHGIMAPK--GKC--------AEGVAIFFRNSRFDLLDSQILHL 347
            ||| ..|| ..:.:|.:  ..|.|...||  ..|        .:|.|:||..:||.|:.|
Mouse   193 EVD-HYFD-TFQPLLSR--LGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLISS----- 248

  Fly   348 GSNIPALPVFESLWNKIKVNAQLAERICERSTTLQTCLLRIKGTDNYVLVANTHLYFHPDADHIR 412
             :|| .|.......|::.: ||..|  |:.|.. |.|            :|.|||......:..|
Mouse   249 -TNI-RLTAMTLKTNQVAI-AQTLE--CKESGR-QFC------------IAVTHLKARTGWERFR 295

  Fly   413 LLQMGFSMLFVEQSISKAIKDFNISSHKNIGLIFCGDFNSVPECGIYKLMTEQLAEKTLEDWQSN 477
            ..| |..:|...|:|::..|         |.||.|||||:.|...:||
Mouse   296 SAQ-GCDLLQNLQNITQGAK---------IPLIVCGDFNAEPTEEVYK----------------- 333

  Fly   478 AEQAVSNVELAQPFKMASAYG--APEYTHYTTLFAG-C---LDYVFYQNDRFEVLKVVPLPTEEE 536
             ..|.|::.|...:|:.|..|  .|.||.:....:| |   |||::|......|...:.|.|||:
Mouse   334 -HFASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQ 397

  Fly   537 LKANTAIPSAVFPSDHVALVADLKFKSD 564
            :..| .:||..:||||::||.|..|..:
Mouse   398 IGPN-RLPSFHYPSDHLSLVCDFSFNEE 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31759	NP_723735.2	EEP	239..561	CDD:294334	103/337 (31%)
Noct	NP_033964.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..68
		Deadenylase_nocturnin	142..421	CDD:197330	104/338 (31%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	217..219		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	284..287		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UK39	322..324		1/1 (100%)
		Interaction with PPARG. /evidence=ECO:0000269\|PubMed:20498072	341..351		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840