DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mon2 and Mon2

DIOPT Version :9

Sequence 1:	NP_001033884.2	Gene:	mon2 / 326157	FlyBaseID:	FBgn0031985	Length:	1684	Species:	Drosophila melanogaster
Sequence 2:	XP_011241835.1	Gene:	Mon2 / 67074	MGIID:	1914324	Length:	1716	Species:	Mus musculus

Alignment Length:	1786	Identity:	831/1786 - (46%)
Similarity:	1121/1786 - (62%)	Gaps:	218/1786 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VHKFVEALQADFKTLSLETKKKYPQIKEACEEAISKLCTAGSS--------QQNSVYYTVNQILY 70
            |.|.:|.:|:|.:.||||.|||:|.:|||.|..|.|:.|..:.        ::||     ::::.
Mouse    10 VKKLLENMQSDLRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENS-----SEVVQ 69

  Fly    71 PLVQGCETKDLKIIKFCLGMMQRLITQQVVDQKGALYITNALWTLMENNIEEVKVLQTVTLLLTT 135
            |.:.||.||:.||.:.||..:|||::.:||.:..|..|.|.||.||||::||:|:||||.:||||
Mouse    70 PFLMGCGTKEPKITQLCLAAIQRLMSHEVVSETAAGNIINMLWQLMENSLEELKLLQTVLVLLTT 134

  Fly   136 NTVVHGDTLAKALVLCFRLHYAKNPTIVNTAGATIRQLVSLVFERVYLEKDSVSSLQQQQSSGSP 200
            |||||.:.|:||:|||||||:.|:....|||.||:||:|::||||:..|.|....::..    .|
Mouse   135 NTVVHDEALSKAIVLCFRLHFTKDNITNNTAAATVRQVVTVVFERMVAEDDRHRDIEPP----VP 195

  Fly   201 AEGEGGNQDVQTF---ASDAFLLFQDLVQLVNADQPYWLLGMTEMTRTFGLELLEAVLTNFSAVF 262
            .:|....:.|.|.   |.||::|||||.||||||.||||:|||||||||||||||:||.:|..||
Mouse   196 IQGNSNRRSVSTLRPCAKDAYMLFQDLCQLVNADAPYWLVGMTEMTRTFGLELLESVLNDFPQVF 260

  Fly   263 HESNDFRLLLKERVCALVIKLFSPNVKHRQLPAPSNGNAPVPAEKPYFPISMRLLRLVAILIQKY 327
            .:..:|..|||||||.|||||||||:|.||  ..|..::|.|.|||||||.|||||:|::||:::
Mouse   261 LQHQEFSFLLKERVCPLVIKLFSPNIKFRQ--GSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQF 323

  Fly   328 HTILVTECEIFLSLIIKFLDPDKPAWQRALALEVIHKLVTRSSLIAFFCKSYDLKNHATNIVHDM 392
            :::|||||||||||::||||.|||.|.||:|:|.||:|..:..|:..||:|||:|.|:|.:..|:
Mouse   324 YSLLVTECEIFLSLLVKFLDSDKPQWLRAVAVESIHRLCVQPQLLRSFCQSYDMKQHSTKVFRDI 388

  Fly   393 IAAMGSYIRYSLI--------------------NASAMLNGQQNGVANSLTAMSGSNQCGFMFRG 437
            :.|:||:|:...:                    .|||..|....||...:|.:.     .|.:||
Mouse   389 VNALGSFIQSLFLVPPTGNPATANQAGNNNAGGPASAPANSGVVGVGGGVTLLP-----AFEYRG 448

  Fly   438 AYLPLVATYAPGVSKAVYLEMLDKIDASNIPDSYGISVGHAILLDMTRSIGGVI----------- 491
            |::|::.....|.:||.|||||||::...||:.|.:||....|||:.|.|..:|
Mouse   449 AWIPILTVTVQGSAKATYLEMLDKVEPPTIPEGYAMSVAFHCLLDLVRGITTMIEGELGEVEAEG 513

  Fly   492 ------------QRTPELHPS----HNTAV---ITEEEHKPLCLQLVNSSWSALLSAFIPLVETS 537
                        :|..|...|    ..|||   :.||        :|::.|..||:|...|::.|
Mouse   514 PSVTEGASSQSSERRDEQAASDPMDQETAVSRAVWEE--------MVSACWCGLLAALSLLLDAS 570

