DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mon2 and MON2

DIOPT Version :9

Sequence 1:	NP_001033884.2	Gene:	mon2 / 326157	FlyBaseID:	FBgn0031985	Length:	1684	Species:	Drosophila melanogaster
Sequence 2:	NP_014102.1	Gene:	MON2 / 855420	SGDID:	S000005241	Length:	1636	Species:	Saccharomyces cerevisiae

Alignment Length:	1852	Identity:	389/1852 - (21%)
Similarity:	696/1852 - (37%)	Gaps:	455/1852 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GGQDVHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSSQQNSVYYTVNQILYPLVQ 74
            ||.|  .....|:|:.::||.|:|::...|:.|.:::|..|....|.::...:   .....|.|.
Yeast     6 GGFD--SMQRQLEAELRSLSSESKRRNSTIRHASDKSIEILKRVHSFEELERH---PDFALPFVL 65

  Fly    75 GCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIE-EVKVLQTVTLLLTT-NT 137
            .|::::.|:....:..:|.|.|...:.:.....|.:|........:| ::||||.|.:...| ..
Yeast    66 ACQSRNAKMTTLAMQCLQGLSTVPSIPRSRLSEILDAFIEATHLAMEIQLKVLQVVPIFFKTYGK 130

  Fly   138 VVHGDTLAKALVLCFRLHYAKN--PTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQQQQSSGSP 200
            .::|....|.|:.|..|.:..|  |.:|.||.||::||:..:|:|:.:|  ||...:|.:...|.
Yeast   131 FIYGPLCKKLLLCCSNLLHVPNKAPVVVGTASATLQQLIDEIFDRLSIE--SVVDDKQYEVLISN 193

  Fly   201 AEGEGGNQDVQTFASDAFLLFQDLVQL--------VNADQPYWLLGMTEMTRTFGLELLEAVLTN 257
            :|    :..|..:..||..||.::..|        |:.::  .||.:.::...:|||:||::|.|
Yeast   194 SE----SIKVNVYRYDANKLFDNICSLNEISSNGAVSDEE--MLLDIGDIPIDYGLEILESILKN 252

  Fly   258 FSAVFHESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPYFPISMRLLRLVAI 322
            ......|..|.:.||:.:...|:::..|.: :|                   |..::|..|.:.:
Yeast   253 SQKNLLECQDLQYLLRVKAIPLLLRCISSS-RH-------------------FSTAVRSCRCLKL 297

  Fly   323 LIQK-YHTILVTECEIFLSLIIK--FLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDL--- 381
            ||:| |.:||..|.|:.|||:|.  .::.:...|||.|:||:...|.....::......||.
Yeast   298 LIRKEYLSILELELEVILSLLIHGISVESNLSGWQRVLSLELFKDLSQDPEIVNTLYMDYDNYPD 362

  Fly   382 KNHATNIVHDMIAAMGSYIRYSLINASAMLNGQQNGVANSLTAMSGSNQCGFMFRGAYLPLVATY 446
            |.|.              .:|.|.....:||..:     .:|.::.|.....|..    ||:.|.
Yeast   363 KKHV--------------FKYLLKECIVLLNSPE-----YITFLAPSKVVEKMDS----PLITTE 404

  Fly   447 APGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSIGGVIQRTPELHPSHNTAVITEEEH 511
            ...| |..::.:|||.:|.:|..:|.||:   ||........|:.:...|..|........|.|.
Yeast   405 NSTV-KTKFMHLLDKSNAPSINITYIISL---ILTICNHLCEGLNKSALESSPLEKKIEDKEREE 465

  Fly   512 KPLCLQLVNSSWSALLSAFIP-----LVETSIDEATTENILKAMQNYAALCGMLEQLQPRDAFIM 571
            .......|...:|.|.|....     |..||::.:....:::|.|..|...|:| .|:.:    :
Yeast   466 GTGNDSTVVKVYSGLFSGLFELNKLFLYSTSLETSIFHLVVRAFQKLAHSAGVL-SLKDK----L 525

  Fly   572 AMCRASFPPHYAMSIFANTTQSDGDLRCHTRSGSQDLSSQFINSCSGDAGDFRPQIVAVGTPLPS 636
            ..|...|    ::.|..|.|.|:   :......|:...:|...:.|..:....|   ...|..||
Yeast   526 RACMKLF----SILITNNVTSSN---QYSFNDTSKSAKNQHTRNISTSSVTTSP---VESTKNPS 580

