Protein Alignment mon2 and CG5937

DIOPT Version :9

• Sequence 1: NP_001033884.2
• Gene: mon2 / 326157
• FlyBaseID: FBgn0031985
• Length: 1684
• Species: Drosophila melanogaster
• Sequence 2: NP_001096888.2
• Gene: CG5937 / 31537
• FlyBaseID: FBgn0029834
• Length: 2051
• Species: Drosophila melanogaster
• Alignment Length: 2221
• Identity: 397/2221 - (17%)
• Similarity: 635/2221 - (28%)
• Gaps: 926/2221 - (41%)

  Fly    39 IKEACEEAISKLCTAGSSQQNSVYYTVNQILYPLVQGCETKDLKIIKFCLGMMQRLITQQV---- 99
            |:||  |.:.|...||...|.......|::: |::|              .:..||:...|
  Fly   176 IEEA--EEVKKTAPAGLMTQTQASAVYNEVI-PVMQ--------------WLCSRLVEPNVNASP 223

  Fly   100 ---VDQKGALYITNALWTL---MENNIEE---------VKVLQTVTLLLTTNTVVHGDTLAKALV 149
               .:...:||:|..:.||   :..|:..         .|...|:...|.:...::   |.|...
  Fly   224 NKKCENHSSLYLTECILTLSSALPRNVHANPHFTSFLWQKFCPTLAAALGSPGRIN---LDKKFT 285

  Fly   150 LCFRLHYAKNPT-----------------------IVNTAGA--TIRQLVSLVFERVYLEKDSVS 189
            ....||..:|..                       ::..|||  ::|.::..:|.|:.|
  Fly   286 YKDALHMIENEARGFFTGPGLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEALFHRMLL------ 344

  Fly   190 SLQQQQSSGSP---------------------------AEGEGGNQDVQTFASDAFLLFQDLVQL 227
             |...|:...|                           |:|          .||...||:.||..
  Fly   345 -LPAPQNRTEPLRCVREIFKSPERLIDLAVILYVDKNTAQG----------CSDEMALFRLLVDA 398

  Fly   228 VNADQPYWLLG---MTEMTRTFGLELLEAVLTNF----SAVFHESNDFRLLLKERVCALVIKLFS 285
            :. :..|...|   .||.:....:|.:.|:|.:.    |....||     ::.:::..:|
  Fly   399 ME-ECAYGASGGGSATEASLQASVECMVALLDSLQVLCSGELTES-----MISDQIVQVV----- 452

  Fly   286 PNVKH-----------------RQLPAP--------------------------------SNGNA 301
             |.:|                 .:||||                                |||:.
  Fly   453 -NGRHDLLKDADYSGPLTYQSMARLPAPYRDAIVEFRQTVFETSSGSESEGEPQHEQDAASNGSG 516

  Fly   302 PVPA-------------------------EKPYFPISMRLLRLVAILIQKYHTILVTECEIFLSL 341
            ....                         |.|..||.
  Fly   517 DTEGPEDDDPSSSSDETSRVENRWPYSHLEAPVMPIR---------------------------- 553

  Fly   342 IIKFLDPDKPA-----WQRALALEVIHKLVTRSSLI----------AFFCK--SYDLKNHATNIV 389
                .|.|...     :.|||..:::.||:...|.:          :..|:  |.:..:...|:.
  Fly   554 ----TDSDNDRQHARDFARALRQDLVPKLLRLRSCVELDEAMQEFASAVCQENSMNFSDFDYNLT 614

  Fly   390 HDMIAAMGSYIR-YS--LINASAMLNGQQNGVANSLTAMSGSNQCGFMFRGAYLPL----VATYA 447
              .|.|.|.|:. ||  |::...|..|....||.           |...:...:|:    ..|..
  Fly   615 --AINADGIYLAIYSSLLLSLQLMRAGFYEQVAQ-----------GMSHKDILVPMSEQQFVTSV 666

  Fly   448 PGVSKAVYL------EMLDKIDASNI----PDSYGISVG-HAILLDMTRSIGGV--------IQR 493
            ......|||      |:...:...|:    |......:| ...|:||....||:        .||
  Fly   667 QNTGVLVYLSSPWLCELYQSVTVCNVLEAMPRQQLEGMGPRCALVDMLCDAGGLGATQMLSEWQR 731

  Fly   494 TPELHPSHNTAVITEEEH---------KPLCLQLVNSSWSAL---LSAFIPLVETS--------I 538
            ....:..|.     |||.         |.||.:|:...|.::   ||:.:..::||        :
  Fly   732 LQTANVKHK-----EEEQLHDKRREAAKKLCRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVAL 791