  Fly   538 IDEATTENILKAMQNYAALCGMLEQLQPRDAFIMAMCRASFPPHYAMSIFANTTQSDGDLRCHTR 602
            .|||.|||||||....|||||.|..:..|||||.|:|:.|.|||||:::...||.:....:.::.
Mouse   571 TDEAATENILKAELTMAALCGRLGLVTSRDAFITAICKGSLPPHYALTVLNATTAATLSNKSYSI 635

  Fly   603 SGSQDLSSQFINSCSGDAGDFRPQIVAVGTPLPSASLPHSVMQAPVMLTNKNLQCMRAILFLAHN 667
            .|.   |...|:..|    :...|:||||.||  |..|    |..||||:||:||||.:|.|||.
Mouse   636 QGQ---SVMMISPSS----ESHQQVVAVGQPL--AVQP----QGTVMLTSKNIQCMRTLLNLAHC 687

  Fly   668 NGGILGTSWHIVLQTLQHLVWILGLKPSTGGSLQAMPKPAVEA-NVGIQTAVMADLPVLSQMLSQ 731
            :|.:|||||.:||.||||||||||||||:||:|:  |..|||. :..:.||||.||||:|.:||:
Mouse   688 HGAVLGTSWQLVLATLQHLVWILGLKPSSGGALK--PGRAVEGPSTVLTTAVMTDLPVISNILSR 750

  Fly   732 LFESSQYLDDVALHHLIDALCKLSHEAMELAYA-NREPSLFAVAKLLETGLVNMPRIKVLWRPLT 795
            |||||||||||:|||||:|||.||.|||::||. |:||||||||||||||||||.||::||||||
Mouse   751 LFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPSLFAVAKLLETGLVNMHRIEILWRPLT 815

  Fly   796 NHLLE-VCQHRHIRMREWGVEAITYLVKSALQFKHKTPLKENMELQTMLLSPLSELSTVLHADVR 859
            .|||| ||||.:.||||||.||:|.|:::.|.|.|:.||.:|..||.:||:||.|:|.:.|.|:|
Mouse   816 GHLLEKVCQHPNSRMREWGAEALTSLIRAGLTFSHEPPLPQNQRLQLLLLNPLKEMSNINHPDIR 880

  Fly   860 QRQLDCVLQILNTAGEILSFGWPAIIEIIGAVNEHHGEPLIRTAFQCLQLVITDFLTVMPWRCLP 924
            .:||:||||||.:.|:.|..|||.::.::||:....||.||||||||||||:||||..||..||.
Mouse   881 LKQLECVLQILQSQGDSLGPGWPLVLGVMGAIRNDQGESLIRTAFQCLQLVVTDFLPTMPCSCLQ 945

  Fly   925 LCISTAAKFGSQTQELNISLTAIGLMWNISDFFNQ----------NQDKLMSTQLQDVSI---LP 976
            :.:..|..||...||||||||:|||:|||||:|.|          .::.....|.::..:   .|
Mouse   946 IVVDVAGSFGLHNQELNISLTSIGLLWNISDYFFQRGETIEKELNKEEAAQQKQAEEKGVSLNRP 1010

  Fly   977 DFPGTVKMPQFDKLWMCLYAKLGELCVDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVL 1041
            ..|.    |.||.||:||||||||||||.||||||||||||||||.|||:||...||..::|:||
Mouse  1011 FHPA----PPFDCLWLCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVL 1071

  Fly  1042 FPLLDNVRALSSSASNEKVDA-SGNILIHHSRNTAQKQWAETQVLTLSGVCRVFNTKRELLQMLG 1105
            |.|||.||..|::|..||::: .|||||||||:||:||||||.||||:||.|:|||:|.|||.||
Mouse  1072 FHLLDRVRESSTTADKEKIESGGGNILIHHSRDTAEKQWAETWVLTLAGVARIFNTRRYLLQPLG 1136

  Fly  1106 DFERAWSLILEFIQNAALSKNGEVSLAALKSLQEIMYHNTAERTERALKDPQ------------- 1157
            ||.|||.::|:.||:||||||.|||||||||.|||:...:..|.....:.|.
Mouse  1137 DFSRAWDVLLDHIQSAALSKNNEVSLAALKSFQEILQIVSPVRDSEKPEPPAVSVPVPVLLGNLS 1201

  Fly  1158 ----------------------------TAQEQDEEIWTIAWNIWLSIGMESTKMSTSTSAKLQQ 1194
                                        |.:.:|.::|..|||.|...|.|||:..:|
Mouse  1202 GPGLSRPFVRTDSIGEKLGRCGSETPVVTDELEDLKLWWAAWNTWHRTGSESTEPPSS------- 1259