  Fly   637 ASLPHSVMQA-------PVMLTNKNLQCMRAILFLAHNNGGILGT-SWHIVLQTLQHLV-WILGL 692
            .|:..|....       |..::::.:..:||::.|:.:.|.|..: ||.....|.|.:. :|.|.
Yeast   581 RSIADSAQNKEMKRRLHPRNISSRQVSLLRALISLSISLGPIFDSESWRYTFLTWQWITYYIYGP 645

  Fly   693 KPSTGGSL--QAMPKPAVEANVGIQTAVMADLPVLSQMLSQLFESSQYLDDVALHHLIDALCKLS 755
            ......|.  :.:|.|.:        ...:|:..:...|::.|||:........|.::..|...|
Yeast   646 SADFKESFYSEDIPPPPI--------LTKSDVTSIESSLTKFFESTSSYSCSTFHLVLTRLILDS 702

  Fly   756 HEAMELAYANRE-----------------PSL----FAVAKLLETGLVNMPRI------KVLWRP 793
            ...:.|...|..                 |.:    |.|.|:.|....|..:.      |.||..
Yeast   703 KNTLTLEQTNLNLNNDIGYHPLDAKDEIIPCIYNKAFFVNKIGELATYNCKKFLFGKNGKELWSL 767

  Fly   794 LTNHLLEVCQHRHI---RMREWGVEAITYLVKSAL-----QFKHKTPLKENMELQTMLL-SPLSE 849
            ::.:::::..:|.:   .:|.:.|...|.::|.|.     ..:....:|:...|:.::: |.::.
Yeast   768 ISTYMIKLISNREMDNDSLRLYTVRVFTDIIKKATNEVGNSDEQDNKVKQFGTLENLVIDSLMAT 832

  Fly   850 LSTVLHADVRQRQL---------DCVLQ-------ILNTAGEILSFGWPAIIEII---------- 888
            ::::...|:.::::         |.:.|       |||..||:|...|..|..||
Yeast   833 INSIKQLDIGKQEIYNGTINVESDILFQLLLTLKEILNEFGELLMNSWTNIFNIINSPFEWTVED 897

  Fly   889 ----------------GAVNEHHGEPLIRTAFQCLQLVITDFLTVMPWRCLPLCISTAAKFGSQT 937
                            |.|.:|  :.:|:.::...:|:..|||..:|...:...|.|...|.||.
Yeast   898 TDFSVNEDIDDSSLFEGIVQKH--KNMIQVSYDVFKLISDDFLQSLPMSVIKFVIDTLVNFVSQK 960

  Fly   938 QELNISLTAIGLMWNISDF----FNQ-----------------NQDKLM----STQLQDVSILPD 977
            :.||||.::|...|.:.|:    ||.                 |..||:    |:...|..:
Yeast   961 RNLNISFSSISQFWLVGDYLRVRFNPETLNLSDEKRRSLSEKINNQKLIEIITSSSSHDWEL--- 1022

  Fly   978 FPGTVKMPQFDKLWMCLYAKLGELCVDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVLF 1042
                     ::.||:.|...|.....|.|..|:..|.||.|..|.:| |:..|| |..:..:|:.
Yeast  1023 ---------YNGLWIYLLKNLINCTNDDRVEVKNGAVQTFFRIIDSH-SVCFPP-WDLIFLEVIE 1076

  Fly  1043 PLLDNVRALSSSASNEKVDASGNILIHHSRNTAQKQWAETQV--------LTLSGVCRVFNTKRE 1099
            |||                              .|:|:..::        :||.|:.:::.
Yeast  1077 PLL------------------------------TKEWSTEELENETDFINVTLQGLIKLYP---- 1107

  Fly  1100 LLQMLGDFE------RAWSLILEFIQNAALSKNGEVSLAALKSLQEIMYHNTAERTERALKDPQT 1158
              :...||:      :.||::|:|::....|.:.....|.:.:.|.:            ||:..|
Yeast  1108 --EHFKDFKNNTTCAKEWSMLLDFLKRLLSSTSNNTKNAVILNYQTL------------LKEIIT 1158