  Fly   539 DEATTENILKAMQNYA------ALC--GM-----------LEQLQPRDAFIMA--MCRASFPPHY 582
            .:.|..  :||..|.:      |:|  |:           |:.|..:...::|  :|:.|.|...
  Fly   792 SKRTLR--VKAKANKSNGEALYAMCLDGLHSAATLSNSLNLQHLAGKILNLLASNVCQTSGPRIS 854

  Fly   583 AMSIFANTTQSDGDLR---------------C-HTRSGSQDLSSQFINSCSGDAGDFRPQIVAVG 631
            |....:......|.|.               | |......::.|....:.|...|..|..: ..|
  Fly   855 ASQAMSMDVVLTGGLNLGSYSADCWPSIFAVCRHVSQLEHEIFSMQNPAISASPGSSRRDL-ETG 918

  Fly   632 TPLPS---------ASLP----------HSVMQAPVMLTNKNLQCM------------------- 658
            ..|.:         :|:|          :|.:|||:...|.|:..:
  Fly   919 EKLSNGNAQDKLNLSSIPIDDDETCVDVYSFLQAPMQSPNTNITSILKVYSGTNETVLLSQSDTS 983

  Fly   659 RAILFLAHNNGGILG-----TSWHIVLQTLQHL-------------------VWILGLKPSTG-G 698
            :.:..|:|....:.|     .|...:.|.|:||                   :|    .||.| .
  Fly   984 KVLCALSHQAENLFGDAAERLSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIW----WPSKGWK 1044

  Fly   699 SLQAMPKPAVEANVGIQTAVMADLPVLSQMLSQLFESSQYLDDVALH----------HLIDALC- 752
            .|.::|...:...:|..|.             ::|.||:.|    ||          ||:||.|
  Fly  1045 KLDSLPMSLLLHRIGDVTL-------------KVFRSSRPL----LHVLKVWAITGPHLMDAACH 1092

  Fly   753 ------------------KLSHEAMELAYANREPSLF------------------AVAKLLETGL 781
                              .|..|..||.|.:...:|.                  .||.|.|...
  Fly  1093 RDRMISKRAIEYIHDIITALLVEQSELPYFHFNEALLKPFENLLSMDTDVDVQDQIVACLYEVVE 1157

  Fly   782 VNMPRIKVLWRPLTNHLLEVCQHRHIRMREWGVEAITYLVKSALQFKHKTPLKENMELQTMLLSP 846
            .:...|:..||||...|      |:.|.|...:..|..:.:..|.       .:|
  Fly  1158 AHRTEIRSGWRPLFGTL------RNARSRMLNMSNIIDIFRVFLD-------SDN---------- 1199

  Fly   847 LSELSTVLHADVRQRQLDCVLQILNTAGEILSFGWPAIIEIIGAVNEH-----HGEPLIRTAFQC 906
                 |::.|:.   .|||:|.:|            :.:||.|..|.:     .|.....||...
  Fly  1200 -----TLVFANA---GLDCILCLL------------SYLEISGGGNNNACSGGSGSAAGGTASNG 1244

  Fly   907 LQ------LVITDFL--TVMPWRCLPLCIS---------TAAKFGSQTQELNISLTAI------G 948
            .|      ...||||  |:   |.|..|.|         ....|.|..:...||.|.|      .
  Fly  1245 GQQEEDNTFRPTDFLHETL---RFLERCSSILGFMHSMPKCPNFHSTYKIKGISYTHIIDANIPS 1306

  Fly   949 LMWNISDFFN-----QNQDKLMSTQLQDVSILPDFPGTVKMPQFD------KLWMCLYAKLGELC 1002
            .|.|.:.|.|     :|:..::|.:    |:..|....||:.:.|      |:|..|...|
  Fly  1307 SMENFTYFGNDYLQTRNEQYMISYR----SLHIDKDTIVKIDEMDKPSGVLKVWFLLLDGL---- 1363

  Fly  1003 VDLRPAVRKSAGQTLFSTISAHGSLLNPPTWQALVWQVLFPLLDNVRALSSSASNEKVDASGNIL 1067
                                .:..::.|.:.||.:.|.:|.|..|:.|      :..:| .|...
  Fly  1364 --------------------TNSLIVCPYSHQAPILQTIFKLFKNLLA------SPGID-FGFYC 1401

  Fly  1068 IHHSRNTAQKQWAETQVLTLSGVCRVFNTKRELLQML-GDFER----AWSLILEFIQNAA----- 1122
            |:|......:.|           .|..|......|:: .:|:.    ...|::|||:.:.
  Fly  1402 INHLLVPMIQDW-----------LRYINKTGSSWQLVEKNFKHCCCMTTDLVVEFIEKSVPEQRR 1455

