Protein Alignment mon2 and GEA2

DIOPT Version :9

• Sequence 1: NP_001033884.2
• Gene: mon2 / 326157
• FlyBaseID: FBgn0031985
• Length: 1684
• Species: Drosophila melanogaster
• Sequence 2: NP_010892.1
• Gene: GEA2 / 856691
• SGDID: S000000748
• Length: 1459
• Species: Saccharomyces cerevisiae
• Alignment Length: 1688
• Identity: 293/1688 - (17%)
• Similarity: 520/1688 - (30%)
• Gaps: 672/1688 - (39%)

  Fly    68 ILYPLVQGCETKDLK--IIKFCLGMMQRLITQQVVDQKGALYI------TNALWTLMENNIEEVK 124
            ||.|.:....|..:.  |....|..:|:..|..::::....||      .|||........:::.
Yeast    97 ILQPFLLIVSTSSISGYITSLALDSLQKFFTLNIINESSQNYIGAHRATVNALTHCRFEGSQQLS 161

  Fly   125 ----VLQTVTLLLTTNTVVHGDTLAKAL-------VLCFRLHYAKNPTIVNTAGATIRQLVSLVF 178
                :|:.|.||.:.....:||.|:.::       :|....:..::..:.|.|.:|:..:...:|
Yeast   162 DDSVLLKVVFLLRSIVDSPYGDLLSNSIIYDVLQTILSLACNNRRSEVLRNAAQSTMIAVTVKIF 226

  Fly   179 ER-----------VY----------LEKDSVSSLQQQQSSGSP--------------AEGEG--- 205
            .:           :|          |:.|::.:..:.:..||.              :|.:|
Yeast   227 SKLKTIEPVNVNQIYINDESYTNDVLKADTIGTNVESKEEGSQEDPIGMKVNNEEAISEDDGIEE 291

  Fly   206 -----------------------GNQDVQTFASDAF---LLFQDLVQLVNADQPYWLLGMTEMTR 244
                                   .|..:|.:|.|.:   ::.|.|..|::...|...|..:..||
Yeast   292 EHIHSEKSTNGAEQLDIVQKTTRSNSRIQAYADDNYGLPVVRQYLNLLLSLIAPENELKHSYSTR 356

  Fly   245 TFGLELLEAVLTNFSAVFHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPY 309
            .|||||::..|        |.:..||.|..|:..|:                   :.|:.....:
Yeast   357 IFGLELIQTAL--------EISGDRLQLYPRLFTLI-------------------SDPIFKSILF 394

  Fly   310 FPISMRLLRLVAILIQKYHTILV-------TECEIFLSLIIKFL------------DPDKPAWQR 355
            ...:...|.|:...:|.:.|::|       .:.|:.|:.|...|            :.:||:..:
Yeast   395 IIQNTTKLSLLQATLQLFTTLVVILGNNLQLQIELTLTRIFSILLDDGTANNSSSENKNKPSIIK 459

  Fly   356 ALALEVIHKLVTRSSLIAFFCKSYDLKNHATNIVHDMIAAMGSYIRY--SLINASAMLNGQQNGV 418
            .|.:|.|..|.|||.  :||                    ..::|.:  :|..|...:|
Yeast   460 ELLIEQISILWTRSP--SFF--------------------TSTFINFDCNLDRADVSIN------ 496

  Fly   419 ANSLTAMSGSNQCGFMFRGAYLPLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDM 483
                                                :|:.|.|:   .:|:|
Yeast   497 ------------------------------------FLKALTKL---ALPES------------- 509

  Fly   484 TRSIGGVIQRTPELHPSHNTAVITEEEHKPLCLQLVNSSWSALLSAFIPLVETSIDEATTENILK 548
                                |:.|.|...|:||:           ..:.||:...|.      :|
Yeast   510 --------------------ALTTTESVPPICLE-----------GLVSLVDDMFDH------MK 537

  Fly   549 AM--QNYAALCGMLEQLQPRD---AFIMAMCRASF--PPHYAMSIFANTTQSDGDLRCHTRSGSQ 606
            .:  :.:......:|.|:.||   .||  .|..:|  .|...:.:.
Yeast   538 DIDREEFGRQKNEMEILKKRDRKTEFI--ECTNAFNEKPKKGIPML------------------- 581

  Fly   607 DLSSQFINSCSG-DAGDFRPQIVAVGTPLPSASLPHSVMQAPVMLTNKNLQCMRAI-LFLAHNNG 669
             :...||.|.|. |..:|                         :..|.|....:.| |.|.|.:.
Yeast   582 -IEKGFIASDSDKDIAEF-------------------------LFNNNNRMNKKTIGLLLCHPDK 620

  Fly   670 GILGTSWHIVLQTLQHLVWILGLKPSTGGSLQAMPKPAVEANVGIQTAVMADLPVLSQMLSQLFE 734
            ..|       |.....|....||:              |:..:.|...... ||..||.:.::.|
Yeast   621 VSL-------LNEYIRLFDFSGLR--------------VDEAIRILLTKFR-LPGESQQIERIIE 663

  Fly   735 --SSQYLDDVALHHLIDALCKLSHEAMELAYANREP---SLFAVAK---LLETGLVNMPRIK--V 789
              ||.|.::.....     .|:|..| |...:..:|   |:|.::.   :|.|.|.| |::|  :
Yeast   664 AFSSAYCENQDYDP-----SKISDNA-EDDISTVQPDADSVFILSYSIIMLNTDLHN-PQVKEHM 721