  Fly  1195 QNSNGAETQEDFYIPSQAFLTALIQIFPAIFQHIQVKFTAADFDKFCTVLTNAVCIPVQTDAVPY 1259
                   ..|..:||||.|||||:|||||::|||:..|:.||..|...:|.:||.:|:.:||.|:
Mouse  1260 -------VDELTFIPSQPFLTALVQIFPALYQHIKAGFSMADLQKLGVILHSAVSVPISSDASPF 1317

  Fly  1260 IMSTVSDTLLTPLHDGILDCMELIQKEATKPDSHISQLIPAIFRQLLIFSKFACAPPTFQQSVEH 1324
            |:.:.::.:||.|.:.:|..::::||.......::..:.||||.|||.|.:|:|.||.:.| :|.
Mouse  1318 ILPSYTEAVLTSLQEAVLTALDVLQKAICVGPENMQIMYPAIFDQLLAFVEFSCKPPQYGQ-LET 1381

  Fly  1325 KYAKSSGHYANN--------ASVEVVSMNYIPFGEKSISICVKLYQTTATEDSVVQEQILHDIVK 1381
            |      |.||.        |..|.|::||:||.|:|:.:.|.|||.||...:||.|::|.:|:|
Mouse  1382 K------HIANAKYNQIQLFAPAEWVALNYVPFAERSLEVVVDLYQKTACHKAVVNEKVLQNIIK 1440

  Fly  1382 ALRTPLAMKYKCLSSSTWKLAISSLISVLHTGLKVARAKPQH-----FASLWDDLADTLDKFLFP 1441
            .||.||::||.|.|.||||||::||:.||..||.|||   ||     |.|:|.:||.||:.|||.
Mouse  1441 TLRVPLSLKYSCPSESTWKLAVASLLKVLSIGLPVAR---QHASSGKFDSMWPELASTLEDFLFT 1502

  Fly  1442 ASVCTIEDRGLEEIVLDETIDCQVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASDTNIC 1506
            .|: ..::..::|...:|:||.:|::|:..|:||:::.:|..|:.|::.:||||||||...:...
Mouse  1503 KSI-PPDNLSIQEFQRNESIDVEVVQLISAEILPYANLIPKAFVGQMMTMLNKGSIHSQPCSFTE 1566

  Fly  1507 YESDWKLREIFAKTCFETLLQFSLLEDHANTNNNRLNANVLTAGAAGAGGKDFAGRLAVTALLHR 1571
            .|.|.:|||.|:|.|||||||||.             :|.:|....|     :..|:|::.||.|
Mouse  1567 AEIDIRLREEFSKMCFETLLQFSF-------------SNKVTTPQEG-----YISRMALSVLLKR 1613

  Fly  1572 FQEVLKRFNDDERQSGKCPLPRFRLSEISFVLKAIATLVVSMKKAPASKVNKPAWDQLIGLYPYL 1636
            .|:||.|:.:|||.||||||||.:::||.|||||::||:.|:||.....|:...|.|:|.|||.|
Mouse  1614 SQDVLHRYIEDERLSGKCPLPRQQVTEIIFVLKAVSTLIDSLKKTQPENVDGNTWSQVIALYPTL 1678

  Fly  1637 VDCTTTTSPEVSRSLREALLQYTDLLQAPRS 1667
            |:|.|.:|.:|..:|:|||..:.|.:|.|.|
Mouse  1679 VECITCSSSDVGSALKEALAPFKDFMQPPAS 1709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	84/177 (47%)
		Sec7_N	213..380	CDD:289549	106/169 (63%)
		DUF1981	827..909	CDD:286414	42/81 (52%)
		Mon2_C	912..1665	CDD:292823	359/820 (44%)
Mon2	XP_011241835.1	DCB	9..180	CDD:374438	83/174 (48%)
		Sec7_N	211..378	CDD:372313	108/168 (64%)
		DUF1981	<871..930	CDD:370432	30/58 (52%)
		Mon2_C	933..1707	CDD:374431	359/820 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845917
Domainoid	1	1.000	633	1.000	Domainoid score	I173
eggNOG	1	0.900	-	-		E1_KOG1848
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44309
Inparanoid	1	1.050	1466	1.000	Inparanoid score	I110
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55736
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004981
OrthoInspector	1	1.000	-	-		oto94938
orthoMCL	1	0.900	-	-		OOG6_102916
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R733
SonicParanoid	1	1.000	-	-		X3515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790