  Fly  1123 LSKNGEVSLAAL-KSLQEIMYHN---TAERTERALKDPQTAQEQDEEIWTIAWNIWLSIGMESTK 1183
            |....:..||.: .....::|..   ..||.||..:..|:...||.           ..|.....
  Fly  1456 LGAGTKTRLAQIVHPADNLLYSKLKFVTERIEREQQQQQSPSVQDH-----------GCGYTQQY 1509

  Fly  1184 MSTSTSAKLQQQNSNG-----------------------------------AETQEDFYIPSQAF 1213
            .|:|:||..:||.:.|                                   |::||.....|.:.
  Fly  1510 DSSSSSASEEQQKNGGGVGGGGSNLIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSC 1574

  Fly  1214 LTALIQIFPAIFQHIQVKFTAADFDKFCTV----------------------------------- 1243
            |..:|.....:|...|.....:...:.|||
  Fly  1575 LKHVILSTGMLFNESQWMIACSAIHRACTVTIAPLRQLSFAFHEKSNSFYGDCANVKVAARRDSS 1639

  Fly  1244 ---------LTNAVCI------PVQTDAVPYIMS--TVSDT-----LLTPLHDGILDCMELIQKE 1286
                     |...|.:      |.|..|.....|  .:||.     ||.||::|.
  Fly  1640 LEELARIYALAQQVFLSDNQREPGQNQAPTPSASQCKLSDDRSYSFLLYPLNNGF---------- 1694

  Fly  1287 ATKPDSHISQLIPAI-FRQL----------------LIFSKFACAPPTFQQSVEHKYAKSSGHYA 1334
                :|::...:..| |:.|                |:.|:..|.|......:...||.|:...:
  Fly  1695 ----NSNLDNFVIRIPFKNLVVGLLANQMLLQLVAKLLLSRLKCVPQAVSTCIFDNYAASAASPS 1755

  Fly  1335 NNASVEVVSMNYIPFGEKSISI-CVKLYQTTATE-DSVVQEQILHDIVKALRTPLAMKYKCLSSS 1397
            ::..::        |..|.|.: |||.|..:|.| ||....:.|...|..:.. .|..||.::||
  Fly  1756 HDYDLD--------FRSKEILLRCVKQYLMSALEFDSRPGLKFLMQKVSNIEY-AANLYKQMTSS 1811

  Fly  1398 TWKLAISSLISVLHTGLKVARAKPQHFASLWDDLADTLDKFLFPASVCTIEDRGLEEIVLDETID 1462
             |.:...:|:                                         |..|.:||
  Fly  1812 -WMIYYIALV-----------------------------------------DSHLNDIV------ 1828

  Fly  1463 CQVIELLRDEVLPHSHEMPHQFIMQIVVLLNKGSIHSASD---TNICYESDWKLREIFAKTCFET 1524
              |..|..:::         .||::....||..::....:   ...|.:..|.|      .| |.
  Fly  1829 --VYNLGPEDL---------NFILESCSRLNTTTVKKKENFVRYLFCLQDAWNL------VC-EL 1875

  Fly  1525 LLQFSLLED-----------------HANTN------NNRLNANVLTAGAAGAGGKDFA------ 1560
            .|..|.|.:                 |..|.      |...:|.:...|:....|...:
  Fly  1876 YLSNSALHEIESGSGKLRQKPPQLLHHPQTKPMCISLNGNGDAEMTDTGSGSGSGSSTSPSKCVQ 1940

  Fly  1561 ----GRLAVTALLHRFQEVLKRFN--DDERQS----GKCPLPRFRLSEISFVLK-------AIAT 1608
                ..:.:|.|:..||... |.|  |..||:    .:...|.......|.:||       |:|.
  Fly  1941 LQEEENVTMTTLISEFQPKC-RSNPFDTNRQAKSSEAESISPEIEQQRASSILKDSNYKRAALAQ 2004

  Fly  1609 LVVSMKKAPASKVNKPAWDQLIGLYPYLVDCTTTTSPEVSRSLREALLQYTDLLQAPRSCSAATS 1673
            |||:                               |.|:.|||.....:...||..|....|.
  Fly  2005 LVVA-------------------------------SMELLRSLPGEAEENLKLLMTPTIREAF-- 2036

  Fly  1674 NDNVIQSNGQE 1684
              .::|..|.|
  Fly  2037 --RLVQLQGNE 2045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mon2	NP_001033884.2	DCB	13..184	CDD:292830	34/188 (18%)
		Sec7_N	213..380	CDD:289549	40/264 (15%)
		DUF1981	827..909	CDD:286414	16/92 (17%)
		Mon2_C	912..1665	CDD:292823	174/954 (18%)
CG5937	NP_001096888.2	Sec7	451..692	CDD:294092	43/291 (15%)
		DUF1981	1115..>1179	CDD:286414	16/69 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030