  Fly   790 LWRPLTNHLLEVCQHR------------HIRMRE------------WGVEAITYLVKSALQFKHK 830
            .:...:.:|...|.|:            .||.:|            |..:|...|:.|....
Yeast   722 SFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIVMPEEHHGNEKWFEDAWNNLISSTTVI--- 783

  Fly   831 TPLKENMELQTMLLSPL---------------SELSTVL---------HADVRQ-------RQLD 864
            |.:|::.:.....|:||               |.:||:.         |...|.       ..:.
Yeast   784 TEIKKDTQSVMDKLTPLELLNFDRAIFKQVGPSIVSTLFNIYVVASDDHISTRMITSLDKCSYIS 848

  Fly   865 CVLQILNTAGEILSFGWPAIIEIIGAVNEHHGEPLIRTAFQ-----CLQLVITDFLTVMPWRCLP 924
            ......:...:||:    :|.:....:|..|.:.|...||:     .:|:...|..|.:|
Yeast   849 AFFDFKDLFNDILN----SIAKGTTLINSSHDDELSTLAFEYGPMPLVQIKFEDTNTEIP----- 904

  Fly   925 LCIST-AAKFG-SQTQELNISLTAIGLMWNISDFF---NQNQD-KLMSTQL------------QD 971
              :|| |.:|| |...:||   |.:        ||   .:|:| |:.|.:|            :|
Yeast   905 --VSTDAVRFGRSFKGQLN---TVV--------FFRIIRRNKDPKIFSKELWLNIVNIILTLYED 956

  Fly   972 VSILPD-FPGTVKMPQFDKLWMCLYAKLGELCVDLRP----AVRKS-AGQTLFSTISAHGSLLNP 1030
            :.:.|| ||...|.           .||..|   .:|    ::.|| ..:.|.||.:::......
Yeast   957 LILSPDIFPDLQKR-----------LKLSNL---PKPSPEISINKSKESKGLLSTFASYLKGDEE 1007

  Fly  1031 PTWQAL--------------VWQVLFP-----LLDNVRALSSSASNEK-VDAS------------ 1063
            ||.:.:              :...:|.     ..|.::.|..||..|| .|.|
Yeast  1008 PTEEEIKSSKKAMECIKSSNIAASVFGNESNITADLIKTLLDSAKTEKNADNSRYFEAELLFIIE 1072

  Fly  1064 ---------------GNILIHHSRNTAQK--QWAETQVLTLSGVCRVFNTKRELLQMLGDFERAW 1111
                           |..::       ||  |.:.|:.||...|.|:...|..|:.:..|.....
Yeast  1073 LTIALFLFCKEEKELGKFIL-------QKVFQLSHTKGLTKRTVRRMLTYKILLISLCADQTEYL 1130

  Fly  1112 SLILE---------FIQNAALSKNGEVSLAALKSLQEIMYHN----TAERTERALKDPQTAQEQD 1163
            |.::.         |.|....:..|:..|..|.||.|..::.    ..|...:.|:.....:||.
Yeast  1131 SKLINDELLKKGDIFTQKFFATNQGKEFLKRLFSLTESEFYRGFLLGNENFWKFLRKVTAMKEQS 1195

  Fly  1164 EEIWTIAWNIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDFYIPSQAFLTAL-----IQIFPA 1223
            |.|:            |....|..|.:.:               :.::.|:..|     |....|
Yeast  1196 ESIF------------EYLNESIKTDSNI---------------LTNENFMWVLGLLDEISSMGA 1233

  Fly  1224 IFQHIQVKF-----TAADFDKFCTVLTNAVCIPVQTDAVPY---IMSTVSDTLLTP--LHDG--- 1275
            :..|.::::     :....||                ..||   |..::....||.  |.|.
Yeast  1234 VGNHWEIEYKKLTESGHKIDK----------------ENPYKKSIELSLKSIQLTSHLLEDNNDL 1282

  Fly  1276 ----ILDCMELIQKEATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEHKYAKSSGHYANN 1336
                |...::.:..:...|...||:.......|.|| :|.. .|....:|||
Yeast  1283 RKNEIFAIIQALAHQCINPCKQISEFAVVTLEQTLI-NKIE-IPTNEMESVE------------- 1332

  Fly  1337 ASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQEQILHDIVKALRTPLAMKYKCLSSSTWKL 1401
               |::....:|.          |..:...||.                              |:
Yeast  1333 ---ELIEGGLLPL----------LNSSETQEDQ------------------------------KI 1354

  Fly  1402 AISSLISV-----LHTGLKVARAKPQHFASLWDDLADTLDKFLFPASVCTIEDRGLEEIVLDE 1459
            .|||::::     ||. ||:.:...:.|..    :....:||:..:.:    ::.|::::||:
Yeast  1355 LISSILTIISNVYLHY-LKLGKTSNETFLK----ILSIFNKFVEDSDI----EKKLQQLILDK 1408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	26/155 (17%)
		Sec7_N	213..380	CDD:289549	42/188 (22%)
		DUF1981	827..909	CDD:286414	18/117 (15%)
		Mon2_C	912..1665	CDD:292823	120/661 (18%)
GEA2	NP_010892.1	COG5307	298..1331	CDD:227623	239/1343 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930