  Fly  1159 AQEQDEEIWTIAWNIWLSIGMESTKMSTSTSAKLQQQNSNGAETQEDFYIPSQAFLTALIQIFPA 1223
            .::...:|......|:....:..:.:||:.|:|          |:.|       .:..||..||.
Yeast  1159 IEDVPSDILKKCCEIFTDYNITYSDLSTNASSK----------TEYD-------CIYELITGFPP 1206

  Fly  1224 IFQHIQVKFTAA--DF-DKFCTVLTNAVCIPVQTDAVPYIMSTVSDTLLTPLHDGILDCMELIQK 1285
            ::|.|. |:.|.  :| :|...:..:|:..|:..:.|.      ..|..:.:...||..:::...
Yeast  1207 LYQLIS-KYDAMTDEFVEKVLLLFNSAIKYPLLPEFVQ------DKTKPSSMQKAILSGLDIFMT 1264

  Fly  1286 EATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEHKYAKSSGHYANNASVEVVSMNYIP-F 1349
            ..:| |:.|..|:......:|.|            ....|..|..|     ..:...|:|.:| |
Yeast  1265 NDSK-DTEILILLQLSTISILAF------------DTREKITKKLG-----PKLPKASLNRLPTF 1311

  Fly  1350 GEKSISICVKLYQTTATED----SVVQEQILHDIVKALRTPLAMKYKCLSSST-----WKLAISS 1405
            ...|...|..|....|..|    |.::.:.:..|:|.|...:..|.....|.:     |.||.:.
Yeast  1312 EAISYMSCSNLRNRIAKIDQFGISTLKAKHILRILKNLAEIIKRKSLITGSESDEIPIWVLASNC 1376

  Fly  1406 LISVLHTGLKVARAKPQHFASLWDD----LADTLDKFLFPASVCTIEDRGLEEIVLDETIDCQVI 1466
            ...:.:   |:       |.||.:|    |.|..........|.|::....|...|.|..|....
Yeast  1377 FCDLSN---KI-------FKSLQEDAENPLKDNFCDLFINVIVVTLQRINPELDNLTEIDDLNEY 1431

  Fly  1467 ELLRDEVLPHSHEMPHQFIMQIVVLLNKGS----IHSASDTNICYESD----------------- 1510
            ...|:.:|.:          :|:.|.|:..    |::..|.:..||.|
Yeast  1432 SKYREILLEN----------RIIDLFNERQLDTFIYAVWDCSFLYEFDELENALMQDCGTFSELS 1486

  Fly  1511 WKLRE-----IFAKT--------------CFETLLQFSLLEDHANTNN--NRLNANVLTAGAAGA 1554
            .||..     ||..|              |.:.|:.|.|     |||.  .:|.|..|:|
Yeast  1487 QKLSSFDFSCIFGSTTNPRFQTKYKCSLECLQDLVNFML-----NTNEKLRKLTAPYLSA----- 1541

  Fly  1555 GGKDFAGRLAVTALLHRFQEVLKRFNDDERQSGKCPLPRFRLSEISFVLKAIATLVVSMKKAPAS 1619
                   |:|:         .|:|:..||...|:.|:|:.|.:|::.:|..:..::..:....::
Yeast  1542 -------RIAL---------ALRRYISDEYLIGRAPIPKLRKTELATLLNGLCVILRGVLDQNST 1590

  Fly  1620 KVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSL 1651
            ..||.     ||     |:...|.||.:.|::
Yeast  1591 LGNKQ-----IG-----VENLQTLSPLILRTI 1612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	44/174 (25%)
		Sec7_N	213..380	CDD:289549	44/177 (25%)
		DUF1981	827..909	CDD:286414	20/124 (16%)
		Mon2_C	912..1665	CDD:292823	172/838 (21%)
MON2	NP_014102.1	DCB	8..176	CDD:406594	43/172 (25%)
		Sec7_N	202..362	CDD:403860	46/181 (25%)
		Mon2_C	936..>1161	CDD:374431	61/286 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344279
Domainoid	1	1.000	61	1.000	Domainoid score	I2550
eggNOG	1	0.900	-	-		E1_KOG1848
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1036
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55736
OrthoFinder	1	1.000	-	-		FOG0004981
OrthoInspector	1	1.000	-	-		oto100199
orthoMCL	1	0.900	-	-		OOG6_102916
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R733
SonicParanoid	1	1.000	-	-		X3515
TreeFam	0	0.000	Not matched by this tool.
	12	11.730